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Pistoia Alliance USA Conference 2016

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Startup: Pharmacelera

Publié dans : Sciences
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Pistoia Alliance USA Conference 2016

  1. 1. Enric Gibert - PhD, CEO Boston, October 18th 2016 President’s Startup Challenge NEXT GENERATION DRUG DISCOVERY SOLUTIONS
  2. 2. Disruptive Solutions Mandatory to Improve R+D Pharmaceutical R+D Productivity is Lowering High R+D costs Lower patent lifetime Fewer New Molecular Entities (NME) RETURN ON INVESTMENT
  3. 3. We Find Better Molecules Faster Pharmacelera develops software and hardware solutions for drug discovery that... ❶ …find better candidate molecules… More chances to become a drug More chances to be patented +1% SUCCESS RATE +$52M BENEFITS
  4. 4. We Find Better Molecules Faster Pharmacelera develops software and hardware solutions for drug discovery that... ❶ …find better candidate molecules… More chances to become a drug More chances to be patented ❷ …in less time! More time to design better molecules +1% SUCCESS RATE +$52M BENEFITS
  5. 5. PharmDB Fragment and compound data base with pre-computed descriptors We Own Disruptive Technology USERS Computational and medicinal chemists PharmDesign SOFTWARE HARDWARE PharmEngine Molecular algorithms based on full 3D representation of the interaction fields Based on 15+ years of research at CBDD research group (UB) PharmScreen Accurate virtual screening GRAPHICAL USER INTERFACE APPLICATIONS PharmQSAR 3D Quantitative Structure- Activity Relationship (QSAR) tool CORE SOFTWARE TECHNOLOGY PharmaBox Computing platform equipped with hardware accelerators Based on 20+ years of experience on hardware design and programming USABILITY NEW AND BETTER MOLECULAR SKELETONS FASTER RESULTS AND USABILITY CORE HARDWARE TECHNOLOGY
  6. 6. 0 0,2 0,4 0,6 0,8 1 Input 1 Input 2 Traditional platform PharmaBox by Pharmacelera 0,00% 20,00% 40,00% 60,00% 80,00% 100,00% CDK2 HSP90 TK MCH PDE5 Best software from competition PharmEngine by Pharmacelera We Own Disruptive TechnologyACCURACY PharmaBox: THE HARDWARE PLATFORMPharmEngine: THE ALGORITHMS Electrostatic fields Steric fields Hydrophobic Fields OUR SOFTWARE FINDS 4X MORE ACTIVE COMPOUNDS THE 2 PILLARS OF OUR TECHNOLOGY OUR HARDWARE PROVIDES ANSWERS 20 TIMES FASTER TO CUSTOMERS Xeon Phi Graphics Processing Units (GPU) Field-Programmable Gate Arrays (FPGA) TIME Higher is better Lower is better
  7. 7. • We use a flexible customer engagement strategy • Proof-of-concept vs. free demos • Different pricing strategies based on customer segmentation Pharmacelera Uses a Scalable Business Model CLOUD PharmScreen PharmQSAR PharmaBoxHW SW CUSTOMERS Software-as-a-Service Hardware-as-a-Service PharmScreen PharmQSAR SW PharmScreen PharmQSAR PharmaBoxHW SW Hardware/Software usage license Pharma R&D departments Contract Research Organizations (CROs)Biotech Academia € € Software usage license €
  8. 8. High Growth Market with Big Opportunities $1.5B 2020 SCHRÖDINGER 13% CERTARA 18% OTHERS 33% DS BIOVIA (Accelrys) 38% $625M 2016 Compound Annual Growth Rate = +25% Hardware Acceleration No acceleration Little acceleration Full acceleration Pharmacophore One interaction field Precision All interaction fields
  9. 9. Strong Growth Based on Best-in-Class Strategy 2019 20202018201720162015 WORLD-WIDE REFERENCE LIGAND-BASED CADD COMPANY FOUNDATION Revenue 5,000 € 150,000 € 510,000 € 2M € 4.3 M € Employees 6 8 11 17 25 + Presence UK + Presence US (West) + Presence Germany + Presence Switzerland+ Presence US (East) TECHNOLOGY PharmQSAR 1.0 PharmScreen 1.0 PharmQSAR 1.1 PharmScreen 2.0 PharmaBox 1.0 PharmQSAR 1.2 PharmScreen 2.1 PharmDesign 1.0 PharmaBox 1.1 PharmQSAR 1.3 PharmScreen 3.0 PharmDesign 1.1 PharmaBox 2.0 PharmQSAR 1.4 PharmScreen 3.1 PharmDesign 2.0 PharmaBox 2.1 INTERNATIONAL DEPLOYMENT Headquarters and R+D Barcelona
  10. 10. We Are a Strong Multi-Disciplinary Team Enric Gibert - CEO 10 years experience at INTEL Enric Herrero - CTO 3 years experience at INTEL Javier Luque – Scientific Director CBDD research group leader (UB) Manel López – Commercial Advisor Head of Computational Chemistry at AB Science (France) Oscar Farrés – Financial Advisor Investment manager at European Investment Fund (Luxembourg) Business Development Advisor Marketing & Communications Advisor Albert Zamora – Strategy Advisor Founder and CEO at Bionure (United States) Joan Bigorra – Scientific Advisor Director Strategy/Innovation at Barcelona ISGlobal EXECUTIVE TEAM ADVISORY BOARD
  11. 11. Why is Pharmacelera here Today? and ? ? GROW ADVISORY BOARD ❸❶ MISSION ALIGNMENT ❷ COLLABORATIONS PRESIDENT’S STARTUP CHALLENGE and ❶ RECOGNITION ❷ MENTORSHIP = ACCELERATE STRATEGY AND INTERNATIONALIZATION ❸ THOMSON REUTERS = BUSINESS INTELLIGENCE
  12. 12. THANK YOU! info@pharmacelera.com Partnerships and collaborations:

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