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Supply of oxygen to tissues mainly involves two systems i.e. respiratory system and the cardiovascular system. Supply of oxygen to tissues depends upon Adequate PO2 in atmospheric air Adequate pulmonary ventilation Adequate gaseous exchange in the lungs Adequate uptake of oxygen by the blood Adequate blood flow to the tissues Adequate ability of the tissues to utilize oxygen Oxygen diffuses from the alveoli into the pulmonary capillary blood because the oxygen partial pressure (Po2) in the alveoli is greater than the Po2 in the pulmonary capillary blood. In the other tissues of the body, a higher Po2 in the capillary blood than in the tissues causes oxygen to diffuse into the surrounding cells. The Po2 of the gaseous oxygen in the alveolus averages 104 mm Hg, whereas the Po2 of the venous blood entering the pulmonary capillary at its arterial end averages only 40 mm Hg Therefore, the initial pressure difference that causes oxygen to diffuse into the pulmonary capillary is 104 – 40, or 64 mm Hg. About 98 percent of the blood that enters the left atrium from the lungs has just passed through the alveolar capillaries and has become oxygenated up to a Po2 of about 104 mm Hg. Another 2 per cent of the blood which supplies mainly the deep tissues of the lungs and is not exposed to lung air. This blood flow is called “shunt flow,” meaning that blood is shunted past the gas exchange areas One gram of Hb can bind 1.34 ml of Oxygen Normal level of Hb is 15 grams/dL Thus 15 grams of hemoglobin in 100 milliliters of blood can combine with a total of almost exactly 20 milliliters of oxygen if the hemoglobin is 100 per cent saturated This is usually expressed as 20 volumes per cent Hemoglobin is a conjugated protein consisting of heme and globin. The ferrous form can bind oxygen. Hemoglobin molecule consists of four subunits each consists of one heme and one polypeptide chain Each subunit can bind one molecule of Oxygen Oxygenation is a very rapid and reversible process and it can occur in 0.01 seconds When PO2 is high, oxygen binds with Hb to form Oxyhemoglbin When PO2 is low oxygen leaves Hb to form Deoxy Hb. Factors that shift the oxygen hemoglobin dissociation curve
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Gas exchange between the alveoli and the pulmonary capillary blood occurs by diffusion, as will be discussed in the next chapter. Diffusion of oxygen and carbon dioxide occurs passively, according to their concentration differences across the alveolar-capillary barrier. These concentration differences must be maintained by ventilation of the alveoli and perfusion of the pulmonary capillaries. Alveolar ventilation brings oxygen into the lung and removes carbon dioxide from it. Similarly, the mixed venous blood brings carbon dioxide into the lung and takes up alveolar oxygen. The alveolar Image not available. and Image not available. are thus determined by the relationship between alveolar ventilation and pulmonary capillary perfusion. Alterations in the ratio of ventilation to perfusion, called the Image not available., will result in changes in the alveolar Image not available. and Image not available., as well as in gas delivery to or removal from the lung. Alveolar ventilation is normally about 4 to 6 L/min and pulmonary blood flow (which is equal to cardiac output) has a similar range, and so the Image not available. for the whole lung is in the range of 0.8 to 1.2. Image not available. However, ventilation and perfusion must be matched on the alveolar-capillary level, and the Image not available. for the whole lung is really of interest only as an approximation of the situation in all the alveolar-capillary units of the lung. For instance, suppose that all 5 L/min of the cardiac output went to the left lung and all 5 L/min of alveolar ventilation went to the right lung. The whole lung Image not available. would be 1.0, but there would be no gas exchange because there could be no gas diffusion between the ventilated alveoli and the perfused pulmonary capillaries. Oxygen is delivered to the alveolus by alveolar ventilation, is removed from the alveolus as it diffuses into the pulmonary capillary blood, and is carried away by blood flow. Similarly, carbon dioxide is delivered to the alveolus in the mixed venous blood and diffuses into the alveolus in the pulmonary capillary. The carbon dioxide is removed from the alveolus by alveolar ventilation. As will be discussed in Chapter 6, at resting cardiac outputs the diffusion of both oxygen and carbon dioxide is normally limited by pulmonary perfusion. Thus, the alveolar partial pressures of both oxygen and carbon dioxide are determined by the Image not available. If the Image not available. in an alveolar-capillary unit increases, the delivery of oxygen relative to its removal will increase, as will the removal ...
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The presentation which won the Best Paper award at the Students' Paper Presentation in Rhapsody 2010. This paper was presented by Dr. Rimesh Pal Medical College Kolkata, 3rd Professional MBBS Student.
Diabetes Mellitus: Presentation and CLinical Examination
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Difference Between Skeletal Smooth and Cardiac Muscles
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Circulatory Shock, types and stages, compensatory mechanisms
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MedicoseAcademics
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Resp Phys 1
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Respiratory Physiology
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Pulmonary Ventilation Insert
fig. 16.15
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Terms Used to
Describe Lung Volumes and Capacities
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Partial Pressures of
Gases in Inspired Air and Alveolar Air Insert fig. 16.20
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