Pharma AI & IOT presentation 2019

Transforming health &
medicine into a networked
economy
with consumer data at the
centre
A Strategic View
Dr Raminderpal Singh

Dr Raminderpal Singh | raminderpal@anduril.uk | Copyright ©2019 Anduril Ltd 2
An Interview with Kevin Weil and Dante Disparte About Libra and Calibra
https://stratechery.com/2019/an-interview-with-kevin-weil-and-dante-disparte-about-libra-and-calibra/
Networked Economies
can be powerful and
disruptive

Consumer data access and analysis are becoming common
Biopharma, biotechs, hospitals, and research centres are evolving
New ecosystem dynamics & enablers are required
Principles to ecosystem success are critical
Example enablers exist, as drivers for networked economies
MOTIVATION
MEANS
METHOD

Dr Raminderpal Singh | raminderpal@anduril.uk | Copyright ©2019 Anduril Ltd
Each of us
in this room
is both a producer and
a consumer in the pharma
networked economy
4
??

… and we can
produce much
information that
pharma finds
valuable

According to a recent analytical report by Visiongain, drug discovery outsourcing will continue to grow over the
next decade and will rise to a $43.7 billion dollar industry by 2026, as compared to an estimated 19.2 billion in
2016 (or $21.2 billion according to Kalorama Information).
… over 80% of bio-pharma respondents report increased alliance activity compared to five years ago.
Getting ideas and expertise from external sources is a well-established practice in the pharmaceutical industry
with about one-third of all drugs in the pipelines of the top ten pharmaceutical companies initially developed
elsewhere, according to a 2014 WSJ article by Jonathan D. Rockoff.
https://www.biopharmatrend.com/post/30-pharma-rd-outsourcing-is-on-the-rise/
Outsourcing & collaborations in Life Sciences
is already very common

However, {outsourcing + collaboration}
in itself is not sufficient
Networked economies need to be
designed, built and then scaled using
structured methods & system thinking
i.e. {efficiency & effectiveness} in
networks is not created by chance or by
common sense alone
https://www.kbmanage.com/concept/systems-thinking-st

The good news is that
biologists are natural
system (network) thinkers!
https://www.amazon.co.uk/Keystone-Advantage-Ecosystems-Innovation-Sustainability/dp/1591393078

Analyses should be
performed across the
internalised and
externalised network:
● Exchange
● Impact
● Value Creation
https://www.amazon.co.uk/Future-Knowledge-Increasing-Prosperity-Networks/dp/0750675918

Adjacent networks to
pharma also exist
e.g. Healthcare, Social
Services, Wellness ...
10
https://www.amazon.co.uk/Future-Knowledge-Increasing-Prosperity-Networks/dp/0750675918

They all form one big network with the consumer at the centre
...

Principles of
Success:
Productivity
Robustness
Niche Creation
12
https://www.amazon.co.uk/Keystone-Advantage-Ecosystems-Innovation-Sustainability/dp/1591393078
“Productivity. The most important measure of a biological ecosystem’s health is its ability to effectively
convert non biological inputs, such as sunlight and mineral nutrients, into living outputs—populations of
organisms, or biomass. The business equivalent is a network’s ability to consistently transform technology
and other raw materials of innovation into lower costs and new products.
Robustness. To provide durable benefits to the species that depend on it, a biological ecosystem must
persist in the face of environmental changes. Similarly, a business ecosystem should be capable of
surviving disruptions such as unforeseen technological change. The benefits are obvious: A company that
is part of a robust ecosystem enjoys relative predictability, and the relationships among members of the
ecosystem are buffered against external shocks.
Niche Creation. Robustness and productivity do not completely capture the character of a healthy
biological ecosystem. The ecological literature indicates that it is also important these systems exhibit
variety, the ability to support a diversity of species. There is something about the idea of diversity, in
business as well as in biology, that suggests an ability to absorb external shocks and the potential for
productive innovation.”

Physiological,
Environmental, and
Behavioural data
Driving scientific
innovations and
innovative services

Medical data analysis &
sharing
Long term vision
- Starting with value
creation and
expanding to
network effects

In-silico de novo
antibody design
Driving rapid design
and validation of new
drugs
Disrupting the supply
chain
In-Silico design

“OWKIN, a New York City-based company that provides machine learning tools for
medical research purposes, has launched an AI-powered network comprised of 44
hospitals and research institutions in the United States and Europe. Members
include Cleveland Clinic, Mount Sinai and Groupe AP-HP, a group of 39 hospitals in
France.
Dubbed the OWKIN Loop Network, the initiative allows researchers to train
predictive models on real-world data and transfer the gained knowledge to a
collective intelligence. Fellow researchers, partner hospitals and pharmaceutical
companies are then able to use the information to refine patient treatment and
expedite drug R&D.”
“Ten large pharmaceutical companies, including Johnson & Johnson, AstraZeneca
and GSK, are embarking on the first collaboration to train their drug-discovery,
machine-learning algorithms on each other’s data.
Owkin, a Google Ventures-backed start-up based in New York and Paris, has
developed a secure, blockchain-based system that allows an algorithm to trawl
competitors’ data with full traceability — but crucially, without revealing commercial
secrets to rivals.”
Real world data &
AI
https://medcitynews.com/2018/12/owkin-ai-research-network/
https://www.ft.com/content/ef7be832-86d0-11e9-a028-86cea8523dc2

Apple and Alphabet Both Want to Revolutionize Healthcare
But in Different Ways
Unlike the Apple Watch, Verily’s Study Watch is designed specifically
for trials and is given to participants by trial organisers.
https://www.ft.com/content/5a73ad44-474f-11e9-b168-96a37d002cd3
https://www.wearable-technologies.com/2019/04/apple-and-alphabet-both-want-to-revolutionize-healthcare-but-in-different-ways/

https://www.businessinsider.com/alphabet-amazon-apple-and-microsofts-influence-in-healthcare-2018-7?r=US&IR=T

Consumer data access and analysis are becoming common
Biopharma, biotechs, hospitals, and research centres are evolving
New ecosystem dynamics & enablers are required
Principles to ecosystem success are critical
Example enablers exist, as drivers for networked economies

Finally, important to remember that
the consumer should be the ultimate winner ...

Pharma AI & IOT presentation 2019

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