The document provides a summary of the history of diabetes treatment. It describes how treatment typically begins with lifestyle changes like diet and exercise. If those don't control blood sugar levels, oral medications like metformin and sulfonylureas may be prescribed. Over time, additional drugs from different classes like glitazones, sitagliptin, meglitinides, and alpha-glucosidase inhibitors are often added to better control blood sugar. Eventually, many patients transition to taking insulin to manage their diabetes.

1. History of Diabetes<br />History of diabetes whether his-story or her-story, all have the same too familiar script.Once you are entered into the diabetic storybook as the main character, your biography starts with lifestyle changes like reducing weight, having more exercise (workouts), and consciously planned dieting.If mending your ways still keeps you weak after a few weeks, you try to get into form with Metformin or even adding fertilizers (Sulphonyl-ureas). As days go by, you enter the glittering zone with Glitazones or sit-a-while with Sitagliptin. Your post-prandial excursions may be accompanied by Metaglinides or the travel accelerates with addition of more gas (Acarbose or Volibose), literally and physically. Your half-tablet a day becomes full or even two or more with more additions than few deletions, until the final stony tablet threatens to invite your epigraph on it.Don’t lose heart and hang the curtains… your true friend arrives. Enter the INSULIN.<br />