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S A    H
                                                                                      Healthcare
                                                                                      Update
           MAY 15, 2012
 Outlook
Positive   Record 1Q Sales; Nerve Regeneration Gaining                                AxoGen, Inc.
           Traction                                                                   OTCBB                                   AXGN.OB

           Summary and Recommendation                                                 Analysts
           We reiterate our positive outlook on AxoGen, Inc. (AXGN.OB) shares         Price Target*                             $5.25
           given the company’s level of execution and progress demonstrated
                                                                                       Analysts Rating*                                  BUY
           within sales and marketing. The company reported record 1Q12
                                                                                       Current Px                                        $3.79
           revenues of $1.7 million, which was ahead of consensus estimates of
           $1.6 million.                                                               52-Week High                                      $4.00
                                                                                       52-Week Low                                       $1.10
           AxoGen, Inc. is an emerging regenerative medicine company focused           Shares Out. (mm)                                  11.06
           on the commercialization of its portfolio of proprietary products and       Float (mm)                                         4.40
           technologies for peripheral nerve reconstruction and regeneration.          Market Cap (mm)                                   $41.9
                                                                                       Total Debt (mm)                                    $5.0
           The company’s portfolio of regenerative technology for peripheral           Cash (mm)                                          $5.6
           nerve repair provides it an opportunity to participate in a market          EV (mm)                                           $42.5
           estimated to be $1 billion.                                                 FYE                                                Dec

           1Q12 revenue growth demonstrate increased penetration
           AxoGen reported record revenues of $1.7 million, an increase of 47%                                   2011 2012E*         2013E*
           over 1Q11 revenues of $1.1 million and ahead of FirstCall consensus        Revenues (mm)                $4.8       $9.3       $20.4
           estimates of $1.6 million. Increased penetration into the companies
                                                                                      Gross Profit (mm)             $2.4       $6.6       $17.1
           key accounts attributed to higher results.        The company also
                                                                                      Gross Margin                 51%        71%         84%
           continues to expand its sales force, which increased to 16 direct
           representatives and 21 independent sales representatives. From all         EPS                        ($2.8)    ($0.68)     ($0.23)
           indications, it is apparent that AXGN has begun to yield the benefits       *All estimates including price target and rating are
           associated with a maturing sales force that is garnering traction in the   based on FirstCall analyst consensus.
           market place - evidenced by increased volumes and revenues.

           Gross profit increases 50% on improved operating efficiencies
           The company also reported improved gross profit and margins of $1.2
           million and 73%, respectively, which is an increase of 50% and 300
           bps, respectively. The company indicated that the higher profits were
           the result of lower labor and manufacturing costs in conjunction with
           start-up costs during the first quarter of 2011 that did not occur during
           the first quarter of 2012.

           Expansion of market presence will prove upside potential
           AxoGen continues to expand its market presence nationally and
           internationally. The company recently announced expanding into the           Contact:
           Austrian market, which should provide incremental upside to its               Rich Cockrell
                                                                                         rich.cockrell@thecockrellgroup.com
           existing installed base. According to the company, it will selectively
           continue its global expansion throughout Europe during the year.              AJ Igherighe
                                                                                         aj@thecockrellgroup.com

                                                                                         1230 Peachtree Street
                                                                                         19th Floor
                                                                                         Atlanta, GA 30309
                                                                                         P 404.942.3369
                                                                                         cockrellgroup.com

                                                                                                                                     1
COCKRELL GROUP RESEARCH
                                                                                                                                Tuesday, May 15, 2012
                                          S A       H




           In a market by itself; AxoGen’s Avance technology                                   30-Day Peer Price Performance
           AxoGen’s proprietary Avance technology is a first-in-class,
           human tissue, nerve allograft product that is the only
           marketed nerve graft product currently available. This well
           positions the company to address a $1 billion dollar market
           opportunity that is currently being treated by autograft
           procedures.

ortunity exceeds $1B
              Autograft is historic goldProcedure
               Market Opportunity Autograph
                                            standard
ential
           Autograft (sural nerve)
umber of
                  32%
           •  Harvest of healthy nerve increases                                16-Apr 18-Apr 20-Apr 24-Apr 26-Apr 30-Apr 2-May 4-May 8-May 10-May 14-May
                 Trauma
              OR time, medical expenses
                 Expansion
                                  49%
tion       •  Patient loses function at the donor
                                  Trauma
otential      site 5%                                                                      AXGN             ONVO            BONE             KNSY
                  Oral
ostrate and •  27% complication rate (infection,                                           CYTX             NVIV            MDXG
                         14%
              wound healing, chronic pain)1
                    Compression
           •  Limited size and length available
                                                                                   Recent acquisition points to increased interest in
                                                                                   regenerative medicine
                                                                                   The regenerative medicine space continues to be a sector
                                                                                     Autograft
           Autograft procedures, the current “Gold Standard” (shown                of increasing interests to the Medical Technology and
                                                                                    www.ivis.org
           above) treatment for peripheral 19"    nerve discontinuities, is a      Biotechnology industries. Companies with innovative and
           procedureal, Am J Surg 1993 the patients nerve is retrieved from
             1. Rappaport et whereby                                               commercially viable technologies continue to be cherry
           another part of its body and is used to replace damaged                 picked by mega-cap conglomerates such as Johnson and
           nerves. Complications stemming from these procedure                     Johnson (JNJ), Shire Pharmaceuticals (SHPGY) and Royal
                                                                                                 8"
           generally leaves the patient without function and sensation             DSM (DSM).
           at the harvested site. Furthermore, the procedure creates
           a secondary surgery on the patient to harvest the nerve.                Kensey Nash (KNSY), a medical device company primarily
           This can lead to chronic pain and wound healing                         focused on regenerative medicine utilizing a proprietary
           complications as a result of infection. AxoGen’s Avance                 collagen and synthetic polymer technology, entered into a
           technology mitigates these complications.                               definitive agreement with Royal DSM (RDSMY.PK) to be
                                                                                   acquired for $38.50 per share in cash. This represented a
           Current share price below analysts price targets                        33% premium and nearly 4.0 times 2012 revenue
           AxoGen shares closed at $3.79, which is below the analyst               consensus estimates.
           consensus of $6.25 and represents a 64% premium.
           AxoGen’s one-month performance is +49%, which is                        We expect M&A activity in this space to continue as
           significantly higher than its regenerative medicine peer                 companies with FDA cleared and approved technologies
           group, (BONE) -29%, ((KNSY) +36%, (ONVO) +28%,                          continue to demonstrate strong commercial growth.
           (CYTX) +28%, (NVIV.OB) -7% and (MDXG.OB) +7%.




                                                                                   I




                                                                                                                                                       2
COCKRELL GROUP RESEARCH
                                                                                                             Tuesday, May 15, 2012




Disclosure Section
 COCKRELL GROUP does and seeks to do business with companies covered in COCKRELL GROUP Research. As a result,
 investors should be aware that the firm may have a conflict of interest that could affect the objectivity of COCKRELL GROUP
 Research. Investors should consider COCKRELL GROUP Research as only a single factor in making their investment
 decision.

 Certification
 The following analysts hereby certify that their views about the companies and their securities discussed in this report are
 accurately expressed and that they have not received and will not receive direct or indirect compensation in exchange for
 expressing specific recommendations or views in this report.

 Unless otherwise stated, the individuals listed on the cover page of this report are research analysts




                                                                                                                                3

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AXGN Update 05.14.12

  • 1. S A H Healthcare Update MAY 15, 2012 Outlook Positive Record 1Q Sales; Nerve Regeneration Gaining AxoGen, Inc. Traction OTCBB AXGN.OB Summary and Recommendation Analysts We reiterate our positive outlook on AxoGen, Inc. (AXGN.OB) shares Price Target* $5.25 given the company’s level of execution and progress demonstrated Analysts Rating* BUY within sales and marketing. The company reported record 1Q12 Current Px $3.79 revenues of $1.7 million, which was ahead of consensus estimates of $1.6 million. 52-Week High $4.00 52-Week Low $1.10 AxoGen, Inc. is an emerging regenerative medicine company focused Shares Out. (mm) 11.06 on the commercialization of its portfolio of proprietary products and Float (mm) 4.40 technologies for peripheral nerve reconstruction and regeneration. Market Cap (mm) $41.9 Total Debt (mm) $5.0 The company’s portfolio of regenerative technology for peripheral Cash (mm) $5.6 nerve repair provides it an opportunity to participate in a market EV (mm) $42.5 estimated to be $1 billion. FYE Dec 1Q12 revenue growth demonstrate increased penetration AxoGen reported record revenues of $1.7 million, an increase of 47% 2011 2012E* 2013E* over 1Q11 revenues of $1.1 million and ahead of FirstCall consensus Revenues (mm) $4.8 $9.3 $20.4 estimates of $1.6 million. Increased penetration into the companies Gross Profit (mm) $2.4 $6.6 $17.1 key accounts attributed to higher results. The company also Gross Margin 51% 71% 84% continues to expand its sales force, which increased to 16 direct representatives and 21 independent sales representatives. From all EPS ($2.8) ($0.68) ($0.23) indications, it is apparent that AXGN has begun to yield the benefits *All estimates including price target and rating are associated with a maturing sales force that is garnering traction in the based on FirstCall analyst consensus. market place - evidenced by increased volumes and revenues. Gross profit increases 50% on improved operating efficiencies The company also reported improved gross profit and margins of $1.2 million and 73%, respectively, which is an increase of 50% and 300 bps, respectively. The company indicated that the higher profits were the result of lower labor and manufacturing costs in conjunction with start-up costs during the first quarter of 2011 that did not occur during the first quarter of 2012. Expansion of market presence will prove upside potential AxoGen continues to expand its market presence nationally and internationally. The company recently announced expanding into the Contact: Austrian market, which should provide incremental upside to its Rich Cockrell rich.cockrell@thecockrellgroup.com existing installed base. According to the company, it will selectively continue its global expansion throughout Europe during the year. AJ Igherighe aj@thecockrellgroup.com 1230 Peachtree Street 19th Floor Atlanta, GA 30309 P 404.942.3369 cockrellgroup.com 1
  • 2. COCKRELL GROUP RESEARCH Tuesday, May 15, 2012 S A H In a market by itself; AxoGen’s Avance technology 30-Day Peer Price Performance AxoGen’s proprietary Avance technology is a first-in-class, human tissue, nerve allograft product that is the only marketed nerve graft product currently available. This well positions the company to address a $1 billion dollar market opportunity that is currently being treated by autograft procedures. ortunity exceeds $1B Autograft is historic goldProcedure Market Opportunity Autograph standard ential Autograft (sural nerve) umber of 32% •  Harvest of healthy nerve increases 16-Apr 18-Apr 20-Apr 24-Apr 26-Apr 30-Apr 2-May 4-May 8-May 10-May 14-May Trauma OR time, medical expenses Expansion 49% tion •  Patient loses function at the donor Trauma otential site 5% AXGN ONVO BONE KNSY Oral ostrate and •  27% complication rate (infection, CYTX NVIV MDXG 14% wound healing, chronic pain)1 Compression •  Limited size and length available Recent acquisition points to increased interest in regenerative medicine The regenerative medicine space continues to be a sector Autograft Autograft procedures, the current “Gold Standard” (shown of increasing interests to the Medical Technology and www.ivis.org above) treatment for peripheral 19" nerve discontinuities, is a Biotechnology industries. Companies with innovative and procedureal, Am J Surg 1993 the patients nerve is retrieved from 1. Rappaport et whereby commercially viable technologies continue to be cherry another part of its body and is used to replace damaged picked by mega-cap conglomerates such as Johnson and nerves. Complications stemming from these procedure Johnson (JNJ), Shire Pharmaceuticals (SHPGY) and Royal 8" generally leaves the patient without function and sensation DSM (DSM). at the harvested site. Furthermore, the procedure creates a secondary surgery on the patient to harvest the nerve. Kensey Nash (KNSY), a medical device company primarily This can lead to chronic pain and wound healing focused on regenerative medicine utilizing a proprietary complications as a result of infection. AxoGen’s Avance collagen and synthetic polymer technology, entered into a technology mitigates these complications. definitive agreement with Royal DSM (RDSMY.PK) to be acquired for $38.50 per share in cash. This represented a Current share price below analysts price targets 33% premium and nearly 4.0 times 2012 revenue AxoGen shares closed at $3.79, which is below the analyst consensus estimates. consensus of $6.25 and represents a 64% premium. AxoGen’s one-month performance is +49%, which is We expect M&A activity in this space to continue as significantly higher than its regenerative medicine peer companies with FDA cleared and approved technologies group, (BONE) -29%, ((KNSY) +36%, (ONVO) +28%, continue to demonstrate strong commercial growth. (CYTX) +28%, (NVIV.OB) -7% and (MDXG.OB) +7%. I 2
  • 3. COCKRELL GROUP RESEARCH Tuesday, May 15, 2012 Disclosure Section COCKRELL GROUP does and seeks to do business with companies covered in COCKRELL GROUP Research. As a result, investors should be aware that the firm may have a conflict of interest that could affect the objectivity of COCKRELL GROUP Research. Investors should consider COCKRELL GROUP Research as only a single factor in making their investment decision. Certification The following analysts hereby certify that their views about the companies and their securities discussed in this report are accurately expressed and that they have not received and will not receive direct or indirect compensation in exchange for expressing specific recommendations or views in this report. Unless otherwise stated, the individuals listed on the cover page of this report are research analysts 3