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EPITHELIUM
Maj Rishi Pokhrel
Dept of anatomy
NAIHS
www.slideshare.net
Histology?
• Microscopic anatomy?
At the end of this class you should be able to ..
• Define epithelium
• Classify epithelium with examples
• Correlate epit...
INTRODUCTION
• Primary tissue
• Epi - Upon, Thelia - Projection, Nipple
PAPILLA/ PROJECTION
DEFINITION: layer (s) of cells that covers body surfaces,
lines body cavities or constitute glands
DEVELOPMENT
• From all three germ layers
• Ectoderm - skin, mouth, nose, anal canal
• Endoderm - GIT, glands, resp tract, ...
CHIEF CHARACTERS
• Predominantly cellular
• Adhesion
• Basement membrane
» Basal lamina
» Reticular lamina
• Avascular
• C...
FUNCTIONS
•Secretion- columnar epithelium of stomach and gastric
gland
•Absorption- columnar epithelium in intestine and P...
CLASSIFICATION
EPITHELIUM
UNILAMINAR
(SIMPLE)
MULTILAMINAR
(STRATIFIED)
SQUAMOUS
COLUMNAR
CUBOIDAL
STR SQUAMOUS
STR COLUMN...
Simple squamous epithelium
•A single layer of flattened cell ( “pavement”) disc shaped central nuclei
•Thin cytoplasm
SIMPLE CUBOIDAL EPITHELIUM
SIMPLE COLUMNAR EPITELIUM
COLUMNAR EPITHELIUM WITH MICROVILLI
Gall bladder
CILIATED COLOUMNAR EPITHELIUM
Brush border
CILIATED COLOUMNAR EPITHELIUM
GOBLET CELL
PSEUDOSTRATIFIED
COLUMNAR
NON-CILIATED
PSEUDOSTRATIFIED
COLUMNAR CILIATED
PSEUDOSTRATIFIED COLUMNAR WITH
STEREOCILIA
Epididymis
STR SQUAMOUS NON KER EPITHELIUM
STR SQUAMOUS KER EPITHELIUM
STR CUBOIDAL EPITHELIUM
STR CUBOIDAL EPITHELIUM
STRATIFIED COLUMNAR
TRANSITIONAL EPITHELIUM
TRANSITIONAL EPITHELIUM
Assignment
• Cell junctions??
?
CONTACTS BETWEEN ADJOINING
CELLS
CLASSIFICATN OF CELL CONTACTS
1. UNSPECIALISED CONTACTS
2. SPECIALISED JUNCTIONAL STRS
A....
INTERCELLULAR JUNCTIONS
(JUNCTIONAL COMPLEXES)
ZONULA
OCCLUDENS
ZONULA
ADHERENS
DESMOSOME
HEMIDESMOSOME
GAP
JUNCTION
UNSPECIALISED CONTACT
• Cell adhesion molecules
• In intercellular gap
• Glycoprotein & proteoglycan
ZONULA OCCLUDENS
•Apical part of cell
•Band or belt
•Sealing effect
•Eg. Intestine, urinary bladder
DESMOSOME ZONULA ADHERENS
ANCHORING JUNCTIONS
GAP JUNCTION
•Lateral surface of epithelial cells
•Numerous transmembrane protein channels
•Permit inorganic ions, small m...
TEST
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Epithelium

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general anatomy class on epitheloum

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Epithelium

  1. 1. EPITHELIUM Maj Rishi Pokhrel Dept of anatomy NAIHS www.slideshare.net
  2. 2. Histology? • Microscopic anatomy?
  3. 3. At the end of this class you should be able to .. • Define epithelium • Classify epithelium with examples • Correlate epithelium with their function
  4. 4. INTRODUCTION • Primary tissue • Epi - Upon, Thelia - Projection, Nipple PAPILLA/ PROJECTION
  5. 5. DEFINITION: layer (s) of cells that covers body surfaces, lines body cavities or constitute glands
  6. 6. DEVELOPMENT • From all three germ layers • Ectoderm - skin, mouth, nose, anal canal • Endoderm - GIT, glands, resp tract, distal parts of GU tract • Mesoderm - body cavities, endothelium, proximal parts of GU tract
  7. 7. CHIEF CHARACTERS • Predominantly cellular • Adhesion • Basement membrane » Basal lamina » Reticular lamina • Avascular • Cell shape • Regeneration - tumors common
  8. 8. FUNCTIONS •Secretion- columnar epithelium of stomach and gastric gland •Absorption- columnar epithelium in intestine and PCT in kidney •Transportation- material of cells along the surface of epithelium by motile cilia •Protection- skin and urothelium in bladder •Receptor- taste and olfaction •Lubrication
  9. 9. CLASSIFICATION EPITHELIUM UNILAMINAR (SIMPLE) MULTILAMINAR (STRATIFIED) SQUAMOUS COLUMNAR CUBOIDAL STR SQUAMOUS STR COLUMNAR STR CUBOIDAL TRANSITIONAL PSEUDOSTRATIFIED Specialization
  10. 10. Simple squamous epithelium •A single layer of flattened cell ( “pavement”) disc shaped central nuclei •Thin cytoplasm
  11. 11. SIMPLE CUBOIDAL EPITHELIUM
  12. 12. SIMPLE COLUMNAR EPITELIUM
  13. 13. COLUMNAR EPITHELIUM WITH MICROVILLI Gall bladder
  14. 14. CILIATED COLOUMNAR EPITHELIUM Brush border
  15. 15. CILIATED COLOUMNAR EPITHELIUM
  16. 16. GOBLET CELL
  17. 17. PSEUDOSTRATIFIED COLUMNAR NON-CILIATED PSEUDOSTRATIFIED COLUMNAR CILIATED
  18. 18. PSEUDOSTRATIFIED COLUMNAR WITH STEREOCILIA Epididymis
  19. 19. STR SQUAMOUS NON KER EPITHELIUM
  20. 20. STR SQUAMOUS KER EPITHELIUM
  21. 21. STR CUBOIDAL EPITHELIUM
  22. 22. STR CUBOIDAL EPITHELIUM
  23. 23. STRATIFIED COLUMNAR
  24. 24. TRANSITIONAL EPITHELIUM
  25. 25. TRANSITIONAL EPITHELIUM
  26. 26. Assignment • Cell junctions??
  27. 27. ?
  28. 28. CONTACTS BETWEEN ADJOINING CELLS CLASSIFICATN OF CELL CONTACTS 1. UNSPECIALISED CONTACTS 2. SPECIALISED JUNCTIONAL STRS A. Occluding jns or Zonula occludens or tight jns B. Anchoring jns or Adhesive jns • Adhesive belts or Zonula adherens • Adhesive strips or Fascia adherens • Adhesive spot (Desmosomes, Maculae adherens) A. Communicating jns or gap jns
  29. 29. INTERCELLULAR JUNCTIONS (JUNCTIONAL COMPLEXES) ZONULA OCCLUDENS ZONULA ADHERENS DESMOSOME HEMIDESMOSOME GAP JUNCTION
  30. 30. UNSPECIALISED CONTACT • Cell adhesion molecules • In intercellular gap • Glycoprotein & proteoglycan
  31. 31. ZONULA OCCLUDENS •Apical part of cell •Band or belt •Sealing effect •Eg. Intestine, urinary bladder
  32. 32. DESMOSOME ZONULA ADHERENS ANCHORING JUNCTIONS
  33. 33. GAP JUNCTION •Lateral surface of epithelial cells •Numerous transmembrane protein channels •Permit inorganic ions, small molecules, nutrients, chem messengers
  34. 34. TEST

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