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Skeletal System ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Skeletal System ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bone Classification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bone Classification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Femur   Carpal Bones
Bone Classification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Sternum Sphenoid Bone
Bone Structure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],Above:  Note the relationship btwn the compact and spongy bone. Below:  Close up of spongy bone.
Note the gross differences between the spongy bone and the compact bone in the above photo. Do you see the trabeculae?
Compare compact and spongy bone as viewed with the light microscope
Bone Structure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The blue arrows indicate the osteoblasts.  The yellow arrows indicate the bone matrix they’ve just secreted.
Bone Structure ,[object Object],[object Object],[object Object],[object Object],[object Object],Yellow arrows indicate osteocytes – notice how they are surrounded by the pinkish bone matrix. Blue arrow shows an osteoblast in the process of becoming an osteocyte. On the right, notice how the osteocyte is “trapped” within the pink matrix
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Bone Structure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],Three-dimensional array of collagen molecules. The rod-shaped molecules lie in a staggered arrangement which acts as a template for bone mineralization. Bone mineral is laid down in the gaps.  Note collagen fibers in longitudinal & cross section and how they occupy space btwn the black bone cells.
This bone: a.  Has been demineralized b.  Has had its organic component removed
Long Bone Structure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Long Bone Structure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Long Bone Structure ,[object Object],[object Object],[object Object]
Structure of Short, Irregular, and Flat Bones ,[object Object],[object Object],[object Object],[object Object]
Bone Marrow ,[object Object],[object Object],[object Object],[object Object],[object Object],Notice the red marrow and the compact bone
Distribution of Marrow ,[object Object],[object Object],[object Object],[object Object],Note the compact bone on the bottom and marrow on the bottom.
Microscopic Structure of Compact Bone ,[object Object],[object Object],The diagram below represents a long bone shaft in cross-section.  Each yellow circle represents an osteon.  The blue represents additional matrix filling in the space btwn osteons.  The white in the middle is the marrow cavity.
Osteons ,[object Object],[object Object],[object Object],[object Object]
[object Object]
Osteons ,[object Object],[object Object]
[object Object],[object Object]
 
Here, we have a close up and a far away view of compact bone.  You should be able to identify haversian canals, concentric lamellae, interstitial lamellae, lacunae, and canaliculi.
Microscopic Structure of Spongy Bone ,[object Object],[object Object],[object Object],[object Object],[object Object]
Bone Development ,[object Object],[object Object],[object Object],[object Object]
Formation of the Bony Skeleton ,[object Object],[object Object],[object Object],[object Object]
Intramembranous Ossification ,[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object]
Endochondral Ossification ,[object Object],[object Object],[object Object],[object Object]
Endochondral Ossification – Step 1 ,[object Object],[object Object]
Endochondral Ossification – Step 2 ,[object Object],[object Object]
Endochondral Ossification – Step 3 ,[object Object],[object Object],[object Object],[object Object],Notice the primary ossification centers in the thigh and forearm bones of the above fetus.
Endochondral Ossification – Step 4 ,[object Object],[object Object]
Endochondral Ossification – Step 5 ,[object Object],[object Object],Articular cartilage Epiphyseal plate
 
Growth in Bone Length ,[object Object]
[object Object],At puberty, growth in bone length is increased dramatically by the combined activities of growth hormone, thyroid hormone, and the sex hormones.
Growth in Bone Thickness ,[object Object],[object Object],[object Object]
Fractures ,[object Object],[object Object],[object Object]
Fracture Repair ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],Fracture Repair ,[object Object],[object Object],[object Object]
Fracture Types ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
What kind of fracture is this? It’s kind of tough to tell, but this is a _ _ _ _ _ _  fracture .
Bone Remodeling ,[object Object],[object Object],[object Object]
Check out the mechanism of remodeling on the right! Why might you suspect someone whose been a powerlifter for 15 years to have heavy, massive bones, especially at the point of muscle insertion? Astronauts tend to experience bone atrophy after they’re in space for an extended period of time.  Why?
Nutritional Effects on Bone ,[object Object],[object Object],[object Object]
Hormonal Effects on Bone ,[object Object],[object Object],[object Object],[object Object]
Hormonal Effects on Bone ,[object Object],[object Object],[object Object]
Hormonal Effects on Bone ,[object Object],[object Object],[object Object],[object Object],[object Object]
Calcitonin ,[object Object],[object Object],[object Object],[object Object],Notice the thyroid follicles on the right.  The arrow indicates a C cell
Calcitonin Negative Feedback Loop Increased Blood [Ca 2+ ] Increased calcitonin release from thyroid C cells. Increased osteoblast activity Decreased osteoclast activity
Parathyroid Hormone ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Increased PTH release by parathyroid gland Binds to osteoblast causing decreased osteoblast activity and release of osteoclast-stimulating factor OSF causes increased osteoclast activity Decreased bone deposition and increased bone resorption Increased calcitriol synthesis Increased intestinal Ca 2+  absorption Decreased Ca 2+  excretion Increased Blood [Ca 2+ ] Decreased Blood [Ca 2+ ]
Clinical Conditions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],What about the above x-ray is indicative of rickets?
Clinical Conditions ,[object Object],[object Object],[object Object],[object Object]
Clinical Conditions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Conditions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Bone tissue to skeletal system ppt

  • 1.
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8. Note the gross differences between the spongy bone and the compact bone in the above photo. Do you see the trabeculae?
  • 9. Compare compact and spongy bone as viewed with the light microscope
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16. This bone: a. Has been demineralized b. Has had its organic component removed
  • 17.
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  • 19.
  • 20.
  • 21.
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.
  • 27.
  • 28.  
  • 29. Here, we have a close up and a far away view of compact bone. You should be able to identify haversian canals, concentric lamellae, interstitial lamellae, lacunae, and canaliculi.
  • 30.
  • 31.
  • 32.
  • 33.
  • 34.
  • 35.
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  • 43.  
  • 44.
  • 45.
  • 46.
  • 47.
  • 48.
  • 49.
  • 50.
  • 51.  
  • 52. What kind of fracture is this? It’s kind of tough to tell, but this is a _ _ _ _ _ _ fracture .
  • 53.
  • 54. Check out the mechanism of remodeling on the right! Why might you suspect someone whose been a powerlifter for 15 years to have heavy, massive bones, especially at the point of muscle insertion? Astronauts tend to experience bone atrophy after they’re in space for an extended period of time. Why?
  • 55.
  • 56.
  • 57.
  • 58.
  • 59.
  • 60. Calcitonin Negative Feedback Loop Increased Blood [Ca 2+ ] Increased calcitonin release from thyroid C cells. Increased osteoblast activity Decreased osteoclast activity
  • 61.
  • 62. Increased PTH release by parathyroid gland Binds to osteoblast causing decreased osteoblast activity and release of osteoclast-stimulating factor OSF causes increased osteoclast activity Decreased bone deposition and increased bone resorption Increased calcitriol synthesis Increased intestinal Ca 2+ absorption Decreased Ca 2+ excretion Increased Blood [Ca 2+ ] Decreased Blood [Ca 2+ ]
  • 63.
  • 64.
  • 65.
  • 66.