1.
THE STUDY OF EFFECT OF
IMMUNOSUPPRESSANTS
DURING ORGAN
TRANSPLANT
BY- SAUBHAGYA SAJWAN
ROLL NO. 118
ENROLLMENT NO.- A0504120025

2.
WHAT ARE IMMUNOSUPPRESSANTS?
 Immunosuppressants are drugs or medicines that lower the body's ability to
reject a transplanted organ. Another term for these drugs is anti-rejection drugs.
 There are 2 types of immunosuppressants:
1.Induction drugs: Powerful antirejection medicine used at the time of transplant
2.Maintenance drugs: Antirejection medications used for the long term.
Think of a real estate mortgage; the down payment is like the induction drug and
the monthly payments are like maintenance drugs. If the down payment is good
enough you can lower the monthly payments, the same as for immunosuppression.

3.
WHAT ARE IMMUNOSUPPRESSANTS
USED FOR?
 For example if you go through a kidney transplant, the body knows that this new
kidney is certainly foreign (that it was never originally a part of your body). Your
body is bound to attack this new kidney and will definitely try to damage or
better is to destroy it. This is where immunosuppressant drugs come into play
which help to suppress ones body's capability to do this. The major goal here is to
modify these drugs to prevent rejection and to reduce any side effects of the
drugs.

4.
ORGAN TRANSPLANTATION
 An organ transplant is a surgical operation in which a failed or a damaged organ of a particular
human body is purposely removed and replaced with a fully functional organ.This organ which is
replaced can be acquired from a number of option for example a deceased donor , a living donor
, or an animal. Examples of some organs that can be transplanted-
1. Heart
2. Kidneys
3. Liver
4. Lungs
5. Pancreas
6. Intestine
7. Thymus

5.
TYPES OF ORGAN TRANSPLANTS
1. Autograft
2. Allograft
3. Isograft
4. Xenograft
5. Split Transplant
6. Domino Transplant

6.
CLASSIFICATION OF
IMMUNOSUPPRESSANT DRUGS
 Classification Immunosuppressive drugs into 5 groups:
1. Glucocorticoids
2. Cytostatic
3. Antibodies
4. Drugs acting on Immunophilins
5. Other drugs