Borrelia

BORRELIA G.HARIPRASAD M.Sc.,(Med micro),M.phil., Lecturer in Microbiology Department of Microbiology Thoothukudi Govt. Medical College Thoothukudi

Spirochaete with wide-opened coils Stain easily with ordinary stains i.e. Gram stain Gram negative spiral rods Some borrelia occur as mouth commensals

Species of medical concern ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Relapsing fever ,[object Object],[object Object],[object Object],[object Object],TICK BODY LOUSE

Pathogenesis ,[object Object],[object Object],[object Object],[object Object],[object Object]

Laboratory diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object]

TREATMENT ,[object Object],[object Object],[object Object],[object Object],Prophylaxis Control of vectors ( louse and tick) Maintenance of good personal hygiene

Vincent’s angina ,[object Object],[object Object],[object Object],[object Object],[object Object]

Lab diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Fusiform rods

CULTURE ,[object Object],[object Object],[object Object],[object Object],[object Object]

LYME DISEASE ,[object Object],[object Object],First case identified in Lyme, USA – hence the name “Lyme disease”

DEER - RESERVOIR IXODID TICK Tick gets borrelia when feed deer’s blood BORRELIA

Erythema migrans – forms where tick bites TICK FEEDING ON HUMAN

DISSEMINATED INFECTION ,[object Object],[object Object],[object Object],[object Object],[object Object]

PERSISTENT INFECTION ,[object Object],[object Object],[object Object],[object Object],[object Object]

Laboratory diagnosis BLOOD SMEAR EXAMINATION AFTER GIEMSA STAINING DARK FIELD MICROSCOPY

Fluorescent microscopy Borrelia-specific antibody tagged with fluorescent dyes are added If borrelia binds with such antibodies, they can fluoresce like this!!!!!!!!!

CULTURE ,[object Object],[object Object],[object Object]

TREATMENT ,[object Object],[object Object],[object Object],NO VACCINES !!!!!!!!!!!!

Borrelia

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Borrelia