2. As the title suggests, this presentation is a survey of current structural and behavioral
Alzmeimer’s Disease (AD) signs, causes and treatments. Structural issues concern
effects of the disease on brain structures such as nerve cells and brain tissue. Behavioral
issues include effects on memory and personality.
First, it describes AD itself in general terms and the scope of the impact the disease has
on global society. These impacts are financially, emotionally, and biologically substantial.
Next, I show the genetic and non-genetic risk factors for developingAD.
Then, it examines AD pathophysiology, including the mechanisms by which AD inflicts its
terrible toll. After delineating the stages of AD, it presents two case studies of afflicted
indivuduals. Are you able to note the behavioral issues?
Finally, it surveys and analyzes the currently approved drug therapies, including
psychotropic drugs for psychotic symptoms. In addition, it examines and looks forward
to potential immunotherapies. And, lastly, it critiques some of the non-approved drug
treatments and trials.
3. Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by
the accrual of neuritic plaques and neurofibrillary tangles that result in a disruption of
neuronal function and which causes cognitive and behavioral dysfunction (Braak &
Braak, 1991).
AD causes an insidious and progressive loss of cognitive function and independence,
taking a heavy personal and financial toll on the patient and the family. Alzheimer's
disease, Pick's disease, and other organic forms of dementia are generally considered
irreversible, progressive, and incurable.
AD is the most common cause of dementia among older people. Dementia is a loss of
mental ability severe enough to interfere with normal activities of daily living, lasting
more than six months, not present since birth, and not associated with a loss or
alteration of consciousness.
Dementia is a group of symptoms caused by gradual death of brain cells. The loss of cognitive
abilities that occurs with dementia leads to impairments in memory, reasoning, planning, and
behavior. While the overwhelming number of people with dementia are elderly, dementia is
not an inevitable part of aging; instead, dementia is caused by specific brain diseases.
4. In 2010, an estimated 36 million people worldwide were living with dementia—a
number that is projected to increase to 66 million in 2030, and 115 million in 2050. 1 to
3 percent of people older than 65 who have normal cognition will develop AD in any one
year.
According to the World Alzheimer Report, the worldwide cost of dementia is estimated
at USD $604 billion for 2010, and according to one model, this cost has increased by
34% between 2005 and 2009.
Alzheimer’s disease is the 6th leading cause of death in the United States and the 5th
leading cause of death for those aged 65 and older. And, Alzheimer’s is the only cause
of death among the top 10 in America without a way to prevent, cure or even slow its
progression.
Approximately 5% of all persons over age 70 have AD; this proportion raises to 25%–45%
in “oldest old” (>85 years) individuals. About 10% of AD patients develop symptoms
before age 65, more often in their 40 s or 50 s.
5. Deaths from Alzheimer’s increased 66 percent between 2000 and 2008, while deaths
from other major diseases, including the number one cause of death (heart disease),
decreased.
Due to the physical and emotional toll of caregiving on their own health, Alzheimer’s
and dementia caregivers had $8.7 billion in additional health care costs in 2011.
An estimated 800,000 individuals with Alzheimer’s (more than one in seven) live alone.
Of those who live alone, up to half of them do not have an identifiable caregiver.
People with Alzheimer’s and other dementias who live alone are exposed to higher risks
– including inadequate self-care, malnutrition, untreated medical conditions, falls,
wandering from home unattended, and accidental deaths – compared to those who do
not live alone.
6.
7. Age: Mitochondria become more susceptible to damage; Inflammation (swelling)
increases, which can injure nerve cells, such as after a head injury;
Oxidative stress, which is caused by the release of molecules called free radicals from
normal cellular processes, increases.
Education level: Research suggests the more years of formal education one has, the less
likely one is to develop Alzheimer's. Some experts theorize that longer education may
produce a denser network of synapses. This may create a kind of "neural reserve" that
enables people to compensate longer for the early brain changes.
Race and Ethnicity: African-Americans and Hispanics are about twice as likely to
develop Alzheimer’s as white Americans of the same age. While the reasons for this are
unclear, there is some speculation that it may have to do with the fact that these groups
have a higher incidence of high blood pressure and diabetes.
High blood pressure and high cholesterol: There is growing evidence that many of the
well-established risk factors for cardiovascular disease, including high cholesterol and
high blood pressure, may also be risk factors for Alzheimer's disease.
8. Diabetes: Diabetes has been implicated as a risk factor for eventually developing
Alzheimer's disease. There are many ongoing studies attempting to understand the
connection, and some diabetes drugs appear to slow the cognitive decline associated
with Alzheimer's disease.
Head trauma: Some studies have found that Alzheimer's occurs more often in people
who have suffered traumatic brain injury earlier in life. A history of head injury is clearly
a risk factor for Alzheimer's in people who carry the APOE-4 Alzheimer's gene.
Diet: Obesisty doubled the risk of developing AD; Foods high in fat and sugar, as well as
larger amounts of red and processed meats increased risk versus lean meats (fish and
poultry) and more fruits and vegetables.
The cause of AD is not clear. Your genes and environmental factors seem to play a role.
Aluminum, lead, and mercury in the brain is no longer believed to be a cause of AD.
9.
10. The only identified deterministic factors for the development of AD are the presence of
mutations in one of three genes – amyloid precursor protein (APP), presenilin 1 (PSEN1)
or presenilin 2 (PSEN2) – or duplication of APP.
Even if only one of these genes that are inherited from a parent contains a mutation, the
person will almost inevitably develop early-onset AD. (≈100%)
You are more likely to get Alzheimer's disease (AD) if you:
• Have a close blood relative, such as a brother, sister, or parent with AD.
• Have certain genes linked to AD, such as APOE epsilon4 allele
This gene, called APOE, produces a protein called apolipoprotein E. APOE comes in
several forms, or alleles—ε2, ε3, and ε4. APOE ε4 occurs in about 40 percent of all
people who develop late-onset AD and is present in about 25 to 30 percent of the
population.
11. Notably, the cognitive declines and functional changes in APOE ε4 carriers tend to
become most evident after age 65 (Jorm et al., 2007; Mondadori et al., 2006b),
suggesting that the negative effects of the APOE ε4 allele accelerate with age.
The genetics of late-onset Alzheimer’s disease (LOAD) has taken impressive steps
forwards in the last few years. To date, more than six-hundred genes have been linked
to the disorder. However, only a minority of them are supported by a sufficient level of
evidence.
The quality of studies was assessed using criteria such as size of research samples,
heterogeneity across studies, and protection from publication bias. This produced a list
of 15 top-rated genes: APOE, CLU, PICALM, EXOC3L2, BIN1, CR1, SORL1, TNK1, IL8, LDLR,
CST3, CHRNB2, SORCS1, TNF, and CCR2.
A systematic analysis of gene ontology terms associated with each marker showed that
most genes were implicated in cholesterol metabolism, intracellular transport of beta-
amyloid precursor, and autophagy of damaged organelles. Further analysis highlights
the role of inflammatory response in AD pathogenesis.
12. The brains of people with AD have an abundance of two abnormal structures—amyloid
plaques and neurofibrillary tangles—that are made of misfolded proteins . The third main
feature of AD is the loss of connections between cells. This leads to diminished cell function
and cell death.
Accumulation of toxic beta amyloid with the formation of extracellular betaamyloid-
containing plaques: We still do not know whether amyloid plaques themselves cause
AD or whether they are a by-product of the AD process. However, genetic mutations can
increase production of beta-amyloid and can cause rare, inherited forms of AD.
Development of intracellular neurofibrillary tangles: Tangles are abnormal collections
of twisted protein threads found inside nerve cells. The chief component of tangles is a
protein called tau.
Neuronal degeneration: The AD process not only inhibits communication between
neurons but can also damage neurons to the point that they cannot function properly
and eventually die. As neurons die throughout the brain, affected regions begin to shrink
in a process called brain atrophy.
13. Amyloid precursor protein (APP) becomes
embedded in cell surface
Specific enzymes snip, or cleave, APP into
discrete fragments, some are Beta-amyloid
(Aβ) peptides
Aggregates of two, three, four, or even up to a
dozen beta-amyloid peptides are called
oligomers.
As the process continues, oligomers grow
larger, becoming entities called protofibrils and
fibrils. Eventually, other proteins and cellular
material are added, and these increasingly
insoluble entities combine to become the well-
known plaques that are characteristic of AD.
14. Multiple lines of evidence now suggest that it is not just the presence of Aβ but the
production and/or deposition of toxic forms of beta amyloid, along with the slowing of Aβ
clearance, that act as the central and primary events in AD pathogenesis, while neurofibrillary
tangle formation and neuronal cell death occur downstream in this amyloid cascade.
Elevated levels of tau protein in the cerebrospinal fluid (CSF) are markers of active
neuronal degeneration, while levels of abnormally phosphorylated tau (P-tau) appear to
correlate with the quantity of neurofibrillary tangles in the brain, suggesting that CSF P-
tau may serve as an in vivo biomarker of the neurofibrillary pathology of AD.
Cells and compounds known to be involved in inflammation are found in AD plaques.
Some researchers think that components of the inflammatory process may play a role in
AD. Other players in the aging process that may be important in AD are free radicals,
oxygen or nitrogen molecules that combine easily with other molecules.
Betaamyloid deposition within the CNS would bring about the activation of microglia
and thus initiate a proinflammatory cascade leading to release potentially neurotoxic
substances (cytokines; chemokines; reactive oxygen andnitrogen species; proteolytic
enzymes) and to amplify neural damage.
15. Healthy neurons are internally supported in part by
structures called microtubules, which help transport
nutrients and other cellular components, from the cell body
down the axon.
As a result of “hyperphosphorylation,” tau disengages from
the microtubules and begins to come together with other
tau threads.
These tau threads form structures called paired helical
filaments, which can become enmeshed with one another,
forming tangles within the cell.
The microtubules can disintegrate in the process, collapsing
the neuron’s internal transport network. This collapse
damages the ability of neurons to communicate with each
other.
16. On this slice, the atrophic hippocampus and amygdala can be seen. These
structures subserve memory function, and are the sites of major damage in
Alzheimer's disease.
17. Here is a mid-ventricular slice which demonstrates the commonest finding in
functional imaging of Alzheimer's disease. The dark blue regions in the
parietal lobes represent areas of decreased blood flow or perfusion. This
reduction in blood flow is due in part to the underlying atrophy, in part to the
presence of diseased brain, and in part to the functional "disconnection" of
this from other brain regions affected by the disease.
18. The association cortex of the parietal lobes is often severely affected, as
illustrated in this case.
19. MRI and PET scan image overlay for corresponding slice showing perfusion
and atrophy in the associated areas of reduced blood flow.
20. Scientists developed a radiolabeled compound
called Pittsburgh Compound B (PiB).
PiB binds to beta-amyloid plaques in the brain and
can be imaged using PET scans.
Initial studies showed that people with AD take up
more PiB in their brains than do cognitively healthy
older people.
Since then, scientists have found high levels of PiB
in some cognitively healthy people, suggesting that
the damage from beta amyloid may already be
underway.
In this PET scan, the red and yellow colors
indicate that PiB uptake is higher in the
brain of the person with AD than in the
cognitively healthy person.
21. The compensatory hypothesis is an explanation of differential regional (brain regions)
activity seen in at-risk groups.
The compensatory hypothesis holds that as AD-related degenerative processes progress
the brain employs various compensatory measures to overcome these pathologic
encroachments until the decline in cognitive abilities becomes apparent and, ultimately,
daily functioning is disrupted.
Accordingly, increased functional activity has been interpreted as a compensatory
process whereby greater cognitive effort—usually reflected by increases in BOLD (blood
oxygen level)activity—is required to perform at an equivalent level compared to healthy
control groups.
Similarly, decreased activity in healthy functioning has been interpreted as evidence of
efficient processing (Mondadori et al., 2006b), whereas decreased activity in
neurodegenerative diseases appears to reflect cortical compromise or disconnection.
22. AD begins deep in the brain, in the entorhinal cortex, a brain region that is near the
hippocampus and has direct connections to it. Healthy neurons in this region begin to
work less efficiently, lose their ability to communicate, and ultimately die.
This process gradually spreads to the hippocampus, the brain region that plays a major
role in learning and is involved in converting short-term memories to long-term
memories. Affected regions begin to atrophy.
Ventricles, the fluid filled spaces inside the brain, begin to enlarge as the process
continues.
Scientists believe that these brain changes begin 10 to 20 years before any clinically
detectable signs or symptoms of forgetfulness appear. That’s why they are increasingly
interested in the very early stages of the disease process.
23. As some people grow older, they develop memory problems greater than those
expected for their age. But they do not experience the personality changes or other
problems that are characteristic of AD. These people may have a condition called mild
cognitive impairment (MCI).
People with MCI are a critically important group for research because a much higher
percentage of them go on to develop AD than do people without these memory
problems. About 8 of every 10 people who fit the definition of amnestic MCI go on to
develop AD within 7 years.
Those with MCI who had lots of trouble moving their legs and feet were more than
twice as likely to develop AD as those with good lower body function.
However, researchers are not yet able to say definitively why some people with
amnestic MCI do not progress to AD, nor can they say who will or will not go on to
develop AD.
24. As AD spreads through the brain, the number of plaques and tangles grows, shrinkage
progresses, and more and more of the cerebral cortex is affected. Memory loss
continues and changes in other cognitive abilities begin to emerge. The clinical diagnosis
of AD is usually made during this stage.
In mild AD, a person may seem to be healthy but is actually having more and more
trouble making sense of the world around him or her. The realization that something is
wrong often comes gradually to the person and his or her family.
Signs of mild AD can include: Memory loss Confusion about the location of familiar
places (getting lost begins to occur); Taking longer than before to accomplish normal
daily tasks; Trouble handling money and paying bills; Loss of spontaneity and sense of
initiative; Mood and personality changes, increased anxiety and/or aggression
Accepting these signs as something other than normal and deciding to go for diagnostic
tests can be a big hurdle for people and families.
25. By this stage, AD damage has spread to the areas of the cerebral cortex that control
language, reasoning, sensory processing, and conscious thought. Affected regions
continue to shrink, ventricles enlarge, and signs and symptoms of the disease become
more pronounced and widespread.
Behavioral problems, such as wandering and agitation, can occur. More intensive
supervision and care become necessary, which can be difficult for many spouses and
families. Some of these symptoms may become worse in the evening (a phenomenon
called “sundowning”) or during daily routines, especially bathing.
The symptoms of this stage can include: Increasing memory loss and confusion;
Inappropriate outbursts of anger; Problems recognizing friends and family members;
Difficulty with language; Restlessness, agitation, anxiety, tearfulness, wandering—
especially in the late afternoon or night. And,
Hallucinations, delusions, suspiciousness or paranoia, irritability; Loss of impulse control
(shown through undressing at inappropriate times or places or vulgar language); An
inability to carry out activities that involve multiple steps in sequence, such as dressing,
making a pot of coffee, or setting the table.
26. People with severe AD cannot recognize family and loved ones or communicate in any
way. They are completely dependent on others for care.
Symptoms can include: Weight loss; Seizures; Skin infections; Difficulty swallowing;
Groaning, moaning or grunting; Increased sleeping; Loss of bladder or bowel control.
Near the end, the person may be in bed much or all of the time. The most frequent
cause of death for people with AD is aspiration pneumonia. This type of pneumonia
develops when a person is not able to swallow properly and takes food or liquids into
the lungs instead of air.
To qualify for hospice benefits under Medicare, a physician must diagnosis the person
with Alzheimer’s disease as having less than six months to live.
27. This diagram reveals the neuropathological hallmarks of AD
that include neuritic (also ‘senile’) plaques, neurofibrillary
tangles (NFTs), and amyloid angiopathy.
Neuritic plaques are extracellular aggregates of beta(β)-
amyloid protein in a milieu of reactive astrocytes and
activated microglia.
NFTs are intraneuronal cytoplasmatic filaments composed
of hyperphosphorylated tau, frequently conjugated with
ubiquitin.
28.
29.
30. One type is the rare, early-onset Alzheimer’s disease. It usually affects people aged 30
to 60. Some cases of early-onset disease are inherited and are called familial AD (FAD).
It is acknowledged that 75% of people with AD have sporadic AD (SAD) a form of late-
onset AD (LOAD). This is most likely a multifactorial condition, which involves a
combination of genetic, lifestyle, and environmental factors. 25% is familial AD (FAD).
Early-onset AD encompasses 5% of FAD cases.
Early-onset FAD is inherited in an autosomal dominant manner and is caused by
mutations in one of these three genes: APP, PSEN1, and PSEN2.
The principal neuropathological changes in ADAD, a form of early-onset AD, – neuronal
loss, neurofibrillary tangles, senile plaques, and cerebral amyloid angiopathy (CAA) –
mirror those seen in SAD (LOAD) providing strong support for ADAD as a model for
studying AD.
31. The other is late-onset Alzheimer’s disease (LOAD). It is by far the more common form
and occurs in those 60 and older.
As for LOAD, the only established genetic factor is apolipoprotein E (APOE). APOE
associated Alzheimer’s disease is due to a specific variation in the APOE gene called e4
allele. It is estimated that 40–65% of AD patients have at least one copy of the e4 allele.
Individuals with two e4 alleles have up to 20 times the risk of developing AD.
Nonetheless, a third of patients with AD are ApoE4 negative, and some ApoE4
homozygotes never develop the disease.
More severe medial-temporal lobe atrophy may be present in symptomatic ADAD (early
onset) carriers compared with SAD (late onset).
32. Memory loss that disrupts daily life: forgetting recently learned information, important dates
or events; asking repetitively for things; using memory aides (e.g., reminder notes or electronic
devices) or family members for things they used to handle on their own.
What’s Typical: Sometimes forgetting names or appointments,
but remembering them later.
Challenges in planning or solving problems: Some people may experience changes in their
ability to develop and follow a plan or work with numbers. They may have trouble following a
familiar recipe or keeping track of monthly bills. They may have difficulty concentrating and
take much longer to do things than they did before.
What’s Typical: Making occasional errors when balancing a
checkbook.
33. Difficulty completing familiar tasks at home, at work or at leisure: People with Alzheimer’s
often find it hard to complete daily tasks. Sometimes, people may have trouble driving to a
familiar location, managing a budget at work or remembering the rules of a favorite game.
What’s Typical: Occasionally needing help to use the settings
on a microwave or to record a television show.
Confusion with time or place: People with Alzheimer's can lose track of dates, seasons and the
passage of time. They may have trouble understanding something if it is not happening
immediately. Sometimes they may forget where they are or how they got there.
What’s Typical: Getting confused about the day of the week but
figuring it out later.
34. Trouble understanding visual images and spatial relationships: For some people, having
vision problems is a sign of Alzheimer's. They may have difficulty reading, judging distance and
determining color or contrast. In terms of perception, they may pass a mirror and think
someone else is in the room. They may not recognize their own reflection.
What’s Typical: Vision changes related to cataracts.
New problems with words in speaking or writing: People with Alzheimer's may have trouble
following or joining a conversation. They may stop in the middle of a conversation and have no
idea how to continue or they may repeat themselves. They may struggle with vocabulary, have
problems finding the right word or call things by the wrong name (e.g., calling a watch a "hand
clock").
What’s Typical: Sometimes having trouble finding the right word.
35. Misplacing things and losing the ability to retrace steps: A person with Alzheimer’s disease
may put things in unusual places. They may lose things and be unable to go back over their
steps to find them again. Sometimes, they may accuse others of stealing. This may occur more
frequently over time.
What’s Typical: Misplacing things from time to time, such as a
pair of glasses or the remote control.
Decreased or poor judgment: People with Alzheimer's may experience changes in judgment or
decision making. For example, they may use poor judgment when dealing with money, giving
large amounts to telemarketers. They may pay less attention to grooming or keeping
themselves clean.
What’s Typical: Making a bad decision once in a while.
36. Withdrawal from work or social activities: A person with Alzheimer's may start to remove
themselves from hobbies, social activities, work projects or sports. They may have trouble
keeping up with a favorite sports team or remembering how to complete a favorite hobby.
They may also avoid being social because of the changes they have experienced.
What’s Typical: Sometimes feeling weary of work, family and
social obligations.
Changes in mood and personality: The mood and personalities of people with Alzheimer's can
change. They can become confused, suspicious, depressed, fearful or anxious. They may be
easily upset at home, at work, with friends or in places where they are out of their comfort
zone.
What’s Typical: Developing very specific ways of doing things
and becoming irritable when a routine is disrupted
37. Psychosis is frequent in late onset
Alzheimer’s disease, with a median
prevalence across studies of 41%.
Psychosis significantly aggregated within
late onset Alzheimer’s disease families
suggesting that it may identify a
genetically determined subgroup.
Evidence indicates that psychosis is a
marker for more severe cognitive
impairments and a more rapidly
progressive phenotype of late onset
Alzheimer’s disease.
38. A 73 year old woman, was brought to neurological evaluation by her brother
because of a 3 year history of memory impairment. She had completed high
school and worked in a clerical position until her retirement in 1985. She had lived
alone and maintained her own home and financial affairs since the death of her
husband in 1980. The brother had begun to notice gradually worsening memory
impairment and difficulty finding words, but the patient became angry at the
suggestion that she may have a progressive impairment. Others had noted
decline in housekeeping and financial affairs, but she had no complaints.
Elevated arterial blood pressure was documented on several occasions, but she
never took medication. She had no children and had a hysterectomy.
She was a well-groomed woman who was alert and friendly. General and
elemental neurological exams were normal.
39. Her speech was highly anomic and paraphasic, with a tendency to use vague
referents such as "things" and "stuff". She was able to provide her name, but
when asked about her current age, she said: "I don't know . . ., about 8 I think." She
incorrectly stated her birth month, but then became aware of this. Given three
choices, she was able to give the correct month. She was unable to give the year of
her birth, the current year, or the name of the current U.S. President.
On formal testing, she scored well below average in all cognitive domains. These
tests included the Wechsler Memory scale, the Wechsler Adult Intelligence Scale,
digit span and similarities subtests, the Boston Naming Test, the CERAD Word List
Memory Test, the CERAD Visuo-spatial Construction, the Cross Circle Tests, the
California Proverb Test, and the Graphomotor Alternation Test. She tended to
perseverate both verbal and motor responses.
The conclusion of the evaluation was that she met research criteria for "probable"
Alzheimer's disease, that she required complete supervision around the clock to
insure her safety, and that she would probably benefit from social stimulation
provided by a group living situation.
40. North American(FDA) and European Union(EMA) regulatory criteria for marketing
approval of putative symptomatic and disease-modifying therapeutic agents for AD
based on:
a demonstration of efficacy supported by improvements compared to placebo
treatment on cognitive function, activities of daily living (ADL)
and often evidence of overall clinical improvement or less overall decline accompanied
by adequate evidence of safety.
41. standardized protocols: mild to moderate AD is indexed by a Mini- Mental State
Examination (MMSE) score of 10–26 and
the Alzheimer’s Disease Assessment Scale— Cognitive Portion (ADAS-cog), the
Alzheimer’s Disease Cooperative Study Activities of Daily Living (ADCS-ADL) scale, or the
Disability Assessment for Dementia (DAD).
A clinician’s global assessment (known as a Clinician InterviewBased Impression of
Change with caregiver input [CIBICþ] or ADCS Clinical Global Impression of Change
[CGIC]) or the Clinical Dementia Rating (CDR), an interview-based overall dementia
severity assessment, are the conventional outcomes measures.
42. Acetylcholinesterase inhibitors (AChE-Is) are the first class of agents
specifically approved by the US Food and Drug Administration
(FDA)or the treatment of mild to moderate AD.
The responses to treatment with different AChE-Is have
overlapping confidence intervals (CI), and no individual
cholinesterase inhibitor has been shown to be superior to others in
terms of efficacy
Continuing benefit from use of AChE-Is has been shown in trials
lasting up to 2 years, among patients followed over that length of
time (AD2000 Collaborative Group 2004). In addition, patients with
severe AD—not previously treated with AChE-Is—respond to
treatment with AChE-Is, and donepezil is approved for treatment in
this advanced phase of the disease.
43. Memantine was used in Germany for the treatment of Parkinson’s
disease prior to its approval in the USA and globally for treatment of
AD.
Memantine is an NMDA receptor antagonist that replaces potassium
in the NMDA receptor channel to reduce entry of calcium into
neurons and avoid calcium-stimulated apoptotic cell death
cascades.
Clinical trials of memantine have been very similar in design to
those conducted with AChE-Is, but have involved patients with
moderate to severe AD, rather than mild to moderate AD.
Memantine is not approved by the FDA for patients with mild AD.
European regulatory authorities extended the range of approval for
use of memantine to patients with MMSE scores of 19 and below.
44.
45.
46. Cholinesterase inhibitors and memantine are potential therapies for the management of
many cognitive symptoms of AD, but these neurotransmitter-based approaches do not
address the underlying pathology of the illness, and ultimately fail to prevent its
progression.
Gastrointestinal side effects : Anorexia, nausea, vomiting, diarrhea, and weight loss
may occur and should be monitored in patients treated with these agents. In addition,
cholinergic influences may slow heart rate and bradycardia is a contraindication to use
of AChE-Is.
In cases where these drugs appear to be effective, patients and caregivers reported a
slowing in symptoms such as memory loss, reduced anxiety, improved mood and
restored confidence levels. Some patients will respond and others not to AChE-Is.
Once a patient stops taking a drug, their condition will deteriorate over a period of 4 to
6 weeks until they are at the same point as an individual who has not taken the drug.
47. Passive immunotherapy refers to the direct administration of anti-beta-amyloid
antibodies, obviating the need for patients to mount an antibody response. Passive
immunotherapy in the form of specifically designed monoclonal antibodies allows for
the precise targeting of beta-amyloid epitopes.
In contrast, active immunotherapy involves the administration of either full-length
betaamyloid peptides or peptide fragments to activate the patient’s immune system in
order to produce anti-betaamyloid antibodies.
AN1792, a synthetic beta-amyloid peptide, was the first active amyloid immunotherapy
tested in clinical trials. As compared with placebo treated patients, antibody responders
had a 25% lower decline in activities of daily living as assessed by the DAD. The trial was
stopped due to cases of meningoencephalitis.
Bapineuzumab is a humanized monoclonal antibody (passive) that targets the N-
terminal region of beta amyloid. Bapineuzumab/placebo differences in 11C-PiB
retention were statistically significant in all prespecified cortical regions (anterior and
posterior cingulate, frontal, temporal, parietal, and occipital cortex).
48.
49. Positron emission tomography (PET) carbon-11-labelled Pittsburgh compound B (11C-
PiB) images from patients treated with bapineuzumab and those given placebo. This
finding correlates to an approximately 25% reduction in cortical beta amyloid in
bapineuzumab-treated patients.
50. There is an urgent need for effective, safe, psychotropic agents for treatment of
behavioral disturbances in AD and other dementing disorders.
Behavioral disturbances are common in AD, including depression, agitation, irritability,
aberrant motor behaviors, and psychosis. There are no agents approved by the FDA
specifically for treatment of behavioral disturbances in AD.
Antipsychotics— both conventional and atypical—are associated with increased
mortality and some antipsychotics are associated with increased risk for cerebrovascular
accidents or stroke when administered to elderly patients with AD. The risk of death is
increased from 2.6% to 4.5% during an average of 10 weeks of therapy.
Several 1–12 week long clinical trials suggest that risperidone and possibly other atypical
antipsychotic agents in low doses are efficacious in reducing psychosis and agitation in
mainly nursing home patients with AD.
51. Strategies for use of antipsychotics in patients with AD involve avoiding their use in
patients with cardiovascular or pulmonary disease (the two most common causes of
death in mortality studies), using these agents only in patients for whom
nonpharmacologic interventions have failed and the behaviors are extreme.
Clinical trials have been largely negative in showing benefit for treatment of depression
in AD with antidepressant medications. Individual practitioners may use practice-based
evidence to guide their therapeutic decisions.
Anxiolytics and hypnotics are generally to be avoided in patients with AD as they may
increase confusion. Short term use of benzodiazepines such as lorazepam or
clonazepam may be useful in patients with episodes of agitation.
Greater cognitive impairment is by far the most consistent correlate of psychosis in late
onset Alzheimer’s disease. Also, Evidence of familial aggregation of psychosis in
Alzheimer’s disease suggests that this phenotype is under genetic control.
52.
53.
54. A. http://www.alz.org/documents_custom/2012_Facts_Figures_Fact_Sheet.pdf
B. http://www.alzinfo.org/07/about-alzheimers/non-genetic-risk-factors
C. http://www.nlm.nih.gov/medlineplus/ency/article/000760.htm
D. Paul S. Aisen, et. al.: “Symptomatic and Nonamyloid/Tau Based Pharmacologic Treatment for Alzheimer Disease.” Cold Spring Harb Perspect Med,
2012; 2:a006395
E. “Alzheimer’s Disease: Unraveling the Mystery.” U.S. Department of Health and Human Services, NIH Publication Number: 08-3782 September 2008.
F. Wierenga, C et. al.: “Use of Functional Magnetic Resonance Imaging in the Early Identification of Alzheimer’s Disease.” Neuropsychol Rev. 2007 June ;
17(2): 127–143. doi:10.1007/s11065-007-9025-y.
G. “Genetics of Late-Onset Alzheimer’s Disease: Update from the Alzgene Database and Analysis of Shared Pathways.” International Journal of
Alzheimer’s Disease Volume 2011, Article ID 832379, 14 pages, doi:10.4061/2011/832379.
H. Lobello K et. al.: “Targeting Beta Amyloid: A Clinical Review of Immunotherapeutic Approaches in Alzheimer’s Disease.” International Journal of
Alzheimer’s Disease Volume 2012, Article ID 628070, 14 pages, doi:10.1155/2012/628070.
I. Bateman RJ, et al.: “Autosomal-dominant Alzheimer’sdisease: a review and proposal for the prevention of Alzheimer’s disease.” Alzheimer’s
Research & Therapy 2011, 3:1.
J. Sweet R et. al.: “Assessment and familial aggregation of psychosis in Alzheimer’s disease from the National Institute on Aging Late Onset Alzheimer’s
Disease Family Study.” Brain 2010: 133; 1155–1162.
K. http://www.health.gov.bc.ca/pharmacare/adti/clinician/cholinesterase.html
L. http://youtu.be/VlD2xIuiMEU
M. http://www.med.harvard.edu/aanlib/home.html
Editor's Notes
Re: Video slides – make sure to enable when opening presentationMake sure there is internet connection to link to the video.
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dementia. (n.d.) Mosby's Medical Dictionary, 8th edition. (2009). Retrieved March 20 2012 from http://medical-dictionary.thefreedictionary.com/dementia Ref I 1, 2. Ref C 3-4.
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Ref AThis is a startling statistic emphatically declaring the need for intensive AD research and development.
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Ref NPET scan using blood flow as marker for perfusion in brain areas.
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Ref NPET scan using blood flow as marker for perfusion in brain areas.
Imagine being able to see deep inside the brain tissue of a living person. If you could do that, you could find out whether the AD process was happening many years before symptoms were evident. This knowledge could have a profound impact on improving early diagnosis, monitoring disease progression, and tracking response to treatment.Then read through bullets and then caption.Ref, text and image, E
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Ref BThis image tells the story of the destruction that is occuring within the heads of AD patients and underscores the need for further study.
It takes a second for the first frame to appear with the play button, so perhaps turn the prior slide slightly early then press play when introduction to video is complete.Ref L
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Ref IRead textAs a result of this last finding, further study may reveal the more severe atrophy will correlate with more severe clinical symptoms.
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Ref JRead textNote the Misidentifying people, Paranoia, and believing the dead are still alive were the most common psychotic symptoms. Hallucinations, auditory and visual, along with believing their house was not their home were the next most significant group. Only 7.7% thought the television was real and 5.2 could not recognize themselves.
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Ref D This slide shows the trade names for the 3 approved cholinesterase inhibitors trade names Donepezil, Rivastigmine, and Galantamine; that is, Aricept, Exelon and Razadyne respectively. Note Exelon is also indicated for treatment of Parkinson’s type dementia. Exelon has a patch form and Razadyne has an extended release version. Also note in the footnote that Tacrine (Cognex) is rarely used due to liver enzyme elevations.
Ref D Note the trade name, Namenda. This slide indicates Memantine is approved only for moderate to severe AD. Renal failure is a contraindication and dosage should be reduced by 50%.
Ref D 1-2 . Ref K 3-4. Read text. Only donepezil in approved in the US for use in severe AD. At some point, patients taking any of the other drugs would have to stop if their symptoms worsened causing further deterioration even if the treatment was helping.
Ref HImmunotherapeutic agents capable of reversing or preventing AD appear to offer the greatest promise for future treatment of AD.Read Text.While studies with AN1792 were discontinued due to the occurrence of meningoencephalitis, the trials paved the way for the many active immunotherapeutic clinical trials currently in progress
Ref H This just to show the other active immunotherapy AD trials that have begun out of the lessons learned from the AN1792 trial. Note there are three compounds in phase 2 status.
Ref HRead text Note in each of the top slides, the amount of red decreased from screening to week 78. However, in the bottom slides, the amount of red increases from screening to week 78 for each patient. These findings demonstrate the effectiveness of bapineuzumab in reducing the amount of cortical beta amyloid. The placebo subjects saw and increase in cortical beta amyloid. Unfortunately, these findings have not been correlated to a reduction in clinical symptoms or a slowing or reversing of AD progression.
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Ref JRead textAn important question then is in what way genetic factors might lead to psychosis in Alzheimer’s disease
Ref H Rosiglitazone, Statins, Estrogen, NSAIDs, B-vitamins, HGH/IGF-1, Lithium, Valproic Acid, while they may have certain benefits to AD structural or behavioral signs and symptoms, are not actively being pursued as a viable treatment for AD. Interestingly, Dimebon, a mitochondrial neuroprotectant, has a Phase III add-on trial in progress. Similarly, Insulin, to improve AD pathology and improve synaptic dysfunction has Phase II trials planned. Rosiglitazone made it to Phase III but is currently not being actively pursued.
Ref HNote that Resveratrol and NGF gene delivery are the only of these substances being pursued further according to this report as a treatment option for AD. A considerable drawback of NGF gene delivery is that is requires a neurosurgical procedure to administer. Axona and Souvenaid suffered negative trial results yet are marketed as medical food. Xaliproden and Idebenone are not actively sought for AD treatment. Vitamin E use is limited by Toxicity concerns. And, acetyl-L-carnitine as well as leuprolide received negative outcomes on clinical trials.
http://www.alz.org/documents_custom/2012_Facts_Figures_Fact_Sheet.pdfhttp://www.alzinfo.org/07/about-alzheimers/non-genetic-risk-factorshttp://www.nlm.nih.gov/medlineplus/ency/article/000760.htmPaul S. Aisen, et. al.: “Symptomatic and Nonamyloid/Tau Based Pharmacologic Treatment for Alzheimer Disease.” Cold Spring Harb Perspect Med, 2012; 2:a006395“Alzheimer’s Disease: Unraveling the Mystery.” U.S. Department of Health and Human Services, NIH Publication Number: 08-3782 September 2008.Wierenga, C et. al.: “Use of Functional Magnetic Resonance Imaging in the Early Identification of Alzheimer’s Disease.” Neuropsychol Rev. 2007 June ; 17(2): 127–143. doi:10.1007/s11065-007-9025-y.“Genetics of Late-Onset Alzheimer’s Disease: Update from the Alzgene Database and Analysis of Shared Pathways.” International Journal of Alzheimer’s Disease Volume 2011, Article ID 832379, 14 pages, doi:10.4061/2011/832379.Lobello K et. al.: “Targeting Beta Amyloid: A Clinical Review of Immunotherapeutic Approaches in Alzheimer’s Disease.” International Journal of Alzheimer’s Disease Volume 2012, Article ID 628070, 14 pages, doi:10.1155/2012/628070.Bateman RJ, et al.: “Autosomal-dominant Alzheimer’sdisease: a review and proposal for the prevention of Alzheimer’s disease.” Alzheimer’s Research & Therapy 2011, 3:1.Sweet R et. al.: “Assessment and familial aggregation of psychosis in Alzheimer’s disease from the National Institute on Aging Late Onset Alzheimer’s Disease Family Study.” Brain 2010: 133; 1155–1162.http://www.health.gov.bc.ca/pharmacare/adti/clinician/cholinesterase.htmlhttp://youtu.be/VlD2xIuiMEUhttp://www.med.harvard.edu/aanlib/home.html
Scott Zatzkis recently relocated to France with his family, where he continues to pursue his freelance career. Mr. Zatzkis enjoys delivering high-quality research, presentations, and reports, including creative and cutting-edge solutions, for his individual and corporate clientele.Mr. Zatzkis obtained his Bachelor of Arts degree in English from Vanderbilt University in Nashville, Tennessee. He also received his Juris Doctorate from Quinnipiac University Law School in Hamden, Connecticut. He practiced law for 12 years in Louisiana. During his professional career, Mr. Zatzkis drafted numerous legal documents and reports for presentation to clients, attorneys, judges and other groups. He strives to bring a creative edge to his freelance work that often was not appreciated in his legal work. Please feel free to contact him at szatzkis@att.net or visit his freelance work site on Elance.com at http://scott_zatzkis.elance.com