Carbon Dioxide Transport

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Transport of carbon dioxide H + ,[object Object],[object Object],[object Object],[object Object]

Transport of carbon dioxide ,[object Object]

Transport of carbon dioxide ,[object Object],CO 2 plasma

Transport of carbon dioxide ,[object Object],+ H 2 O H + + HCO 3 - plasma CO 2 enzyme

Transport of carbon dioxide ,[object Object],HCO 3 - plasma

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Formation of hydrogen carbonate ,[object Object],[object Object],[object Object]

Formation of hydrogen carbonate ,[object Object],[object Object],[object Object],[object Object]

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Bohr’s effect- The Bohr effect is a physiological phenomenon first described by Danish physiological Christian Bohr, stating that the “oxygen binding affinity of hemoglobin is inversely related to the concentration of carbon dioxide and hydrogen ion. #An increase in blood CO2 concentration which leads to decrease in blood pH will results in hemoglobin proteins releasing their oxygen load. #One of the factor that Bohr discovered was pH. He found that if the pH is lower than the normal, then hemoglobin does not bind oxygen. #And this effect of CO2 on oxygen dissociation curve is known as Bohr effect. Haldane effect- The Haldane effect is first discovered by John Scott Haldane. #The Haldane effect describe the phenomenon by which binding of oxygen to hemoglobin promotes the release of carbon dioxide. #Haldane effect is the mirror image of Bohr effect. #The decrease in carbon dioxide leads to increase in the pH, which result in hemoglobin picking up more oxygen. #This is a helpful biochemical feature which facilitates exchange of carbon dioxide for oxygen in the pulmonary and peripheral circulations.

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Supply of oxygen to tissues mainly involves two systems i.e. respiratory system and the cardiovascular system. Supply of oxygen to tissues depends upon Adequate PO2 in atmospheric air Adequate pulmonary ventilation Adequate gaseous exchange in the lungs Adequate uptake of oxygen by the blood Adequate blood flow to the tissues Adequate ability of the tissues to utilize oxygen Oxygen diffuses from the alveoli into the pulmonary capillary blood because the oxygen partial pressure (Po2) in the alveoli is greater than the Po2 in the pulmonary capillary blood. In the other tissues of the body, a higher Po2 in the capillary blood than in the tissues causes oxygen to diffuse into the surrounding cells. The Po2 of the gaseous oxygen in the alveolus averages 104 mm Hg, whereas the Po2 of the venous blood entering the pulmonary capillary at its arterial end averages only 40 mm Hg Therefore, the initial pressure difference that causes oxygen to diffuse into the pulmonary capillary is 104 – 40, or 64 mm Hg. About 98 percent of the blood that enters the left atrium from the lungs has just passed through the alveolar capillaries and has become oxygenated up to a Po2 of about 104 mm Hg. Another 2 per cent of the blood which supplies mainly the deep tissues of the lungs and is not exposed to lung air. This blood flow is called “shunt flow,” meaning that blood is shunted past the gas exchange areas One gram of Hb can bind 1.34 ml of Oxygen Normal level of Hb is 15 grams/dL Thus 15 grams of hemoglobin in 100 milliliters of blood can combine with a total of almost exactly 20 milliliters of oxygen if the hemoglobin is 100 per cent saturated This is usually expressed as 20 volumes per cent Hemoglobin is a conjugated protein consisting of heme and globin. The ferrous form can bind oxygen. Hemoglobin molecule consists of four subunits each consists of one heme and one polypeptide chain Each subunit can bind one molecule of Oxygen Oxygenation is a very rapid and reversible process and it can occur in 0.01 seconds When PO2 is high, oxygen binds with Hb to form Oxyhemoglbin When PO2 is low oxygen leaves Hb to form Deoxy Hb. Factors that shift the oxygen hemoglobin dissociation curve

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Neural control of respiration (like neural control of many other physiological functions, micturition, for example) is highly complex and not fully elucidated. Research is still going on to determine the centers in the brain and their complex interactions. There may be variations of opinion between different researchers depending on newer findings. Every effort has been made to keep this information as current and authoritative as possible, yet in a simple enough form for the student to understand and digest the information. Dr Sanjoy Sanyal, Professor and Course Director of Neuroscience and FCM-III Neurology in Caribbean created this PPTX after studying this complex topic for a very long time. Tags: Respiration, Breathing, Respiratory Centers, Brainstem, Apneustic Breathing, Biots Breathing, Cheyne-Stokes, Ataxic, Agonal, Kussmaul, Brainstem Reticular Nuclei, NTS, Locus Ceruleus, Fastigial, Raphe nucleus, Vagus, RTN nucleus, pFRG nucleus, Kolliker-Fuse, PBC nucleus, RVL nucleus "Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use." Educational Value: A very complex and poorly understood topic has been rendered in as simple a format and style as possible, so as to make it easily digestible to any Basic Science medical student and Medical Resident

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The control of respiration seems to be based on the following factors: a) An intrinsic rhythm of the respiratory neurones of the medulla oblongata. This rhythm is dependent upon oxygen supply to the neurones involved. It is regulated by both reflex and chemical mechanisms. b) The chemical regulation of respiration concerns the hydrogen ion content of the respiratory neurones which in turn is dependent upon the carbon dioxide tension of the blood and the rate of flow of blood through the medulla. Variations in blood oxygen tension under normal conditions are not thought to be concerned with direct regulating effects on the respiratory neurones. The control of respiration seems to be based on the following factors: a) An intrinsic rhythm of the respiratory neurones of the medulla oblongata. This rhythm is dependent upon oxygen supply to the neurones involved. It is regulated by both reflex and chemical mechanisms. b) The chemical regulation of respiration concerns the hydrogen ion content of the respiratory neurones which in turn is dependent upon the carbon dioxide tension of the blood and the rate of flow of blood through the medulla. Variations in blood oxygen tension under normal conditions are not thought to be concerned with direct regulating effects on the respiratory neurones. The Chemical Control of Respiration As already pointed out the role of anoxemia is concerned with a direct depressing influence of oxygen lack on the respiratory cells of the medulla, and an opposing excitatory effect upon chemoreceptors in the carotid body whose stimulation results in reflex augmentation of respiration. The respiratory neurones of the medulla, however, are extremely sensitive to variations in the CO2 tension of the blood and somewhat less so to any other acids. In both cases the stimulatory effect concerns

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At the end of this session, the student should be able to: Describe the forms in which carbon dioxide is transported in the blood. Describe the importance of the chloride shift in the transport of carbon dioxide by blood and the changes caused by this shift. Describe carbon dioxide dissociation curves and how it is affected by oxygen binding to hemoglobin. Discuss respiratory acidosis and alkalosis, and their compensatory role (revise). Define respiratory exchange ratio and mention the significance of its estimation. GUYTON & HALL Textbook of Medical Physiology, 12th edition, page: 502-504.

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The major mechanism of CO 2 transport in the blood is by bound to CO 2 binding sites of hemoglobin dissolved in blood plasma bound to serum albumin bound to the O 2 binding site of hemoglobin as HCO - (bicarbonate ion) Receptors on cardiac muscle that decrease heart rate are ionotropic muscarinic adrenergic dopaminergic nicotinic Blood plasma is composed of all of the following EXCEPT dissolved gases water molecules electrolytes erythrocytes proteins As blood flows through a systemic capillary there is additional unloading of O 2 from hemoglobin because metabolites including CO 2 and H + shift the oxyhemoglobin curve to the left there is additional loading of O 2 onto hemoglobin because metabolites including CO 2 and H + shift the oxyhemoglobin curve to the right there is additional unloading of O 2 from hemoglobin because metabolites including CO 2 and H + shift the oxyhemoglobin curve to the right there is additional loading of O 2 onto hemoglobin because metabolites including CO 2 and H + shift the oxyhemoglobin curve to the left .

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Once the oxygen diffuses across the alveoli, it enters the bloodstream and is transported to the tissues where it is unloaded, and carbon dioxide diffuses out of the blood and into the alveoli to be expelled from the body. Although gas exchange is a continuous process, the oxygen and carbon dioxide are transported by different mechanisms. What You’ll Learn to Do Describe how oxygen is bound to hemoglobin and transported to body tissues Explain how carbon dioxide is transported from body tissues to the lungs

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