This document summarizes the misconceptions around opioid use and addiction. It discusses how opioids work in the brain to produce both analgesia and euphoria through activation of mu-opioid receptors. Repeated use leads to tolerance and physical dependence, but addiction only occurs in a small percentage of patients and involves distinct molecular mechanisms. Common misconceptions include equating addiction, tolerance and physical dependence. The document advocates for strategies to minimize risks of diversion and abuse through abuse-deterrent formulations.
This document discusses various types and causes of constipation and treatments. It describes laxatives and purgatives that have mild or strong actions to soften stool or induce evacuation. Bulk forming laxatives work by absorbing water to increase stool volume while osmotic laxatives retain water in the intestines. Stimulant laxatives like bisacodyl work by irritating the intestines to increase secretion. Laxatives are used to treat short-term constipation, evacuate the bowels before procedures, remove toxins, and help with worm treatments. The main actions and indications of various laxatives are outlined.
The document discusses organophosphate poisoning, noting that organophosphates inhibit acetylcholinesterase leading to overstimulation of the nervous system. Treatment involves administering atropine to block muscarinic effects along with pralidoxime (2-PAM) to reactivate acetylcholinesterase. Additional treatments discussed are benzodiazepines which can be used to treat agitated delirium, seizures, and reduce respiratory failure caused by organophosphate poisoning.
Using EventStorming to drill into domain modelling complexity: from the big picture into the design of aggregates, processes and read models. A different approach to enterprise software modelling.
Blood products are components separated from whole blood that are used for transfusion. They include red cell concentrate, platelet concentrate, fresh frozen plasma, cryoprecipitate, and coagulation factor concentrates. Blood substitutes aim to mimic the oxygen carrying capacity of blood, and include volume expanders like crystalloids and colloids, as well as synthetic oxygen carriers under clinical trials. Whole blood and its components are prepared by centrifuging donated blood to separate out red cells, platelets, and plasma, which are stored and transfused according to their indications to treat conditions like anemia, bleeding, and thrombocytopenia.
This document summarizes the misconceptions around opioid use and addiction. It discusses how opioids work in the brain to produce both analgesia and euphoria through activation of mu-opioid receptors. Repeated use leads to tolerance and physical dependence, but addiction only occurs in a small percentage of patients and involves distinct molecular mechanisms. Common misconceptions include equating addiction, tolerance and physical dependence. The document advocates for strategies to minimize risks of diversion and abuse through abuse-deterrent formulations.
This document discusses various types and causes of constipation and treatments. It describes laxatives and purgatives that have mild or strong actions to soften stool or induce evacuation. Bulk forming laxatives work by absorbing water to increase stool volume while osmotic laxatives retain water in the intestines. Stimulant laxatives like bisacodyl work by irritating the intestines to increase secretion. Laxatives are used to treat short-term constipation, evacuate the bowels before procedures, remove toxins, and help with worm treatments. The main actions and indications of various laxatives are outlined.
The document discusses organophosphate poisoning, noting that organophosphates inhibit acetylcholinesterase leading to overstimulation of the nervous system. Treatment involves administering atropine to block muscarinic effects along with pralidoxime (2-PAM) to reactivate acetylcholinesterase. Additional treatments discussed are benzodiazepines which can be used to treat agitated delirium, seizures, and reduce respiratory failure caused by organophosphate poisoning.
Using EventStorming to drill into domain modelling complexity: from the big picture into the design of aggregates, processes and read models. A different approach to enterprise software modelling.
Blood products are components separated from whole blood that are used for transfusion. They include red cell concentrate, platelet concentrate, fresh frozen plasma, cryoprecipitate, and coagulation factor concentrates. Blood substitutes aim to mimic the oxygen carrying capacity of blood, and include volume expanders like crystalloids and colloids, as well as synthetic oxygen carriers under clinical trials. Whole blood and its components are prepared by centrifuging donated blood to separate out red cells, platelets, and plasma, which are stored and transfused according to their indications to treat conditions like anemia, bleeding, and thrombocytopenia.
2013 040. Est-ce qu’une prothèse de rotule “custom” limite la flexion dans le...jofdf
040. Est-ce qu’une prothèse de rotule “custom” limite la flexion dans les trochlées dysplasiques? - Does a custom Patellofemoral Replacement limit flexion in a dysplastic trochlea?
2013 040. Est-ce qu’une prothèse de rotule “custom” limite la flexion dans le...jofdf
040. Est-ce qu’une prothèse de rotule “custom” limite la flexion dans les trochlées dysplasiques? - Does a custom Patellofemoral Replacement limit flexion in a dysplastic trochlea?