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Heart Rhythm
This study examined the effects of progressive weight gain on the development of atrial fibrillation (AF) in sheep. Sheep were fed a high calorie diet to induce obesity over 8 months while controls maintained normal weight. Cardiac imaging, electrophysiological testing, histology, and molecular analysis were performed at baseline, 4 months, and 8 months. The results showed that increasing weight was associated with larger left atrial size, more atrial fibrosis, inflammation and lipid deposits. Weight gain also reduced conduction velocity, increased conduction heterogeneity and AF inducibility. Molecular markers of fibrosis increased with greater adiposity. Therefore, progressive obesity leads to structural and electrical remodeling in the atria that promotes the development of AF.
Svt maneuvers hany abed
This document outlines techniques for differentiating supraventricular tachycardias (SVTs). It discusses features of SVT induction and baseline tachycardia characteristics, as well as diagnostic maneuvers that can be performed during tachycardia and after termination in sinus rhythm. These include the effects of atrial and ventricular extrastimulation or pacing on SVT cycle length, VA intervals, and atrial activation sequences to help identify the mechanism as atrial tachycardia, atrioventricular nodal reentrant tachycardia, or orthodromic reentrant tachycardia using an accessory atrioventricular connection. The document provides detailed descriptions and examples of applying these diagnostic tests.
Abed_et_al-2013-Obesity_Reviews
This document summarizes the relationship between obesity and atrial fibrillation (AF). It discusses how obesity is linked to an increased risk of developing AF through both direct and indirect mechanisms. Obesity is associated with cardiovascular risk factors like hypertension, sleep apnea, and insulin resistance, which can promote AF through effects on the heart like fibrosis and electrophysiological dysfunction. The rising rates of obesity are thought to be a major contributing factor to the increasing prevalence of AF worldwide.
JACC
1) The study examined the relationship between pericardial fat volumes measured by cardiac MRI and atrial fibrillation (AF) in 110 patients undergoing AF ablation and 20 control patients without AF.
2) The results showed that higher pericardial fat volumes were significantly associated with the presence of AF, longer duration of AF, and greater AF symptom burden. Higher fat volumes also predicted recurrence of AF after ablation.
3) Pericardial fat volumes were also correlated with larger left atrial volumes. These associations between pericardial fat and AF severity/outcomes remained even after adjusting for body weight and other measures of adiposity.
JAMA
This randomized clinical trial studied 150 overweight or obese patients with atrial fibrillation who were assigned to either an intensive weight loss and risk factor management program (intervention group) or general lifestyle advice (control group). The intervention group had significantly greater reductions in weight, atrial fibrillation symptom burden and severity scores, number of atrial fibrillation episodes, cumulative duration of atrial fibrillation, and improvements in cardiac structure compared to the control group. The findings support managing weight and risk factors to reduce atrial fibrillation symptoms and burden.
Recommandé
Heart Rhythm
This study examined the effects of progressive weight gain on the development of atrial fibrillation (AF) in sheep. Sheep were fed a high calorie diet to induce obesity over 8 months while controls maintained normal weight. Cardiac imaging, electrophysiological testing, histology, and molecular analysis were performed at baseline, 4 months, and 8 months. The results showed that increasing weight was associated with larger left atrial size, more atrial fibrosis, inflammation and lipid deposits. Weight gain also reduced conduction velocity, increased conduction heterogeneity and AF inducibility. Molecular markers of fibrosis increased with greater adiposity. Therefore, progressive obesity leads to structural and electrical remodeling in the atria that promotes the development of AF.
Svt maneuvers hany abed
This document outlines techniques for differentiating supraventricular tachycardias (SVTs). It discusses features of SVT induction and baseline tachycardia characteristics, as well as diagnostic maneuvers that can be performed during tachycardia and after termination in sinus rhythm. These include the effects of atrial and ventricular extrastimulation or pacing on SVT cycle length, VA intervals, and atrial activation sequences to help identify the mechanism as atrial tachycardia, atrioventricular nodal reentrant tachycardia, or orthodromic reentrant tachycardia using an accessory atrioventricular connection. The document provides detailed descriptions and examples of applying these diagnostic tests.
Abed_et_al-2013-Obesity_Reviews
This document summarizes the relationship between obesity and atrial fibrillation (AF). It discusses how obesity is linked to an increased risk of developing AF through both direct and indirect mechanisms. Obesity is associated with cardiovascular risk factors like hypertension, sleep apnea, and insulin resistance, which can promote AF through effects on the heart like fibrosis and electrophysiological dysfunction. The rising rates of obesity are thought to be a major contributing factor to the increasing prevalence of AF worldwide.
JACC
1) The study examined the relationship between pericardial fat volumes measured by cardiac MRI and atrial fibrillation (AF) in 110 patients undergoing AF ablation and 20 control patients without AF.
2) The results showed that higher pericardial fat volumes were significantly associated with the presence of AF, longer duration of AF, and greater AF symptom burden. Higher fat volumes also predicted recurrence of AF after ablation.
3) Pericardial fat volumes were also correlated with larger left atrial volumes. These associations between pericardial fat and AF severity/outcomes remained even after adjusting for body weight and other measures of adiposity.
JAMA
This randomized clinical trial studied 150 overweight or obese patients with atrial fibrillation who were assigned to either an intensive weight loss and risk factor management program (intervention group) or general lifestyle advice (control group). The intervention group had significantly greater reductions in weight, atrial fibrillation symptom burden and severity scores, number of atrial fibrillation episodes, cumulative duration of atrial fibrillation, and improvements in cardiac structure compared to the control group. The findings support managing weight and risk factors to reduce atrial fibrillation symptoms and burden.
ACC
This study evaluated the effects of a structured weight management program versus lifestyle counseling on pericardial fat volume, atrial fibrillation severity, and cardiac structure in overweight and obese patients with atrial fibrillation. Patients in the weight management program lost significantly more weight and had greater reductions in pericardial fat volume, left and right atrial volumes, and myocardial mass compared to the lifestyle counseling group. Pericardial fat volume was the strongest predictor of improvement in atrial fibrillation severity. Weight reduction was associated with favorable changes in pericardial fat volume, atrial size, and myocardial mass.
Impact-of-weight-reduction-on-pericardial-adipose-tissue-and-cardiac-structur...
1) The study evaluated the effects of a structured weight loss program versus general lifestyle advice on pericardial adipose tissue and cardiac structure in overweight/obese patients with atrial fibrillation using cardiac MRI imaging.
2) At 12 months, the weight loss intervention group achieved greater reductions in weight, waist circumference, pericardial adipose tissue, left atrial volume, and myocardial mass compared to the control group.
3) The results suggest that weight reduction through a structured program leads to favorable remodeling of the heart and reduction of pericardial fat, which may help explain reductions in atrial fibrillation burden from weight loss.
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Plus de Hany Abed
ACC
This study evaluated the effects of a structured weight management program versus lifestyle counseling on pericardial fat volume, atrial fibrillation severity, and cardiac structure in overweight and obese patients with atrial fibrillation. Patients in the weight management program lost significantly more weight and had greater reductions in pericardial fat volume, left and right atrial volumes, and myocardial mass compared to the lifestyle counseling group. Pericardial fat volume was the strongest predictor of improvement in atrial fibrillation severity. Weight reduction was associated with favorable changes in pericardial fat volume, atrial size, and myocardial mass.
Impact-of-weight-reduction-on-pericardial-adipose-tissue-and-cardiac-structur...
1) The study evaluated the effects of a structured weight loss program versus general lifestyle advice on pericardial adipose tissue and cardiac structure in overweight/obese patients with atrial fibrillation using cardiac MRI imaging.
2) At 12 months, the weight loss intervention group achieved greater reductions in weight, waist circumference, pericardial adipose tissue, left atrial volume, and myocardial mass compared to the control group.
3) The results suggest that weight reduction through a structured program leads to favorable remodeling of the heart and reduction of pericardial fat, which may help explain reductions in atrial fibrillation burden from weight loss.
Plus de Hany Abed (6)
Impact-of-weight-reduction-on-pericardial-adipose-tissue-and-cardiac-structur...
Impact-of-weight-reduction-on-pericardial-adipose-tissue-and-cardiac-structur...