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FENTORA Oncology Speaker
     Identification

   Update and Recommendations
FENTORA Oncology Speaker Identification
              Methodology
                   TIRF REMS-Enrolled List
                          N = 7,786
                                 Filtered for ONCOLOGY

                       REMS-Enrolled
                        Oncologists
                         n = 1,647

   EVALUATION 1                                   EVALUATION 2
ROO Rx and/or
Teva Interaction                               COE Geography
                        EVALUATION 3

                     Recommended
                         Targets
EVALUATION 2


COE Geography
                                                                                                                                                         Brigham and Women's Hospital
                                                                                                                                                         Boston, MA
              Swedish Medical Center
              Seattle, WA
                                                                                                                                                         Dana-Farber Cancer Institute
                                                                                                                                                         Boston, MA

                                                                                                                                                         Massachusetts General Hospital
                                                                                                                                                         Boston, MA



                                                                                                              Memorial Sloane-Kettering Center
                                                                                                              New York City, NY
                                                                                                                                                         Yale-New Haven Hospital
                                                                                                                                                         New Haven, CT
                                       University of Utah Health Center
                                       Salt Lake City, UT
                                                                                                                   Cleveland Clinic
   Kaiser Permanente
                                                                                                                   Cleveland, OH
   Oakland, CA
                                                                          Indiana University Medical Center
                                                                          Indianapolis, IN

         City of Hope,
         Duarte, CA

             University of California, San Diego
             San Diego, CA




                                                                          MD Anderson Cancer Center
                                                                          Houston, TX
                                                                                                                                 Moffitt Cancer Center
                                                                                                                                 Tampa, FL
EVALUATION 2


COE Geography                                                                                                                   1 Oncologist

                                                                                                                                                            Brigham and Women's Hospital
                                                                                                                                                            Boston, MA
              Swedish Medical Center
              Seattle, WA
                                                                                                                                                            Dana-Farber Cancer Institute
                                                                                                                 1 Oncologist                               Boston, MA
        7 Oncologists                                                                                                                                       Massachusetts General Hospital
                                                                                                                                                            Boston, MA



                                                                                                                 Memorial Sloane-Kettering Center
                                 1 Oncologist                                                                    New York City, NY
                                                                                                                                                            Yale-New Haven Hospital
                                                                                  2 Oncologists                                                             New Haven, CT
                                       University of Utah Health Center
                                       Salt Lake City, UT
                                                                                                                      Cleveland Clinic
   Kaiser Permanente
                                                                                                                      Cleveland, OH
   Oakland, CA
     6 Oncologists                                                                                                                                    1 Oncologist
                                                                             Indiana University Medical Center
                                                                             Indianapolis, IN
                                                                                                                   2 Oncologists

         City of Hope
         Duarte, CA

             University of California, San Diego
             San Diego, CA




                                                                          28 Oncologists

                                                                            MD Anderson Cancer Center
                                                                            Houston, TX
                                                                                                                                    Moffitt Cancer Center
                                                                                                                                    Tampa, FL
EVALUATION 2


COE Geography                                                                                                                    4 Oncologists

                                                                                                                                                             Brigham and Women's Hospital
                                                                                                                                                             Boston, MA
               Swedish Medical Center
               Seattle, WA
                                                                                                                                                             Dana-Farber Cancer Institute
                                                                                                                  72 Oncologists                             Boston, MA
         7 Oncologists                                                                                                                                       Massachusetts General Hospital
                                                                                                                                                             Boston, MA



                                                                                                                  Memorial Sloane-Kettering Center
                                  11 Oncologists                                                                  New York City, NY
 2 Oncologists                                                                                                                                               Yale-New Haven Hospital
                                                                                   27 Oncologists                                                            New Haven, CT
                                        University of Utah Health Center
                                        Salt Lake City, UT
                                                                                                                       Cleveland Clinic
    Kaiser Permanente
                                                                                                                       Cleveland, OH
    Oakland, CA
      60 Oncologists                                                                                                                                   26 Oncologists
                                                                              Indiana University Medical Center
                                                                              Indianapolis, IN
                                                                                                                    27 Oncologists

          City of Hope,
          Duarte, CA

              University of California, San Diego
              San Diego, CA




                                                                           31 Oncologists

                                                                             MD Anderson Cancer Center
                                                                             Houston, TX
                                                                                                                                     Moffitt Cancer Center
                                                                                                                                     Tampa, FL


                                                                                                                                23 Oncologists
EVALUATION 2


COE Geography
                                                                                                              1 Oncologist
                                                                                                              Albany Area

                                                 1 Oncologist                            12 Oncologists
                                                 Minneapolis, MN Area                    New York City/Northern NJ Area         3 Oncologists
                                                                                                                                Boston Area
                                                                                                9 Oncologists
                                          2 Oncologists                     7 Oncologists
                                                                                                Pittsburgh Area
                                          Rochester, MN Area                Chicago Area

                                                                                             4 Oncologists
                                                                                             Ann Arbor Area
                                               2 Oncologists
                                               Madison, WI Area

                                                      2 Oncologists                                                                      16 Oncologists
                                                      Columbia, MO Area                                                                  Phila/Lehigh Valley Area

    10 Oncologists
    Los Angeles Area
                                                                                                                                        7 Oncologists
                                                                   2 Oncologists                                                        Baltimore/DC Area
                                                                   St. Louis, MO Area
                                              1 Oncologist                                                                                2 Oncologists
                                              Lubbock, TX Area                                                                            Chapel Hill, NC Area

                                                                        2 Oncologists                                                   2 Oncologists
                                                                        Nashville, TN Area                                              Charleston, SC Area

                       3 Oncologists
                                                                                                                                3 Oncologists
                       Phoenix, AZ Area
                                                                                                                                Atlanta Area

                                                                                                                                           2 Oncologists
                                                                                                                                           Northern Florida Area
                                                                  1 Oncologist
                                                                  Houston, TX Area


                                                                                                                          5 Oncologists
                                                                                                                          Miami/Southern Florida Area
EVALUATION 3          TIRF REMS-Enrolled List
Recommended                    N = 7,786
    Targets

                            REMS-Enrolled
                             Oncologists
                              n = 1,647


             REMS + 1                       COE Geography
               460                               438

  REMS Oncologists   REMS + 1     Top 14 COE      50 Miles   Next 86
                        460           49            290        99
BOTH LISTS              128            8            88         32

                        RECOMMENDED
                            128
Evaluation and Selection of
      Oncology HCPs
EVALUATION 4

  Qualitative
Research of 128

 • Determine HCPs with a clear interest in cancer
   pain management
    – Hit on 4 lists in previous evaluation
    – Published in cancer pain
    – Society involvement
    – Listed as clinical interest on bio


                 RECOMMENDED
                      24
EVALUATION 5

    Additional
Qualitative Research

  • Identify additional oncology HCPs with a focus
    on pain management
     – Published in cancer pain
     – Society involvement
     – Listed as clinical interest on bio
     – MSL recommendations
     – Author on pain guidelines


                    RECOMMENDED
                         21
Duke Cancer Institute
Dana-Farber Cancer Institute
Boston Baskin Cancer Foundation
Memorial Sloan-Kettering Cancer Center
MD Anderson Cancer Center
Vanderbilt-Ingram Cancer Center
Mayo Clinic
Cleveland Clinic
Mayo Clinic
Duke Divinity School, Duke University, Duke Institute
John Hopkins
Texas Oncology
 Fox Chase Cancer Center
 Center for Pain and Supportive Care
 Epic Care
 Emory Winship Cancer Institute
 University of Michigan, Comprehensive Cancer Center
 Universtiry of Washington
 Southwest Hematology Oncology
 Dartmouth-Hitchcock Norris Cotton Cancer Center
 Fox Chase Cancer Center




                                                        • 12 oncologists
                                                        • 9 NPs/PAs
• 12 oncologists
• 9 NPs/PAs
24 HCPS FROM
    REMS+1 LIST



 21 ADDITIONAL HCPS
 BASED ON RESEARCH

                      79 Oncology HCPs
27 RECOMMENDATIONS
    FROM SPEAKER      • 63 oncologists
                      • 16 NPs/PAs
 TRAINING ATTENDEES



7 RECOMMENDATIONS
   FROM THE NP/PA
 TIRF-ENROLLED LIST

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Kol recommendations sr

  • 1. FENTORA Oncology Speaker Identification Update and Recommendations
  • 2. FENTORA Oncology Speaker Identification Methodology TIRF REMS-Enrolled List N = 7,786 Filtered for ONCOLOGY REMS-Enrolled Oncologists n = 1,647 EVALUATION 1 EVALUATION 2 ROO Rx and/or Teva Interaction COE Geography EVALUATION 3 Recommended Targets
  • 3. EVALUATION 2 COE Geography Brigham and Women's Hospital Boston, MA Swedish Medical Center Seattle, WA Dana-Farber Cancer Institute Boston, MA Massachusetts General Hospital Boston, MA Memorial Sloane-Kettering Center New York City, NY Yale-New Haven Hospital New Haven, CT University of Utah Health Center Salt Lake City, UT Cleveland Clinic Kaiser Permanente Cleveland, OH Oakland, CA Indiana University Medical Center Indianapolis, IN City of Hope, Duarte, CA University of California, San Diego San Diego, CA MD Anderson Cancer Center Houston, TX Moffitt Cancer Center Tampa, FL
  • 4. EVALUATION 2 COE Geography 1 Oncologist Brigham and Women's Hospital Boston, MA Swedish Medical Center Seattle, WA Dana-Farber Cancer Institute 1 Oncologist Boston, MA 7 Oncologists Massachusetts General Hospital Boston, MA Memorial Sloane-Kettering Center 1 Oncologist New York City, NY Yale-New Haven Hospital 2 Oncologists New Haven, CT University of Utah Health Center Salt Lake City, UT Cleveland Clinic Kaiser Permanente Cleveland, OH Oakland, CA 6 Oncologists 1 Oncologist Indiana University Medical Center Indianapolis, IN 2 Oncologists City of Hope Duarte, CA University of California, San Diego San Diego, CA 28 Oncologists MD Anderson Cancer Center Houston, TX Moffitt Cancer Center Tampa, FL
  • 5. EVALUATION 2 COE Geography 4 Oncologists Brigham and Women's Hospital Boston, MA Swedish Medical Center Seattle, WA Dana-Farber Cancer Institute 72 Oncologists Boston, MA 7 Oncologists Massachusetts General Hospital Boston, MA Memorial Sloane-Kettering Center 11 Oncologists New York City, NY 2 Oncologists Yale-New Haven Hospital 27 Oncologists New Haven, CT University of Utah Health Center Salt Lake City, UT Cleveland Clinic Kaiser Permanente Cleveland, OH Oakland, CA 60 Oncologists 26 Oncologists Indiana University Medical Center Indianapolis, IN 27 Oncologists City of Hope, Duarte, CA University of California, San Diego San Diego, CA 31 Oncologists MD Anderson Cancer Center Houston, TX Moffitt Cancer Center Tampa, FL 23 Oncologists
  • 6. EVALUATION 2 COE Geography 1 Oncologist Albany Area 1 Oncologist 12 Oncologists Minneapolis, MN Area New York City/Northern NJ Area 3 Oncologists Boston Area 9 Oncologists 2 Oncologists 7 Oncologists Pittsburgh Area Rochester, MN Area Chicago Area 4 Oncologists Ann Arbor Area 2 Oncologists Madison, WI Area 2 Oncologists 16 Oncologists Columbia, MO Area Phila/Lehigh Valley Area 10 Oncologists Los Angeles Area 7 Oncologists 2 Oncologists Baltimore/DC Area St. Louis, MO Area 1 Oncologist 2 Oncologists Lubbock, TX Area Chapel Hill, NC Area 2 Oncologists 2 Oncologists Nashville, TN Area Charleston, SC Area 3 Oncologists 3 Oncologists Phoenix, AZ Area Atlanta Area 2 Oncologists Northern Florida Area 1 Oncologist Houston, TX Area 5 Oncologists Miami/Southern Florida Area
  • 7. EVALUATION 3 TIRF REMS-Enrolled List Recommended N = 7,786 Targets REMS-Enrolled Oncologists n = 1,647 REMS + 1 COE Geography 460 438 REMS Oncologists REMS + 1 Top 14 COE 50 Miles Next 86 460 49 290 99 BOTH LISTS 128 8 88 32 RECOMMENDED 128
  • 8. Evaluation and Selection of Oncology HCPs
  • 9. EVALUATION 4 Qualitative Research of 128 • Determine HCPs with a clear interest in cancer pain management – Hit on 4 lists in previous evaluation – Published in cancer pain – Society involvement – Listed as clinical interest on bio RECOMMENDED 24
  • 10. EVALUATION 5 Additional Qualitative Research • Identify additional oncology HCPs with a focus on pain management – Published in cancer pain – Society involvement – Listed as clinical interest on bio – MSL recommendations – Author on pain guidelines RECOMMENDED 21
  • 11. Duke Cancer Institute Dana-Farber Cancer Institute Boston Baskin Cancer Foundation Memorial Sloan-Kettering Cancer Center MD Anderson Cancer Center Vanderbilt-Ingram Cancer Center Mayo Clinic Cleveland Clinic Mayo Clinic Duke Divinity School, Duke University, Duke Institute John Hopkins Texas Oncology Fox Chase Cancer Center Center for Pain and Supportive Care Epic Care Emory Winship Cancer Institute University of Michigan, Comprehensive Cancer Center Universtiry of Washington Southwest Hematology Oncology Dartmouth-Hitchcock Norris Cotton Cancer Center Fox Chase Cancer Center • 12 oncologists • 9 NPs/PAs
  • 13. 24 HCPS FROM REMS+1 LIST 21 ADDITIONAL HCPS BASED ON RESEARCH 79 Oncology HCPs 27 RECOMMENDATIONS FROM SPEAKER • 63 oncologists • 16 NPs/PAs TRAINING ATTENDEES 7 RECOMMENDATIONS FROM THE NP/PA TIRF-ENROLLED LIST