Surbhi Narang

intraventricular drug infusion intracerebral impl vitamins and hormones. the more lipophilic substan nucleosides purine bases amines acidic amino acids basic amino acid neutral amino acids monocarboxylic acid and effect on all of the above by the existing  pa affinity for carrier mechanisms hydrogen bonding potential (i.e. charge) affinity for efflux mechanisms (i.e. p-glycoprotei cellular enzyme stability and cellular sequestrati ionization (nonionized form penetrates bbb) lipoph conformation flexibility constitute the bbb.  rate-limiting factor in deter together with perivascular elements such as  astro brain targeted drug delivery system prepared by : concept of optimization optimisation in formulatio similarity factor (f2) ( 16). ● model independent methods [difference facto etc.) (15 weibull model baker-lonsdale model hixson crowell korsmeyer-peppas model higuchi first order 14). ● model dependent methods (zero order multivariate approach [manova: multivariate analys repeated measures design ● statistical methods (exploratory data analysis m nernst and brunner film theory noyes-whitney rule kinetic modeling on drug release from controlled d laser desorption protein analysis atmospheric pressure photoionization electrospray ionization mass spectroscopy desorption ionization techniques fab maldi apci appi esi diazonium salts chemical derivatisation ultra voilet spectroscopy uv chemical derivatisation insulin delivery system rate controlled drug delivery system triggering agent feedback regulated drug delivery system