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Skeletal
Physiology
Gatlin Group B8
Fibrous Joint Structure
These types of joints are held together by
fibrous connective tissue, no joint cavity is
present. Either slightly mobile or immobile.
Synovial Joint Structure
Made up of synovial fluid, freely movable and
characterize most joints.
Subtypes-
Hyaline Cartilage- Covers the end of the bone
Synovial Membrane- Surrounds synovial cavity.
Fibrous capsule- Made up of ligaments ( dense,
irregular connective tissue)
Articulate capsule- Both synovial and fibrous
membrane.
Types Of Movement
SYNOVIAL JOINTS- All are freely movable
(diarthrosis)
Gliding- Two sliding surfaces
Hinge- Concave surface with convex surface,
diathrosis
Pivot- Rounded end fits into ring
Condyloid- oval condyle with oval cavity
Saddle- each surface is concave or convex
Ball&Socket- Ball shaped head, and cup
shaped pocket
Joint Types Pictures
Synovial   Fibrous   Cartilaginous
The Four Types of Bones
●   Long Bones
●   Short Bones
●   Flat Bones
●   Irregular Bones
Long Bones
These bones typically have an elongated shaft and two
expanded ends one on either side of the shaft. The shaft is
known as diaphysis and the ends are called epiphyses.
Normally the epiphyses are smooth and articular. The shaft
has a central medullary cavity where lies the bone marrow.

Examples include the humerus, femur, radius, ulna, tibia
and fibula
Short Bones
These bones are short in posture and can
be of any shape. Most of them are named
according to their shape.

Examples of this class of bones include
cuboid, cuneiform, scaphoid, trapezoid
etc. In fact all the carpal and tarsal bones
are included in this category.
Flat Bones
These bones are flat in appearance and
have two prominent surfaces. They
resemble shallow plates and form
boundaries of certain body cavities.

Examples include scapula, ribs, sternum
etc.
Irregular Bones
The shape of these bones is completely
irregular and they do not fit into any
category of shape.

Examples of this type of bones are
vertebrae, hip bone and bones in the
base of skull.
Major Structures of a Long
Bone
●   The diaphysis, or shaft, is the long tubular portion of long bones. It is
    composed of compact bone tissue.
●   The epiphysis (plural, epiphyses) is the expanded end of a long bone. It
    is in the epiphyses where red blood cells are formed.
●   The metaphysis is the area where the diaphysis meets the epiphysis. It
    includes the epiphyseal line, a remnant of cartilage from growing bones.
●   The medullary cavity, or marrow cavity, is the open area within the
    diaphysis. The adipose tissue inside the cavity stores lipids and forms the
    yellow marrow.
●   Articular cartilage covers the epiphysis where joints occur.
●   The periosteum is the membrane covering the outside of the diaphysis
    (and epiphyses where articular cartilage is absent). It contains
    osteoblasts (bone-forming cells), osteoclasts (bone-destroying cells),
    nerve fibers, and blood and lymphatic vessels. Ligaments and tendons
    attach to the periosteum.
●   The endosteum is the membrane that lines the marrow cavity.
The Typical Long Bone
Bone as a Tissue
There are two different kinds of bone tissue: Compact and Spongy bone.
Compact bone
 ● Is made up of concentric rings of matrix that surround central canals which
    contain blood vessels.
 ● Embedded in this bone tissue are small cave-like spaces called lacunae,
    which are connected to each other through small tunnels called canaliculi.
 ● The lacunae contain osteocytes cells. As just discussed, osteocytes help
    maintain healthy bone tissue and are involved in the bone remodeling
    process that will be outlined later in this lesson.
Spongy bone
 ● Looks like an irregular latticework (or sponge) with lots of spaces
    throughout.
 ● These spaces are filled with red bone marrow which is the site of
    hematopoiesis or formation of blood cells.
The Haversian System
A Haversian System consists of many cylinder-shaped
structural units. There are four types of structures that make up
each Haversian system. (1)
1.    Lamellae – concentric, cylinder-shaped layers of calcified
matrix
2.    Lacunae – small spaces containing tissue fluid in which
bone cells lie imprisoned between the hard layers of the lamellae
3.    Canaliculi – ultrasmall canals radiating in all directions
from the lacunae and connecting them to each other and into a
larger canal, the haversian canal
4.    Haversian canal – extends lengthwise through the center
of each Haversian system; contains blood vessels, lymphatic
vessels, and nerves from the Haversian canal; nutrients and
oxygen move through canaliculi to the lacunae and their bone
cells – a short distance of about 0.1 mm or less.
Three Major Types of Cells
Found in Bones

1.    Osteoblasts – bone-forming
cells
2.    Osteoclasts – bone-resorbing
cells
3.    Osteocytes – mature bone cells
Osteoblasts

Osteoblasts are small cells that synthesize
and secrete a specialized organic matrix,
called osteoid. (1)
Osteoclasts

Osteoclasts are giant multinucleate cells
that are responsible for the active erosion of
bone minerals. (1)
Osteocytes
Osteocytes are mature, non-dividing
osteoblasts that have become surrounded
by matrix and now lie within lacunae. (1)
Homeostatic Functions of
Bones
1.    Support: contributes to the shape, alignment, and
positioning of the body parts
2.    Protection: hard, bony “boxes” that serve to protect the
delicate structures they enclose
3.    Movement: bones with their joints constitute levers,
muscles are anchored firmly to bones, as muscles contract
and shorten, they pull on bones. Making it movement in a joint
4.    Mineral storage: depends on changes in the rate of
calcium movement between the blood and bones
5.    Hematopoiesis: blood cell formation
(1)
Intramembranous and
Endochondral bone
Intramembranous and Endochondral bone are two essential processes during
fetal development of the mammalian skeletal system by which bone tissue is
created

Intramembranous:
        · Cartilage is not present during intramembranous ossification
        · Intramembranous ossification is essential process during the natural
        healing of bone fractures and the rudimentary formation of bones of
        the head
Endochondral:
        · Cartilage is present during endochondral ossification
        · Essential process during the rudimentary formation of long bones,
        the growth of the length of long bones, and the natural healing of bone
        fractures.
Bone Fracture Repair
1.   White blood cells move in to the area to clean up debris created by
     the break, which creates inflammation, in turn triggering the growth
     of new blood cells
2.   New blood vessels develop to begin the healing process
3.   Soft callus also known as cartilage or soft fibrous tissue, begins to
     form to bridge the gap from the break.
4.   A harder cartilage develops in place of the soft cartilage, forming a
     more solid bond within the gap
5.   Through a process called remodeling, old bone is continually
     replaced by new bone, completing the process of bone fracture
     healing.
Bone and Cartilage
· A bone is a rigid organ that constitutes part of the
endoskeleton of vertebrates. It supports and protects the
various organs of the body, produces red and white blood
cells and stores minerals. Bone is made up of osteoblasts,
osteocytes, osteoclasts, and bone lining cells which
regulate the movement of calcium
· Cartilage is a flexible connective tissue found in many
areas in the bodies of humans and other animals, including
the joints between bones. Cartilage is made up of
chondroblasts, chondrocytes, and dense matrix made up of
collagen and elastic fibers

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Skeletal physiology

  • 2. Fibrous Joint Structure These types of joints are held together by fibrous connective tissue, no joint cavity is present. Either slightly mobile or immobile.
  • 3. Synovial Joint Structure Made up of synovial fluid, freely movable and characterize most joints. Subtypes- Hyaline Cartilage- Covers the end of the bone Synovial Membrane- Surrounds synovial cavity. Fibrous capsule- Made up of ligaments ( dense, irregular connective tissue) Articulate capsule- Both synovial and fibrous membrane.
  • 4. Types Of Movement SYNOVIAL JOINTS- All are freely movable (diarthrosis) Gliding- Two sliding surfaces Hinge- Concave surface with convex surface, diathrosis Pivot- Rounded end fits into ring Condyloid- oval condyle with oval cavity Saddle- each surface is concave or convex Ball&Socket- Ball shaped head, and cup shaped pocket
  • 5. Joint Types Pictures Synovial Fibrous Cartilaginous
  • 6. The Four Types of Bones ● Long Bones ● Short Bones ● Flat Bones ● Irregular Bones
  • 7. Long Bones These bones typically have an elongated shaft and two expanded ends one on either side of the shaft. The shaft is known as diaphysis and the ends are called epiphyses. Normally the epiphyses are smooth and articular. The shaft has a central medullary cavity where lies the bone marrow. Examples include the humerus, femur, radius, ulna, tibia and fibula
  • 8. Short Bones These bones are short in posture and can be of any shape. Most of them are named according to their shape. Examples of this class of bones include cuboid, cuneiform, scaphoid, trapezoid etc. In fact all the carpal and tarsal bones are included in this category.
  • 9. Flat Bones These bones are flat in appearance and have two prominent surfaces. They resemble shallow plates and form boundaries of certain body cavities. Examples include scapula, ribs, sternum etc.
  • 10. Irregular Bones The shape of these bones is completely irregular and they do not fit into any category of shape. Examples of this type of bones are vertebrae, hip bone and bones in the base of skull.
  • 11. Major Structures of a Long Bone ● The diaphysis, or shaft, is the long tubular portion of long bones. It is composed of compact bone tissue. ● The epiphysis (plural, epiphyses) is the expanded end of a long bone. It is in the epiphyses where red blood cells are formed. ● The metaphysis is the area where the diaphysis meets the epiphysis. It includes the epiphyseal line, a remnant of cartilage from growing bones. ● The medullary cavity, or marrow cavity, is the open area within the diaphysis. The adipose tissue inside the cavity stores lipids and forms the yellow marrow. ● Articular cartilage covers the epiphysis where joints occur. ● The periosteum is the membrane covering the outside of the diaphysis (and epiphyses where articular cartilage is absent). It contains osteoblasts (bone-forming cells), osteoclasts (bone-destroying cells), nerve fibers, and blood and lymphatic vessels. Ligaments and tendons attach to the periosteum. ● The endosteum is the membrane that lines the marrow cavity.
  • 13. Bone as a Tissue There are two different kinds of bone tissue: Compact and Spongy bone. Compact bone ● Is made up of concentric rings of matrix that surround central canals which contain blood vessels. ● Embedded in this bone tissue are small cave-like spaces called lacunae, which are connected to each other through small tunnels called canaliculi. ● The lacunae contain osteocytes cells. As just discussed, osteocytes help maintain healthy bone tissue and are involved in the bone remodeling process that will be outlined later in this lesson. Spongy bone ● Looks like an irregular latticework (or sponge) with lots of spaces throughout. ● These spaces are filled with red bone marrow which is the site of hematopoiesis or formation of blood cells.
  • 14. The Haversian System A Haversian System consists of many cylinder-shaped structural units. There are four types of structures that make up each Haversian system. (1) 1. Lamellae – concentric, cylinder-shaped layers of calcified matrix 2. Lacunae – small spaces containing tissue fluid in which bone cells lie imprisoned between the hard layers of the lamellae 3. Canaliculi – ultrasmall canals radiating in all directions from the lacunae and connecting them to each other and into a larger canal, the haversian canal 4. Haversian canal – extends lengthwise through the center of each Haversian system; contains blood vessels, lymphatic vessels, and nerves from the Haversian canal; nutrients and oxygen move through canaliculi to the lacunae and their bone cells – a short distance of about 0.1 mm or less.
  • 15. Three Major Types of Cells Found in Bones 1. Osteoblasts – bone-forming cells 2. Osteoclasts – bone-resorbing cells 3. Osteocytes – mature bone cells
  • 16. Osteoblasts Osteoblasts are small cells that synthesize and secrete a specialized organic matrix, called osteoid. (1)
  • 17. Osteoclasts Osteoclasts are giant multinucleate cells that are responsible for the active erosion of bone minerals. (1)
  • 18. Osteocytes Osteocytes are mature, non-dividing osteoblasts that have become surrounded by matrix and now lie within lacunae. (1)
  • 19. Homeostatic Functions of Bones 1. Support: contributes to the shape, alignment, and positioning of the body parts 2. Protection: hard, bony “boxes” that serve to protect the delicate structures they enclose 3. Movement: bones with their joints constitute levers, muscles are anchored firmly to bones, as muscles contract and shorten, they pull on bones. Making it movement in a joint 4. Mineral storage: depends on changes in the rate of calcium movement between the blood and bones 5. Hematopoiesis: blood cell formation (1)
  • 20. Intramembranous and Endochondral bone Intramembranous and Endochondral bone are two essential processes during fetal development of the mammalian skeletal system by which bone tissue is created Intramembranous: · Cartilage is not present during intramembranous ossification · Intramembranous ossification is essential process during the natural healing of bone fractures and the rudimentary formation of bones of the head Endochondral: · Cartilage is present during endochondral ossification · Essential process during the rudimentary formation of long bones, the growth of the length of long bones, and the natural healing of bone fractures.
  • 21. Bone Fracture Repair 1. White blood cells move in to the area to clean up debris created by the break, which creates inflammation, in turn triggering the growth of new blood cells 2. New blood vessels develop to begin the healing process 3. Soft callus also known as cartilage or soft fibrous tissue, begins to form to bridge the gap from the break. 4. A harder cartilage develops in place of the soft cartilage, forming a more solid bond within the gap 5. Through a process called remodeling, old bone is continually replaced by new bone, completing the process of bone fracture healing.
  • 22. Bone and Cartilage · A bone is a rigid organ that constitutes part of the endoskeleton of vertebrates. It supports and protects the various organs of the body, produces red and white blood cells and stores minerals. Bone is made up of osteoblasts, osteocytes, osteoclasts, and bone lining cells which regulate the movement of calcium · Cartilage is a flexible connective tissue found in many areas in the bodies of humans and other animals, including the joints between bones. Cartilage is made up of chondroblasts, chondrocytes, and dense matrix made up of collagen and elastic fibers