Eltroxin Tablets (Levothyroxine Sodium) is used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. Levothyroxine is also used to help decrease the size of enlarged thyroid glands and reduce the symptoms of low thyroid hormone.

1. Eltroxin Tablets
Eltroxin contains Levothyroxine
Sodium that is identical to the
thyroid hormone produced in the
human thyroid gland. It is used to
treat hypothyroidism, a condition
where the thyroid gland does not
produce enough thyroid hormone.
Levothyroxine is also used to help
decrease the size of enlarged
thyroid glands (also called a goiter).
Eltroxin helps to reduce the
symptoms of low thyroid hormone
such as weight gain, sensitivity to
cold, lack of energy, and dry skin.
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2. Eltroxin Tablets
Active Ingredient
The active ingredient present
in Eltroxin Tablets is
Levothyroxine Sodium.
Eltroxin 50 mcg contains 50
micrograms (0.05 mg) of
Levothyroxine Sodium whereas
Eltroxin 100 mcg contains 100
micrograms (0.1 mg) of
Levothyroxine Sodium.
The inactive ingredients
present are as per the old
formula of GlaxoSmithKline.
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3. Eltroxin Tablets
Chemical Structure
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4. Eltroxin Tablets
Inactive ingredients present in Eltroxin 25 mcg tablets:
➔Sodium Citrate
➔Lactose
➔Starch Maize
➔Acacia Powder
➔Magnesium Stearate
➔Purified Water
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5. Eltroxin Tablets
Inactive ingredients present in Eltroxin 50 mcg tablets:
➔Sodium Citrate
➔Lactose
➔Starch Maize
➔Acacia Powder
➔Magnesium Stearate
➔Purified Water
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6. Eltroxin Tablets
Inactive ingredients present in Eltroxin 100 mcg tablets:
➔Sodium Citrate
➔Lactose
➔Starch Maize
➔Gelatin
➔Methyl Hydroxybenzoate
➔Propyl Hydroxybenzoate
➔Magnesium Stearate
➔Purified Water
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7. Eltroxin Tablets
Recommended Adult Dosage
Eltroxin is administered as a single daily
dose, on an empty stomach preferably
one-half to one hour before breakfast.
Eltroxin tablets should be taken at least 4
hours apart from medicines that are known
to interfere with its absorption.
The Initial recommended dose is 50 to
100 micrograms daily and adjusted at four
or six week intervals by 50 micrograms
until attainment of adequate clinical
response.
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8. Eltroxin Tablets
Administration
➔Should preferably be taken on an empty
stomach
➔Should be swallowed whole
➔Should be taken with a full glass of water
➔Eltroxin tablets should not be split
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9. Eltroxin Tablets
Contraindications
➔Hypersensitivity to Levothyroxine Sodium
or any inactive ingredient of the
preparation.
➔Patients with untreated subclinical or overt
thyrotoxicosis
➔Patients with acute myocardial infarction
➔Patients with uncorrected adrenal
insufficiency
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10. Eltroxin Tablets
Possible Side Effects
➔Immune system disorders: Hypersensitivity
reactions such as skin rash and pruritis
➔Metabolism and nutrition disorders: Increased
appetite, abdominal cramps, nausea, vomiting
and diarrhea
➔Nervous system disorders: Excitability,
insomnia, restlessness, headache, tremors,
seizure
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11. Eltroxin Tablets
Possible Side Effects
➔Cardiac disorders: Anginal pain, cardiac
arrhythmias, palpitations, tachycardia, increased
blood pressure, heart failure, myocardial
infarction
➔Respiratory, thoracic and mediastinal disorders:
Dysponea
➔Skin and subcutaneous tissue disorders:
Sweating, flushing, hair loss
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12. Eltroxin Tablets
Possible Side Effects
➔Musculoskeletal, connective tissue and bone
disorders : Cramps in the skeletal muscle,
muscular weakness, decreased bone mineral
density.
➔Reproductive system and breast disorders:
Menstrual irregularity, impaired fertility
➔General disorders and administration site
conditions: Fatigue, heat intolerance, fever,
excessive loss of weight.
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13. Eltroxin Tablets
Warnings And Precautions
➔Appropriate thyroxine dosage is based upon
clinical assessment and laboratory monitoring of
thyroid function tests. During the initial titration
period, careful dosage titration and monitoring is
necessary to avoid the consequences of under- or
over-treatment.
➔Treatment with thyroxine in patients with
panhypopituitarism or other causes predisposing to
adrenal insufficiency may cause reactions including
dizziness, weakness, malaise, weight loss,
hypotension and adrenal crisis. It is advisable to
initiate corticosteroid therapy before giving
levothyroxine sodium in these cases.
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14. Eltroxin Tablets
Warnings And Precautions
➔Special care is needed in the elderly and in
patients with symptoms of myocardial insufficiency
or ECG evidence of myocardial infarction or
ischaemia and also those with diabetes mellitus or
insipidus.
➔Levothyroxine raises blood sugar levels and this
may upset the stability of patients receiving
antidiabetic agents.
➔Levothyroxine is excreted in breast milk in low
concentrations and this may be sufficient to
interfere with neonatal screening for hypothroidism.
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15. Eltroxin Tablets
Warnings And Precautions
➔In women, long-term levothyroxine sodium
therapy has been associated with increased bone
resorption, thereby decreasing bone mineral
density, especially in post-menopausal women on
greater than replacement doses or in women who
are receiving suppressive doses of levothyroxine
sodium.
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16. Eltroxin Tablets
Overdose Symptoms
In addition to exaggeration of side effects the
following symptoms may be seen: agitation,
confusion, irritability, hyperactivity, headache,
sweating, mydriasis, tachycardia, arrhythmias,
tachypnoea, pyrexia, increased bowel movements
and convulsions.
Cerebral embolism, shock, coma, and death have
also been reported. Seizures have occurred in a
child ingesting 18 mg of levothyroxine. Symptoms
may not necessarily be evident or may not appear
until several days after ingestion of Levothyroxine
Sodium.
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17. Eltroxin Tablets
Overdose Treatment
Levothyroxine Sodium should be reduced in
dose or temporarily discontinued if signs or
symptoms of overdosage occur.
In case of an acute overdose, symptomatic
and supportive therapy should be instituted
immediately. If not contraindicated (e.g., by
seizures, coma, or loss of the gag reflex), the
stomach should be emptied by emesis or
gastric lavage to decrease gastrointestinal
absorption. Activated charcoal or
cholestyramine may also be used to decrease
absorption.
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18. Eltroxin Tablets
Overdose Treatment
Central and peripheral increased sympathetic
activity may be treated by administering Beta-receptor
antagonists, e.g., propranolol, provided
there are no medical contraindications to their use.
Provide respiratory support as needed; control
congestive heart failure and arrhythmia; control
fever, hypoglycemia, and fluid loss as necessary.
Large doses of antithyroid drugs (e.g., methimazole
or propylthiouracil) followed in one to two hours by
large doses of iodine may be given to inhibit
synthesis and release of thyroid hormones.
Glucocorticoids may be given to inhibit the
conversion of T4 to T3.
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19. Eltroxin Tablets
Eltroxin Tablets 25 mcg, 50 mcg &
100 mcg from GlaxoSmithKline.
For more information click here
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