5. The less abundant blood supply in adipose tissue results in a potential delay in vaccine antigen presentation to the B and T cells that are responsible for immune response; this delay may allow the protein antigens to be denatured by enzymes , resulting in a diminished immune response to vaccination. Effect of Needle Length When Immunizing Obese Adolescents With Hepatitis B Vaccine Middleman Pediatrics 2010;125:e508
25. Increased risk of serious pneumococcal disease (SPD) in patients with atopic conditions other than asthma Jung JACI 2010:125:217 Background: We reported an increased risk of serious pneumococcal disease ( SPD ) among patients with asthma. It is not known whether this is true for patients with other atopic conditions. Objective: To determine the relationship between atopic conditions other than asthma and SPD.
39. Proportion of isolates nonsusceptible (intermediate plus resistant) to clindamycin and erythromycin. Serotype 19A Is the Most Common Serotype Causing Invasive Pneumococcal Infections in Children Kaplan Pediatrics 2010;125:429 The number of invasive pneumococcal isolates per penicillin MIC for isolates in 2007 and 2008.
40.
41. 1) Currently, serotype 19A is the most common serotype for invasive disease in children . Serotype 19A also has become an important pneumococcal isolate causing otitis media and its complications such as mastoiditis. 2) In a multicenter study, pneumococcal pneumonia in children caused by isolates with penicillin MICs up to 4 µg/mL was treated successfully with intravenous penicillin or ampicillin. 3) For some patients with invasive infection, such as pneumonia or pleural empyema caused by a multidrug-resistant serotype 19A isolate, linezolid or perhaps a newer quinolone might be the only oral agents available for completing therapy. 4) Intravenous therapy with ceftriaxone and cefotaxime remains an appropriate treatment option for such patients as well. Serotype 19A Is the Most Common Serotype Causing Invasive Pneumococcal Infections in Children Kaplan Pediatrics 2010;125:429