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Parkinsonism

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Uma Bhosale (Kadam)
Uma Bhosale (Kadam)
Health & Medicine
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DR.UMA KADAM M.B.B.S. MD ASSOCIATE PROFESSOR PHARMACOLOGY SKNMC
ANTI-PARKNSONIAN DRUGS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],Dopamine Acetylcholine
GABA DOPAMINE ACETYLCHOLINE PARKINSONISM + -
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DRUGS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
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[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pathophysiology of Parkinson’s Disease Increased production of free radicals (reactive oxygen species) and deficiency of antioxidant mechanisms O 2 O 2 H 2 O 2 OH • - 2H 2 O Hydroxyl radical Hydrogen peroxide Superoxide radical +e - +e - + OH - 2H + +e - +e - ,[object Object],[object Object],[object Object],[object Object]
Evidence for Free Radical Hypothesis ,[object Object],[object Object],[object Object],[object Object],[object Object]
↓ GSH Mitochondrial Damage ↑ H 2 O 2 FREE RADICALS Cell Death Mitochondrial Damage Excitotoxicity ↑ Cytosolic Ca 2+ Ca 2+ activated Degradative enzymes DA Fe 2+ ↑ Free radical Production (?PD) ↓ Free radical Defenses (?ALS)
"On/off" Effect: ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
DRUG INTERACTIONS WITH L DOPA: ,[object Object],[object Object],[object Object],[object Object]
DRUG INTERACTIONS CONT…… ,[object Object],[object Object],[object Object]
DRUG INTERACTIONS CONT……. ,[object Object]
On the Horizon ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
THANK YOU

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Parkinsonism

  • 1. DR.UMA KADAM M.B.B.S. MD ASSOCIATE PROFESSOR PHARMACOLOGY SKNMC
  • 2.
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  • 4. GABA DOPAMINE ACETYLCHOLINE PARKINSONISM + -
  • 5.
  • 6.
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  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17. ↓ GSH Mitochondrial Damage ↑ H 2 O 2 FREE RADICALS Cell Death Mitochondrial Damage Excitotoxicity ↑ Cytosolic Ca 2+ Ca 2+ activated Degradative enzymes DA Fe 2+ ↑ Free radical Production (?PD) ↓ Free radical Defenses (?ALS)
  • 18.
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  • 24.