5. • Axon terminal- terminal branch of nerve fiber
• Motor end plate- bulb like expansion of axon
terminal
• Synaptic trough/ gutter- depression on the
muscle fiber due to invagination of motor end
plate
• Subneural cleft- numerous folds of post
synaptic membrane
6. • Presynaptic membrane- membrane of nerve
ending
• Postsynaptic membrane- membrane of
muscle fiver
• Synaptic cleft- space between post and
presynaptic membrane
• Basal lamina- thin spongy layer of reticular
matrix in synaptic cleft
7. Neuromuscular transmission
• Transfer of information
from motor nerve
ending to the muscle
fiber through
neuromuscular junction
to initiate muscle
contraction
8. Series of events
1.
2.
3.
4.
Release of acetly choline
Action of acetly choline
Development of end plate potential
Development of miniature end plate
potential
5. Destruction of acetyl choline
14. Neuromuscular blockers
Drugs which prevent
transmission of impulse
across neuromuscular
junction
significance..?
useful in surgical and
trauma care
15. • Curare blocks ach receptors by binding
• Bungarotoxin - (snake venom extract)
blocks ach receptors
• Botulinum toxin - (clostridium botulinum)
prevents realease of ach from axon terminal
17. Motor unit
• Motor neuron, axon
terminal and muscle
fibers together called as
motor unit
18. • Muscles involved in fine movements- less
muscle fibers in motor unit
ex: movement of eyes- ocular muscles
• Muscles involved in coarse movements- more
muscle fibers in motor unit
ex: flexion – leg muscles
19. Recruitment of motor units
• Process by which more
and more motor units
are put into action
• Force of contraction
increases
21. 1. Eaton lambert syndrome
- autoimmune disorder of NMJ
- antibodies- calcium channels in axon
terminal
22. Question of previous year
• Neuromuscular junction- (5m)- aug 2006
• Draw a neat diagram of neuromuscular
junction. Describe the transmission of impulse
across neuromuscular junction- (10m)- jan
2008
