drug technology needs drug delivery technology - VIRUN

1. VIRUN ® intricate scien c e www.virun.com © VIRUN 2011 Virun is a registered trademark of Virun, Inc. All rights reserved

3. About Virun Biotechnology company established in 2003. 48 employees Facilities in Walnut, CA. and China Focus on particle augmentation for improved delivery of naïve compounds and peptides Industries: Food and Beverage Supplements Drugs

4. we are a biotechnology company… ..focusing on improving the delivery of naive compounds and peptides VIRU N ®

5. food and beverage

6. no fish taste

7. clear dissolving

8. fortified apple juice with omega-3 dha & epa, vitamins d3, k and e apple juice fortified grape juice with omega-3 dha & epa, vitamins d3, k and e grape juice fortified waters with omega-3 dha & epa, vitamins d3, k and e fortified water fortified water with juice - omega-3 dha & epa, vitamins d3, k and e water juices … vegetarian and fish oil omega-3 dha epa

9. Targeting a specific cell, cell receptor or cell wall can promote better delivery to engage a more pronounced therapeutic effect i n n e r s e life sciences A VIRUN ® collaboration

10. MAPD binds peptides to transferrin and delivers peptides to blood orally. MAPD allows therapeutic administration of peptides without the use of needles. i n n e r s e life sciences A VIRUN ® collaboration

11. Increased drug performance… … Increased drug success i n n e r s e life sciences A VIRUN ® collaboration

12. MAPD delivers peptides orally and can completely avoid stomach digestion and enzymatic degradation. i n n e r s e life sciences A VIRUN ® collaboration

13. “… Tf-Fe is the generally accepted physiological mode of iron of delivery to cells.” MAPD-drug-LtF delivery…. MAPD technology i n n e r s e life sciences A VIRUN ® collaboration

14. MAPD-drug-LtF delivery…. MAPD technology … MAPD is the only patented delivery that enables Tf endocytosis as a mechanism for peptide oral delivery. i n n e r s e life sciences A VIRUN ® collaboration

15. MAPD has shown near 100% oral bioavailability of peptides compared to subcutaneous and intravenous injection. i n n e r s e life sciences A VIRUN ® collaboration

16. MAPD binds the LRP1 receptor and delivers the peptide drug orally. i n n e r s e life sciences A VIRUN ® collaboration

17. MAPD-siRNA-LtF delivery…. ONCOLOGY i n n e r s e life sciences A VIRUN ® collaboration

19. Targeting a specific cell, cell receptor or cell wall can promote better delivery to engage a more pronounced therapeutic effect A B C i n n e r s e life sciences A VIRUN ® collaboration

20. VIRU N ®

21. Good Manufacturing Practices (GMP) is…. 3 hours of actual production and 3 weeks of testing, documentation and verification QC raw materials, Production, QC finished products Q.C. Q.C. Q.C. Q.C. Q.C. Q.C. Q.C. … issue Certificate of Analysis Proposition 65 & Heavy metals – ICP/MS Assay = FTIR, HPLC, LCMSMS MS VIRU N ®

22. VIRUN ® intricate science VIRUN 21118 Commerce Pointe Dr. Walnut, CA. 91789 Ph: (909) 839-0629 www.virun.com