NDD30503: NUTRITION FOR SPORTS AND EXERCISE

NUTRITION FOR SPORT
AND EXERCISE
NDD30503
ASSOC PROF. DR. SHARIFAH WAJIHAH WAFA BTE SST WAFA
EC22
SUNDAY
1100-1300
Minerals
Lecture 7
Learning Objectives
1. Classify minerals and describe their general
roles.
2. Explain how mineral inadequacies and
excesses can occur and why each might be
detrimental to performance and health.
3. Describe the factors that increase, maintain,
and decrease bone mineral density,
including a discussion of the minerals
associated with bone formation and their
effects on performance and health.
Learning Objectives
4. Describe the role of iron in red blood cell
formation and the impact of low iron intake
on performance and health.
5. Describe the roles of minerals in the immune
system.
6. Compare and contrast minerals based on their
source—naturally occurring in food, added to
foods during processing, and found in
supplements—including safety and
effectiveness..
Introduction
 Minerals differ from vitamins in
many ways
 Inorganic, not well absorbed, not
easily excreted
Classification of minerals
 There are 21 essential minerals.
 A RNI and UL have been established for
most minerals.
 Moderate to rigorous exercise may
increase the loss of some minerals,
which typically can be replaced with
properly chosen foods.
Classification of minerals
 Amount found in the body
1. Macrominerals
a. Found in relatively large amounts
b. Calcium, phosphorous, magnesium
c. Sodium, potassium, chloride, sulfur
2. Microminerals (trace minerals)
a. Iron, zinc, copper, selenium
b. Others such as manganese and
molybdenum
Classification of minerals
 Functionality
1. Proper bone formation
a. Calcium, phosphorus, magnesium,
fluoride
2. Electrolytes
a. Sodium, potassium, chloride
3. Enzyme-related functions
a. Iron, zinc, selenium, copper
Classification of minerals
 Moderate to rigorous exercise
increases the loss of some minerals
1. Mineral loss in sweat and urine may
be greater in athletes
2. Adaptation to conserve some
minerals as athletes acclimate to heat
Classification of minerals
 Moderate to rigorous exercise increases
the loss of some minerals
3. Small to moderate losses can be offset by
dietary intake
4. Larger losses may need supplementation
5. Zinc moves from muscle cells into the
ECF and might be excreted in urine
Classification of minerals
 Poor food choices by athletes and sedentary
people often lead to low mineral intake:
1. Athletes likely low in dietary calcium, iron,
zinc, selenium, magnesium, copper
2. Energy-restricted athletes at the most risk
3. Nutrient-dense foods are important to meet
overall needs
4. The best approach for determining mineral
intake is personalised dietary assessment for
each athlete
Mineral deficiencies and toxicities
 Mineral homeostasis
1. Generally maintained by adjusting
absorption and excretion
a. If storage is high, absorption decreases
b. If storage is low, absorption increases
2. Hormonal and other mechanisms are also
influential
Mineral deficiencies and toxicities
1. Factors that increase mineral absorption
Presence of a growth state
Presence of a deficiency state
Larger (vs. smaller) amounts consumed in food
Presence of food in the GI tract
Certain compounds in food (e.g., vitamin C, soluble fiber,
MFP factor)
Certain chemical forms
Mineral deficiencies and toxicities
2. Factors that decrease mineral absorption
Increasing age
Poor health or GI disease
Presence of competing minerals
Certain compounds found in food (e.g., phytic acid, insoluble fiber)
Excessive supplementation of individual minerals
Presence of food in the GI tract
pH of the GI tract
GI transit time
 It is important to guard against mineral
deficiencies
1. General characteristics
a. Deficiencies develop over time
b. No signs or symptoms initially
c. Signs or symptoms are non-specific when they
first occur
d. Specific symptoms associated with severe
deficiencies
Mineral deficiencies and toxicities
 It is important to guard against mineral
deficiencies
2. Prevalence of subclinical mineral deficiencies
a. Iron deficiency without anemia
i. Prevalence may be higher in female
endurance athletes and vegetarians
ii. Effect on performance not known but it is
prudent to avoid this condition
b. Osteopenia
i. Low bone mineral density
ii. May be as high as 11-22% of athletes
Mineral deficiencies and toxicities
c. It is reasonable to assume some athletes could
have subclinical deficiencies of iron, calcium,
zinc, selenium, and magnesium
d. Subclinical deficiencies of other minerals not well
documented
Mineral deficiencies and toxicities
3. Prevalence of clinical mineral deficiencies
a. Iron-deficiency anemia
i. Prevalence in female athletes estimated to be 3% or
more
ii. Prevalence in male athletes very low but not zero
iii. Results in fatigue and impaired performance
Mineral deficiencies and toxicities
b. Osteoporosis
i. Bone loss exacerbated
with low estrogen
(associated with
inadequate dietary
intake, low caloric intake,
and low body fat)
ii. 10-13% female distance
runners
iii. Small % of amenorrheic
female distance runners
< age 30
c. Clinical deficiencies
negatively affect
performance and health
Mineral deficiencies and toxicities
 Bone-forming minerals
1. 90% is calcium and phosphorus, used to form
hydroxyapatite
2. Small amount of fluoride
3. Several minerals have indirect roles
4. Vitamin D is critical to bone development
The roles of minerals in bone formation
 Bones have both structural and metabolic
functions
1. Bone growth, modeling, and remodeling
The roles of minerals in bone formation
Increased length and thickness during childhood and adolescence
Growth is longitudinal (length) and radial (thickness)
Modeling is the process in which bones are formed and shaped
Mechanical stress strengthens bones
Increased mineral content until approximately age 35
Slow mineral loss after approximately age 35
Accelerated mineral loss in females when estrogen production declines
The roles of minerals in bone formation
2. Bone remodeling
a. Bone turnover is constant
b. Site of bone remodeling
i. Cortical bone
• approximately 80% of skeleton
• Shafts of the long bones and on the surface
The roles of minerals in bone formation
ii. Trabecular bone
• approximately 20% of skeleton
• Ends of the long bones and under the surface
• Honeycomb-like structure
• Greater surface volume, metabolic activity, and turnover
The roles of minerals in bone formation
c. Rate and time of bone remodeling
i. Rate
• 1-2% of entire skeleton but approximately 20% of
trabecular bone
• approximately 1 million active sites each day
ii. Length of time
• In children, weeks
• In young adults, approximately 3 months
• In older adults, approximately 6 to 18 months
• Over a ten-year timeframe an adult’s skeleton will
be completely remodeled
d. Osteoclasts resorb bone
i. Stimulated by physical activity and
microfractures
ii. Stimulated by hormones—PTH and calcitriol
e. Osteoclast/osteoblast balance
i. In children and adolescents, deposition is
favored
ii. In young adults, balance generally exists
iii. In middle-aged to older adults, resorption is
favored (more osteoclastic activity)
The roles of minerals in bone formation
 Achieving peak bone mineral density is critical to
long-term health
1. Highest lifetime bone mineral density
a. Trabecular bone by approximately age 30
b. Cortical bone by approximately age 35
2. Approximately 60% is genetically determined
3. Important influences
a. Adequate calcium, vitamin D, and protein intakes
b. Weight-bearing exercise or activity or high-
impact exercise (jumping, strength training)
c. Hormones
The roles of minerals in bone formation
4. Nutritional factors affecting peak bone density
a. Calcium
i. Greatest amount needed for ages 9 to 18
(1,300 mg/day)
ii. Substantial need throughout adulthood
(1,000 to 1,200 mg/day)
b. Vitamin D
i. 5 mcg/day until age 50
ii. Need increases with age
• 10 mcg ages 51 to 69; 15 mcg age 70 and above
• Conversion to active form declines
• Exposure to UV light declines
The roles of minerals in bone formation
c. Protein
i. Adequate protein in children is associated
with bone growth
ii. Necessary for secretion of IGF-1
5. Mechanical factors affecting peak bone density
a. Weight-bearing exercise
b. High-impact activities
c. Excess body weight
The roles of minerals in bone formation
5. Bone loss associated with aging
The roles of minerals in bone formation
In women, 0.25 to 1.0% yearly until age 50
With estrogen deficiency, 1-2% yearly (mainly from vertebrae)
In the decade after menopause, 20-30% of bone density from trabecular bone
and 5-10% from cortical bone
In older men, approximately 1% yearly
Bone loss associated with low calcium availability for functional use and to
maintain calcium homeostasis
Under hormonal regulation
Normal calcium excretion is approximately300 mg between GI secretions and
urine losses
The roles of minerals in bone formation
6. Calcium may be taken
from bone to maintain
calcium homeostasis
a. Hormonally controlled
i. Parathyroid hormone
(PTH)
ii. Calcitriol (form of vitamin
D)
The roles of minerals in bone formation
b. Calcium homeostasis
i. Regulation of calcium in
the blood and extracellular
fluid
ii. Primarily controlled by PTH
iii. Critical for proper nerve
and muscle function
iv. Fast calcium exchange
• PTH activates calcium
pumps in membranes
surrounding bone fluid
• Calcium is mobilized
from bone fluid not
mineralized bone
• PTH stimulates calcium
resorption in kidney and
increased GI absorption
3. Calcium balance
a. Total absorption, distribution, and excretion
b. Different from calcium homeostasis but related
c. Increased or decreased absorption and excretion
as needed
d. Bone turnover is balanced under normal
conditions
The roles of minerals in bone formation
4. Long-term low calcium intake
a. Bone turnover is not balanced
b. Slow calcium exchange
i. PTH stimulates dissolution of bone
ii. Increases osteoclastic activity; decreases
osteoblastic activity
iii. Calcium (and phosphate) released from bone
iv. Over time, integrity of bone is decreased
The roles of minerals in bone formation
 Bone loss is associated with lack of estrogen
The roles of minerals in bone formation
Powerful influence on osteoclast number and activity
Generally associated with menopause
Also present in some young female athletes
Distance runners, ballerinas, and gymnasts are at greater risk
Focus on research: Does the Disruption of the Menstrual Cycle That
Occurs in Some Athletes Have Health Implications?
 The roles of calcium and exercise in preventing
or reducing bone loss associated with aging
have not been fully established
1. Diet-related
a. In women after age 70, calcium supplementation
is beneficial
b. Calcium supplementation after age 35 may be
prudent to slow calcium losses from bones
c. Calcium supplementation in this group will not
offset all of the factors that affect a decline in
BMD
The roles of minerals in bone formation
d. In women under 50 and most men, adequate
calcium and vitamin D intakes slow the loss of
bone calcium
e. In the first 10 years after menopause, calcium
supplementation has a small, positive effect
2. Exercise-related
a. High-intensity weight-bearing activities
b. Resistance training
c. Mechanical stress increases bone density
d. Other types of exercise are beneficial but do not
slow bone loss
The roles of minerals in bone formation
 There are numerous strategies for increasing
dietary calcium consumption
1. Calcium sources
a. Milk and milk products
b. Reduced-lactose or lactase-treated milk products
c. Fermented milk products
d. Calcium-containing vegetables such as cabbage,
broccoli, and green leafy vegetables
e. Calcium-fortified foods
f. Calcium supplements
The roles of minerals in bone formation
2. Many people consume an inadequate amount
of calcium daily
3. Over-consumption of calcium supplements (UL
2500 mg/day) can lead to kidney stones and
displacement of other nutrients
 Phosphorus, fluoride, and magnesium are also
involved with bone health
1. Phosphorus is abundant in food
2. Fluoride is added to supplements or water
3. Magnesium is found in vegetables, nuts, beans,
and legumes
The roles of minerals in bone formation
The roles of minerals in blood formation
 Iron is an integral part of hemoglobin
1. Hemoglobin
a. Iron-containing protein
b. Necessary for oxygen, carbon dioxide, and nitric
oxide transport
c. Normal: 12.1 to 15.1 g/dl in females; 13.8 to 17.2
g/dl in males
2. Hematocrit
a. Measure of oxygen-carrying capacity
b. Expressed as % of total blood plasma volume
c. Normal: approximately 42% in females;
approximately 45% in males
The roles of minerals in blood formation
3. Iron deficiency anemia
a. Most common nutrition-related anemia
b. Low iron stores may be due to:
i. Poor intake
ii. Poor absorption
iii. Excessive blood loss
The roles of minerals in blood formation
 Blood tests can help detect iron deficiency
1. Common measures are hemoglobin, hematocrit,
and ferritin
2. Iron status declines over time
a. As iron stores are being depleted, hemoglobin
and hematocrit do not decline initially
b. Serum ferritin concentration declines
3. False (runner’s) anemia
The roles of minerals in blood formation
 Iron-deficiency anemia negatively affects
performance
1. Iron-deficiency anemia impairs performance
a. VO2max (aerobic capacity) declines
b. Endurance capacity declines
c. A decrease in iron-containing compounds
decreases oxygen utilization
2. Effect of iron deficiency without anemia on
performance is unclear
The roles of minerals in blood formation
 The prevalence of iron deficiency and iron-deficiency
anemia in female athletes is likely higher than in the
general population
Unlikely in most males (<2% in males under 70 years old)
Infrequently seen in adolescent males or male endurance
athletes (5%)
Some medications induce bleeding and loss of iron
Greatest risk is for menstruating females
Athletes with low caloric intake are at greater risk
Sweat loss
Iron loss in feces and urine in times of intensive training
The roles of minerals in blood formation
 Athletes should consume a variety of iron-
containing foods
1. Adequate energy intake
2. Variety of iron-dense foods
3. Heme (animal) sources are better absorbed than
nonheme (plant) sources
4. Vitamin C increases iron absorption
The roles of minerals in the immune
system
 The immune system protects the body from
disease
1. Immunity
a. Non-specific immunity (skin, respiratory system,
and GI tract)
b. Specific antibodies
c. Cytokines regulate the immune system
The roles of minerals in the immune
system
2. Zinc
a. Widely found in cellular enzymes
b. Involved in various immune functions
c. Most endurance athletes (approximately90%) do
not meet the RNI
d. Overtraining and zinc deficiency can result in
repeated URTI
e. Supplementation (low dose) is appropriate when
RNI isn’t met through the diet
f. supplemental zinc can interfere with iron and
copper absorption and decrease lymphocyte
response
The roles of minerals in the immune
system
3. Selenium
a. Involved in cellular and immune system function
b. Found in meat, fish, poultry, whole grains, and
nuts
c. Depressed immunity is associated with
deficiency
4. Iron
a. Plays important role in immune system functions
b. Excess iron impairs immune function
The adequate intake of all minerals
 The key to obtaining all the minerals needed
from food is to consume a nutrient-dense,
whole-foods diet
A varied, nutrient-
dense diet can
provide adequate
amounts of minerals
High-sugar/high-fat
diets often do not
meet daily mineral
requirements
Consume an
adequate amount of
calcium and iron
from food
The adequate intake of all minerals
 The dose and potency of a mineral supplement
can vary substantially from brand to brand
1. Mineral-fortified foods
a. Some foods have many minerals added
b. Degree of absorption is unknown
2. Multimineral supplements
a. Dosages may exceed the RNI or UL for some
nutrients
b. Degree of absorption is not known
The adequate intake of all minerals
3. Supplementing with individual minerals
a. Calcium and iron are most common
b. Should be physician prescribed, not self
prescribed
c. Likely to affect absorption of other minerals
d. High bioavailability may not be desirable
The adequate intake of all minerals
4. Spotlight on supplements:
How Beneficial is Chromium
Supplementation for
Athletes?
a. Some may contain highly
absorbable form
b. Enhances insulin sensitivity
c. Effectiveness for increasing
muscle mass and decreasing
body fat unclear
 4 minerals critical for bone formation:
 3 major electrolytes:
 3 trace elements that may be lost in sweat or
urine:
 4 food components that inhibit mineral
absorption:
 2 types of cells involved in skeletal growth:
 2 hormones that regulate calcium balance:
 3 serum values used to evaluate iron status:
 3 rich food sources of copper:
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NDD30503: NUTRITION FOR SPORTS AND EXERCISE

  • 1. NUTRITION FOR SPORT AND EXERCISE NDD30503 ASSOC PROF. DR. SHARIFAH WAJIHAH WAFA BTE SST WAFA EC22 SUNDAY 1100-1300
  • 3. Learning Objectives 1. Classify minerals and describe their general roles. 2. Explain how mineral inadequacies and excesses can occur and why each might be detrimental to performance and health. 3. Describe the factors that increase, maintain, and decrease bone mineral density, including a discussion of the minerals associated with bone formation and their effects on performance and health.
  • 4. Learning Objectives 4. Describe the role of iron in red blood cell formation and the impact of low iron intake on performance and health. 5. Describe the roles of minerals in the immune system. 6. Compare and contrast minerals based on their source—naturally occurring in food, added to foods during processing, and found in supplements—including safety and effectiveness..
  • 5. Introduction  Minerals differ from vitamins in many ways  Inorganic, not well absorbed, not easily excreted
  • 6. Classification of minerals  There are 21 essential minerals.  A RNI and UL have been established for most minerals.  Moderate to rigorous exercise may increase the loss of some minerals, which typically can be replaced with properly chosen foods.
  • 7. Classification of minerals  Amount found in the body 1. Macrominerals a. Found in relatively large amounts b. Calcium, phosphorous, magnesium c. Sodium, potassium, chloride, sulfur 2. Microminerals (trace minerals) a. Iron, zinc, copper, selenium b. Others such as manganese and molybdenum
  • 8. Classification of minerals  Functionality 1. Proper bone formation a. Calcium, phosphorus, magnesium, fluoride 2. Electrolytes a. Sodium, potassium, chloride 3. Enzyme-related functions a. Iron, zinc, selenium, copper
  • 9. Classification of minerals  Moderate to rigorous exercise increases the loss of some minerals 1. Mineral loss in sweat and urine may be greater in athletes 2. Adaptation to conserve some minerals as athletes acclimate to heat
  • 10. Classification of minerals  Moderate to rigorous exercise increases the loss of some minerals 3. Small to moderate losses can be offset by dietary intake 4. Larger losses may need supplementation 5. Zinc moves from muscle cells into the ECF and might be excreted in urine
  • 11. Classification of minerals  Poor food choices by athletes and sedentary people often lead to low mineral intake: 1. Athletes likely low in dietary calcium, iron, zinc, selenium, magnesium, copper 2. Energy-restricted athletes at the most risk 3. Nutrient-dense foods are important to meet overall needs 4. The best approach for determining mineral intake is personalised dietary assessment for each athlete
  • 12. Mineral deficiencies and toxicities  Mineral homeostasis 1. Generally maintained by adjusting absorption and excretion a. If storage is high, absorption decreases b. If storage is low, absorption increases 2. Hormonal and other mechanisms are also influential
  • 13. Mineral deficiencies and toxicities 1. Factors that increase mineral absorption Presence of a growth state Presence of a deficiency state Larger (vs. smaller) amounts consumed in food Presence of food in the GI tract Certain compounds in food (e.g., vitamin C, soluble fiber, MFP factor) Certain chemical forms
  • 14. Mineral deficiencies and toxicities 2. Factors that decrease mineral absorption Increasing age Poor health or GI disease Presence of competing minerals Certain compounds found in food (e.g., phytic acid, insoluble fiber) Excessive supplementation of individual minerals Presence of food in the GI tract pH of the GI tract GI transit time
  • 15.  It is important to guard against mineral deficiencies 1. General characteristics a. Deficiencies develop over time b. No signs or symptoms initially c. Signs or symptoms are non-specific when they first occur d. Specific symptoms associated with severe deficiencies Mineral deficiencies and toxicities
  • 16.  It is important to guard against mineral deficiencies 2. Prevalence of subclinical mineral deficiencies a. Iron deficiency without anemia i. Prevalence may be higher in female endurance athletes and vegetarians ii. Effect on performance not known but it is prudent to avoid this condition b. Osteopenia i. Low bone mineral density ii. May be as high as 11-22% of athletes Mineral deficiencies and toxicities
  • 17. c. It is reasonable to assume some athletes could have subclinical deficiencies of iron, calcium, zinc, selenium, and magnesium d. Subclinical deficiencies of other minerals not well documented Mineral deficiencies and toxicities
  • 18. 3. Prevalence of clinical mineral deficiencies a. Iron-deficiency anemia i. Prevalence in female athletes estimated to be 3% or more ii. Prevalence in male athletes very low but not zero iii. Results in fatigue and impaired performance Mineral deficiencies and toxicities
  • 19. b. Osteoporosis i. Bone loss exacerbated with low estrogen (associated with inadequate dietary intake, low caloric intake, and low body fat) ii. 10-13% female distance runners iii. Small % of amenorrheic female distance runners < age 30 c. Clinical deficiencies negatively affect performance and health Mineral deficiencies and toxicities
  • 20.  Bone-forming minerals 1. 90% is calcium and phosphorus, used to form hydroxyapatite 2. Small amount of fluoride 3. Several minerals have indirect roles 4. Vitamin D is critical to bone development The roles of minerals in bone formation
  • 21.  Bones have both structural and metabolic functions 1. Bone growth, modeling, and remodeling The roles of minerals in bone formation Increased length and thickness during childhood and adolescence Growth is longitudinal (length) and radial (thickness) Modeling is the process in which bones are formed and shaped Mechanical stress strengthens bones Increased mineral content until approximately age 35 Slow mineral loss after approximately age 35 Accelerated mineral loss in females when estrogen production declines
  • 22. The roles of minerals in bone formation 2. Bone remodeling a. Bone turnover is constant b. Site of bone remodeling i. Cortical bone • approximately 80% of skeleton • Shafts of the long bones and on the surface
  • 23. The roles of minerals in bone formation ii. Trabecular bone • approximately 20% of skeleton • Ends of the long bones and under the surface • Honeycomb-like structure • Greater surface volume, metabolic activity, and turnover
  • 24. The roles of minerals in bone formation c. Rate and time of bone remodeling i. Rate • 1-2% of entire skeleton but approximately 20% of trabecular bone • approximately 1 million active sites each day ii. Length of time • In children, weeks • In young adults, approximately 3 months • In older adults, approximately 6 to 18 months • Over a ten-year timeframe an adult’s skeleton will be completely remodeled
  • 25. d. Osteoclasts resorb bone i. Stimulated by physical activity and microfractures ii. Stimulated by hormones—PTH and calcitriol e. Osteoclast/osteoblast balance i. In children and adolescents, deposition is favored ii. In young adults, balance generally exists iii. In middle-aged to older adults, resorption is favored (more osteoclastic activity) The roles of minerals in bone formation
  • 26.  Achieving peak bone mineral density is critical to long-term health 1. Highest lifetime bone mineral density a. Trabecular bone by approximately age 30 b. Cortical bone by approximately age 35 2. Approximately 60% is genetically determined 3. Important influences a. Adequate calcium, vitamin D, and protein intakes b. Weight-bearing exercise or activity or high- impact exercise (jumping, strength training) c. Hormones The roles of minerals in bone formation
  • 27. 4. Nutritional factors affecting peak bone density a. Calcium i. Greatest amount needed for ages 9 to 18 (1,300 mg/day) ii. Substantial need throughout adulthood (1,000 to 1,200 mg/day) b. Vitamin D i. 5 mcg/day until age 50 ii. Need increases with age • 10 mcg ages 51 to 69; 15 mcg age 70 and above • Conversion to active form declines • Exposure to UV light declines The roles of minerals in bone formation
  • 28. c. Protein i. Adequate protein in children is associated with bone growth ii. Necessary for secretion of IGF-1 5. Mechanical factors affecting peak bone density a. Weight-bearing exercise b. High-impact activities c. Excess body weight The roles of minerals in bone formation
  • 29. 5. Bone loss associated with aging The roles of minerals in bone formation In women, 0.25 to 1.0% yearly until age 50 With estrogen deficiency, 1-2% yearly (mainly from vertebrae) In the decade after menopause, 20-30% of bone density from trabecular bone and 5-10% from cortical bone In older men, approximately 1% yearly Bone loss associated with low calcium availability for functional use and to maintain calcium homeostasis Under hormonal regulation Normal calcium excretion is approximately300 mg between GI secretions and urine losses
  • 30. The roles of minerals in bone formation 6. Calcium may be taken from bone to maintain calcium homeostasis a. Hormonally controlled i. Parathyroid hormone (PTH) ii. Calcitriol (form of vitamin D)
  • 31. The roles of minerals in bone formation b. Calcium homeostasis i. Regulation of calcium in the blood and extracellular fluid ii. Primarily controlled by PTH iii. Critical for proper nerve and muscle function iv. Fast calcium exchange • PTH activates calcium pumps in membranes surrounding bone fluid • Calcium is mobilized from bone fluid not mineralized bone • PTH stimulates calcium resorption in kidney and increased GI absorption
  • 32. 3. Calcium balance a. Total absorption, distribution, and excretion b. Different from calcium homeostasis but related c. Increased or decreased absorption and excretion as needed d. Bone turnover is balanced under normal conditions The roles of minerals in bone formation
  • 33. 4. Long-term low calcium intake a. Bone turnover is not balanced b. Slow calcium exchange i. PTH stimulates dissolution of bone ii. Increases osteoclastic activity; decreases osteoblastic activity iii. Calcium (and phosphate) released from bone iv. Over time, integrity of bone is decreased The roles of minerals in bone formation
  • 34.  Bone loss is associated with lack of estrogen The roles of minerals in bone formation Powerful influence on osteoclast number and activity Generally associated with menopause Also present in some young female athletes Distance runners, ballerinas, and gymnasts are at greater risk Focus on research: Does the Disruption of the Menstrual Cycle That Occurs in Some Athletes Have Health Implications?
  • 35.  The roles of calcium and exercise in preventing or reducing bone loss associated with aging have not been fully established 1. Diet-related a. In women after age 70, calcium supplementation is beneficial b. Calcium supplementation after age 35 may be prudent to slow calcium losses from bones c. Calcium supplementation in this group will not offset all of the factors that affect a decline in BMD The roles of minerals in bone formation
  • 36. d. In women under 50 and most men, adequate calcium and vitamin D intakes slow the loss of bone calcium e. In the first 10 years after menopause, calcium supplementation has a small, positive effect 2. Exercise-related a. High-intensity weight-bearing activities b. Resistance training c. Mechanical stress increases bone density d. Other types of exercise are beneficial but do not slow bone loss The roles of minerals in bone formation
  • 37.  There are numerous strategies for increasing dietary calcium consumption 1. Calcium sources a. Milk and milk products b. Reduced-lactose or lactase-treated milk products c. Fermented milk products d. Calcium-containing vegetables such as cabbage, broccoli, and green leafy vegetables e. Calcium-fortified foods f. Calcium supplements The roles of minerals in bone formation
  • 38. 2. Many people consume an inadequate amount of calcium daily 3. Over-consumption of calcium supplements (UL 2500 mg/day) can lead to kidney stones and displacement of other nutrients  Phosphorus, fluoride, and magnesium are also involved with bone health 1. Phosphorus is abundant in food 2. Fluoride is added to supplements or water 3. Magnesium is found in vegetables, nuts, beans, and legumes The roles of minerals in bone formation
  • 39. The roles of minerals in blood formation  Iron is an integral part of hemoglobin 1. Hemoglobin a. Iron-containing protein b. Necessary for oxygen, carbon dioxide, and nitric oxide transport c. Normal: 12.1 to 15.1 g/dl in females; 13.8 to 17.2 g/dl in males 2. Hematocrit a. Measure of oxygen-carrying capacity b. Expressed as % of total blood plasma volume c. Normal: approximately 42% in females; approximately 45% in males
  • 40. The roles of minerals in blood formation 3. Iron deficiency anemia a. Most common nutrition-related anemia b. Low iron stores may be due to: i. Poor intake ii. Poor absorption iii. Excessive blood loss
  • 41. The roles of minerals in blood formation  Blood tests can help detect iron deficiency 1. Common measures are hemoglobin, hematocrit, and ferritin 2. Iron status declines over time a. As iron stores are being depleted, hemoglobin and hematocrit do not decline initially b. Serum ferritin concentration declines 3. False (runner’s) anemia
  • 42. The roles of minerals in blood formation  Iron-deficiency anemia negatively affects performance 1. Iron-deficiency anemia impairs performance a. VO2max (aerobic capacity) declines b. Endurance capacity declines c. A decrease in iron-containing compounds decreases oxygen utilization 2. Effect of iron deficiency without anemia on performance is unclear
  • 43. The roles of minerals in blood formation  The prevalence of iron deficiency and iron-deficiency anemia in female athletes is likely higher than in the general population Unlikely in most males (<2% in males under 70 years old) Infrequently seen in adolescent males or male endurance athletes (5%) Some medications induce bleeding and loss of iron Greatest risk is for menstruating females Athletes with low caloric intake are at greater risk Sweat loss Iron loss in feces and urine in times of intensive training
  • 44. The roles of minerals in blood formation  Athletes should consume a variety of iron- containing foods 1. Adequate energy intake 2. Variety of iron-dense foods 3. Heme (animal) sources are better absorbed than nonheme (plant) sources 4. Vitamin C increases iron absorption
  • 45. The roles of minerals in the immune system  The immune system protects the body from disease 1. Immunity a. Non-specific immunity (skin, respiratory system, and GI tract) b. Specific antibodies c. Cytokines regulate the immune system
  • 46. The roles of minerals in the immune system 2. Zinc a. Widely found in cellular enzymes b. Involved in various immune functions c. Most endurance athletes (approximately90%) do not meet the RNI d. Overtraining and zinc deficiency can result in repeated URTI e. Supplementation (low dose) is appropriate when RNI isn’t met through the diet f. supplemental zinc can interfere with iron and copper absorption and decrease lymphocyte response
  • 47. The roles of minerals in the immune system 3. Selenium a. Involved in cellular and immune system function b. Found in meat, fish, poultry, whole grains, and nuts c. Depressed immunity is associated with deficiency 4. Iron a. Plays important role in immune system functions b. Excess iron impairs immune function
  • 48. The adequate intake of all minerals  The key to obtaining all the minerals needed from food is to consume a nutrient-dense, whole-foods diet A varied, nutrient- dense diet can provide adequate amounts of minerals High-sugar/high-fat diets often do not meet daily mineral requirements Consume an adequate amount of calcium and iron from food
  • 49. The adequate intake of all minerals  The dose and potency of a mineral supplement can vary substantially from brand to brand 1. Mineral-fortified foods a. Some foods have many minerals added b. Degree of absorption is unknown 2. Multimineral supplements a. Dosages may exceed the RNI or UL for some nutrients b. Degree of absorption is not known
  • 50. The adequate intake of all minerals 3. Supplementing with individual minerals a. Calcium and iron are most common b. Should be physician prescribed, not self prescribed c. Likely to affect absorption of other minerals d. High bioavailability may not be desirable
  • 51. The adequate intake of all minerals 4. Spotlight on supplements: How Beneficial is Chromium Supplementation for Athletes? a. Some may contain highly absorbable form b. Enhances insulin sensitivity c. Effectiveness for increasing muscle mass and decreasing body fat unclear
  • 52.  4 minerals critical for bone formation:  3 major electrolytes:  3 trace elements that may be lost in sweat or urine:  4 food components that inhibit mineral absorption:  2 types of cells involved in skeletal growth:  2 hormones that regulate calcium balance:  3 serum values used to evaluate iron status:  3 rich food sources of copper: