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hey buddy, can you spare
        a $100 million?
               or
        how to convince
successful financiers to give you
 millions of dollars in a project
         doomed to fail!

                         Michael Polonsky
                          April 15th, 2009
I love love love
entrepreneurs   innovation   canada
General Petraeus on powerpoint


quot;It's how you communicate big ideas - to communicate them effectively.quot;
?
what is a presentation
general   specific
The closest cousin to
 a power point slide 
is a billboard!
But you’ve got a lot to say …

    350 employees                 logo                   VC shareholders

   75 key accounts           Track record                    Website

    Business plan        Chief financial officer        Audited statements

     Momentum                  Strengths              Something big coming

 Overcome obstacles          Opportunities               Media coverage

  95,000 square feet         Expert board                Revenue model

      8 products                Awards                     Acquisitions

Competitive advantages     Growth strategy               Nice boardroom

       Mission           Organizational chart               Technology

        Vision            Money in the bank             Intellectual property

       Values            Features and benefits     7 years of hard won memories
leave an impression
how do you encourage
                                        someone to give you $10M in
                                                        45 minutes?

On June 4 1940, Winston Churchill delivered a 45 minute speech, commonly known as “We shall fight
on the beaches”, to the House of Commons of the British Parliament. It was a great inspiration to an
embattled United Kingdom as it entered what was probably the most vulnerable phase of the entire war.
Public opinion for the war effort was waning in the face of devastating losses and a formidable enemy.
Churchill encouraged a country to keep fighting in 45 minutes.
general   specific
tip (not rule) no. 1




      keep it high level
                           don’t DROWN in DETAIL
      keep it clean
?
what is a presentation
You got 45 minutes: on you mark, get set, go …

    350 employees                 logo                   VC shareholders

   75 key accounts           Track record                    Website

    Business plan        Chief financial officer        Audited statements

     Momentum                  Strengths              Something big coming

 Overcome obstacles          Opportunities               Media coverage

  95,000 square feet         Expert board                Revenue model

      8 products                Awards                     Acquisitions

Competitive advantages     Growth strategy               Nice boardroom

       Mission           Organizational chart               Technology

        Vision            Money in the bank             Intellectual property

       Values            Features and benefits     7 years of hard won memories
You actually only get 23 minutes.
Marathon   100 metres
huh                      aha
         NOW!




      (rapid transfer)
points
NOT all



      are created equal
All points are equal
•    Interesting point but not really relevant
•    Uninteresting point but relevant
•    Major, earth shattering, earth quaking point
•    Interesting corollary perspective
•    Necessary background point
•    Interesting-but-dude-is-now-sleeping point
•    Because-I-love-the-sound-of-my-voice point
The point
            additional support
Big big
big         additional support

support
            additional support
The point

Big big         additional support


big
support         additional support




Underlying takeaway message
The point

  A         B          C




Underlying takeaway message
The point

  A         B          C



  1          2         3

Underlying takeaway message
/
1
 3
      of all
      new
      products




The future of medicine

                         25
Outlook:
Revenue growth
of 10 to15 percent
in fiscal 2008


                     26
Cangene is fully integrated


                Develop
              from concept to commercialization

                Manufacture
              process sensitive biopharmaceuticals

                Sell
              niche marketing team for biodefense
              products and commercial partnerships
Strong preclinical franchise                      28




  Top 10
  Preclinical CRO worldwide


  400+
  Active clients

                              A fast growing,
  90%
                              highly profitable
  Retention rate


                              CRO
  8 of 10
  Largest pharma as clients
Molybdenum




12B
                 *
                      Strengthens steel


$
annual market        Anti-corrosive agent




                      Chemical catalyst


                                                      29
                             MERCATOR MINERALS LTD.
*Add note here
tip (not rule) no. 2




   think about emphasis
   think about scale
                            GRID it to GREAT
   think about priorities
maps
pictures
diagrams
                Not words
illustrations
?
what is a presentation
•  afj;psldk   •  afj;psldk   •  afj;psldk      •  afj;psldk   •  afj;psldk   •  afj;psldk
•  aslkdflfk   •  aslkdflfk   •  aslkdflfk      •  aslkdflfk   •  aslkdflfk   •  aslkdflfk
•  asljkfhf    •  asljkfhf    •  asljkfhf       •  asljkfhf    •  asljkfhf    •  asljkfhf




•  afj;psldk   •  afj;psldk   •  afj;psldk      •  afj;psldk   •  afj;psldk   •  afj;psldk
•  aslkdflfk   •  aslkdflfk   •  aslkdflfk      •  aslkdflfk   •  aslkdflfk   •  aslkdflfk
•  asljkfhf    •  asljkfhf    •  asljkfhf       •  asljkfhf    •  asljkfhf    •  asljkfhf




•  afj;psldk   •  afj;psldk   •  afj;psldk      •  afj;psldk   •  afj;psldk   •  afj;psldk
•  aslkdflfk   •  aslkdflfk   •  aslkdflfk      •  aslkdflfk   •  aslkdflfk   •  aslkdflfk
•  asljkfhf    •  asljkfhf    •  asljkfhf       •  asljkfhf    •  asljkfhf    •  asljkfhf




•  afj;psldk   •  afj;psldk   •  afj;psldk      •  afj;psldk   •  afj;psldk   •  afj;psldk
•  aslkdflfk   •  aslkdflfk   •  aslkdflfk      •  aslkdflfk   •  aslkdflfk   •  aslkdflfk
•  asljkfhf    •  asljkfhf    •  asljkfhf       •  asljkfhf    •  asljkfhf    •  asljkfhf




•  afj;psldk   •  afj;psldk   •  afj;psldk      •  afj;psldk   •  afj;psldk   •  afj;psldk
•  aslkdflfk   •  aslkdflfk   •  aslkdflfk      •  aslkdflfk   •  aslkdflfk   •  aslkdflfk
•  asljkfhf    •  asljkfhf    •  asljkfhf       •  asljkfhf    •  asljkfhf    •  asljkfhf




                                        20-30 slides
the great ones are more than a series of slides
power of a narrative
?
what is a presentation




       1
       story
which came first?
hunger
no hunger … no plot … no one cares
Coronary Heart Disease




one
Number


                         20%
killer!                  of all deaths
BREAKING THROUGH



Wet AMD
Insulin
Meeting the Emerging Exploding Demand
What if there wasn’t
enough insulin?
What if there wasn’t
enough insulin?
There isn’t.
50% of potential wind energy is lost
                                       44




   59.3%
 Maximum
theoretical
 efficiency
(Betz limit)




25 - 30%
     Actual
 efficiency




          0
Because the wind is always shifting, turbines
are almost always misaligned…
                                                                                        45
                                                                                        45



    Optimal alignment                     Actual misalignment in operation

                                                                    LOST
                                                                 EFFICIENCY




                        energy produced




                                                                      energy produced
   wind
                                                           Yaw
…and because the wind is always gusting,
the blades are almost always mis-pitched
                                                                                     46




      Optimal pitch                     Actual mis-pitch in operation

                                                               LOST
 MORE ENERGY
                                                            EFFICIENCY
                                         LOST ENERGY
  CAPTURED




                      energy produced




                                                                   energy produced
value proposition

      Solution to hunger
Neuradiab Survival Data

Clinically compelling difference

                                                   42         %

                                                                        91
            Surgery + Radiation + Temozolomide + Neuradiab
                                                                        weeks

                                                           64
 2005       Surgery + Radiation + Temozolomide
                                                           weeks

 1980
                                             53
            Surgery + Radiation
   to
                                             weeks
 2004



        0           15            30         45             60     75       90   105


                                       Survival in weeks                          48
CRD5 Rapidly Increases HDL
% increase in HDL




                    CRD5                       Niacin - ER
                    Levels still rising
                                               Poorly tolerated
                    Non-optimized
                                               Low market share
                    formulation
                    Healthy volunteers



                                    Crestor
                                    (Statin)
Expanding Clinical Benefit

                   Frontline                      Watchful waiting

                                                         OvaRex® MAb extends
                                                            time to relapse

                                                                 13
                                                                 months
Tumor                                                                     Relapse
Burden                                                                    diagnosed
 CA 125
  Level
                               Initiate OvaRex®
                               MAb therapy




    Months 0                   6                       16                       30
                   Surgery
                                   No drugs approved
                   chemo
                                                                          OvaRex MAb   10
(Source: OGY 07)
complete responses

four doses of Proxinium™         complete tumor response




              25%          complete responses
FunctionFIRST™ yields results




                                   Five
     A pipeline of


     500                         lead candidates

       antibodies




52
52
We can make wind energy
production more efficient!
                                  53




 Possible
efficiency




                    Improvement
                    with our
    Actual
                    technology!
efficiency




        0
greedno one invests in hyper growth
             stories to double their money



you have to show them the 10 bagger
                        - Michael Denny
ISA247 Psoriasis Opportunity


                                        if at $5,000 = $692,500,000
                25%                     per treatment cycle

                                        if at $10,000 = $1,385,000,000
                  market share
                                        per treatment cycle




                                                              ISA247:
                            554,000                           Established
                                                              safety and
                           patients treated with oral
                                immunosuppressants
                                          in the U.S.
                                                              efficacy

55   Source: Datamonitor
World’s Largest Drug Market

Top 3 drug categories
                                  $30.2B




                                                   5 drugs over
                  $25.5B

                                                 $ 1billion+
   $23.8B




  Cytostactics                   Cholesterol 
                 Antiulcerants
   (Cancer)                       triglyceride
                   (GI tract)
                                    reducers
Our potential
                                                                             57




                                                        +
             Wind turbine opportunity


Expanded operating envelope

         Reduced downtime

     Improved speed control


                                        $11
             Reduced wear
                                                    Met tower replacement
              Pitch benefit
               Yaw benefit
                                        Billion     Airports

                                                    Yacht/sailboats

                                                    Forest fire fighting

                                                    National wind map
$8B
                Spent annually in
                North America
                expanding  replacing
                current infrastructure


Resin Systems                      58
need expressed:    hunger

need addressed:    value proposition

market opportunity: greed
tip (not rule) no. 3




                           don’t come up flat
   think about structure
brevity
patterns
stories
           Not blind faith
emotion
Complexity/quantity     Time constraints        Durable goals




  right information     rapidly transferred   High impact/recall




                          grid it to great     don’t come up flat
don’t drown in detail
the
distilled                              not
                 right information
messages                               everything



maps
pictures
diagrams                               not
                 rapidly transferred
illustrations                          words




brevity
patterns        with
stories                                not
                 high recall
emotion                                blind faith
don’t forget

milestones

request for cash

current shareholders

financings to date

IP
Milestones



SPY System                                         Q3 2005   Q4 2005   Q1 2006

U.S. sales partner                                   X

Installed in 25 U.S. hospitals                                  X

Initiate studies for expanded indications                       X



OPTTX System
Initiate North American multi-centre trial                      X

Initiate combo trial with multi-national partner                X

File for Canadian and European approval                                   X
Exendin-4 Albumin Conjugate: Next Steps
(PC-DAC™:Exendin-4)


One month multi-dose Phase I/II trial
Investment Opportunity



    Seeking              –  Launching
                            commercial platform

   $15million            –  Expanding content
                            partnerships
    in financing
                         –  Developing
    to drive the            molecular tests
    business             –  Scaling quality
    forward                 manufacturing
recommended reading




   made to stick

    brain rules

    slideology
closing thoughts
evidence evidence evidence
be authentic!




      STOP            TALK       …transacts!
                                   generating
       the bullshit   like a   person
                                   earned
                                   attributes
how do you get to Carnegie Hall?
speed dating




     show a
  little leg …   … move on
dilution




  100%
                           Think



                         big!!!
       of zero is zero
thank you

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Building a Pitch

  • 1.
  • 2. hey buddy, can you spare a $100 million? or how to convince successful financiers to give you millions of dollars in a project doomed to fail! Michael Polonsky April 15th, 2009
  • 3. I love love love entrepreneurs innovation canada
  • 4. General Petraeus on powerpoint quot;It's how you communicate big ideas - to communicate them effectively.quot;
  • 5. ? what is a presentation
  • 6.
  • 7. general specific
  • 8. The closest cousin to a power point slide is a billboard!
  • 9. But you’ve got a lot to say … 350 employees logo VC shareholders 75 key accounts Track record Website Business plan Chief financial officer Audited statements Momentum Strengths Something big coming Overcome obstacles Opportunities Media coverage 95,000 square feet Expert board Revenue model 8 products Awards Acquisitions Competitive advantages Growth strategy Nice boardroom Mission Organizational chart Technology Vision Money in the bank Intellectual property Values Features and benefits 7 years of hard won memories
  • 11. how do you encourage someone to give you $10M in 45 minutes? On June 4 1940, Winston Churchill delivered a 45 minute speech, commonly known as “We shall fight on the beaches”, to the House of Commons of the British Parliament. It was a great inspiration to an embattled United Kingdom as it entered what was probably the most vulnerable phase of the entire war. Public opinion for the war effort was waning in the face of devastating losses and a formidable enemy. Churchill encouraged a country to keep fighting in 45 minutes.
  • 12. general specific
  • 13. tip (not rule) no. 1 keep it high level don’t DROWN in DETAIL keep it clean
  • 14. ? what is a presentation
  • 15. You got 45 minutes: on you mark, get set, go … 350 employees logo VC shareholders 75 key accounts Track record Website Business plan Chief financial officer Audited statements Momentum Strengths Something big coming Overcome obstacles Opportunities Media coverage 95,000 square feet Expert board Revenue model 8 products Awards Acquisitions Competitive advantages Growth strategy Nice boardroom Mission Organizational chart Technology Vision Money in the bank Intellectual property Values Features and benefits 7 years of hard won memories
  • 16. You actually only get 23 minutes.
  • 17. Marathon 100 metres
  • 18. huh aha NOW! (rapid transfer)
  • 19. points NOT all are created equal
  • 20. All points are equal •  Interesting point but not really relevant •  Uninteresting point but relevant •  Major, earth shattering, earth quaking point •  Interesting corollary perspective •  Necessary background point •  Interesting-but-dude-is-now-sleeping point •  Because-I-love-the-sound-of-my-voice point
  • 21. The point additional support Big big big additional support support additional support
  • 22. The point Big big additional support big support additional support Underlying takeaway message
  • 23. The point A B C Underlying takeaway message
  • 24. The point A B C 1 2 3 Underlying takeaway message
  • 25. / 1 3 of all new products The future of medicine 25
  • 26. Outlook: Revenue growth of 10 to15 percent in fiscal 2008 26
  • 27. Cangene is fully integrated   Develop from concept to commercialization   Manufacture process sensitive biopharmaceuticals   Sell niche marketing team for biodefense products and commercial partnerships
  • 28. Strong preclinical franchise 28 Top 10 Preclinical CRO worldwide 400+ Active clients A fast growing, 90% highly profitable Retention rate CRO 8 of 10 Largest pharma as clients
  • 29. Molybdenum 12B * Strengthens steel $ annual market Anti-corrosive agent Chemical catalyst 29 MERCATOR MINERALS LTD. *Add note here
  • 30. tip (not rule) no. 2 think about emphasis think about scale GRID it to GREAT think about priorities
  • 31. maps pictures diagrams Not words illustrations
  • 32. ? what is a presentation
  • 33. •  afj;psldk •  afj;psldk •  afj;psldk •  afj;psldk •  afj;psldk •  afj;psldk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  asljkfhf •  asljkfhf •  asljkfhf •  asljkfhf •  asljkfhf •  asljkfhf •  afj;psldk •  afj;psldk •  afj;psldk •  afj;psldk •  afj;psldk •  afj;psldk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  asljkfhf •  asljkfhf •  asljkfhf •  asljkfhf •  asljkfhf •  asljkfhf •  afj;psldk •  afj;psldk •  afj;psldk •  afj;psldk •  afj;psldk •  afj;psldk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  asljkfhf •  asljkfhf •  asljkfhf •  asljkfhf •  asljkfhf •  asljkfhf •  afj;psldk •  afj;psldk •  afj;psldk •  afj;psldk •  afj;psldk •  afj;psldk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  asljkfhf •  asljkfhf •  asljkfhf •  asljkfhf •  asljkfhf •  asljkfhf •  afj;psldk •  afj;psldk •  afj;psldk •  afj;psldk •  afj;psldk •  afj;psldk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  aslkdflfk •  asljkfhf •  asljkfhf •  asljkfhf •  asljkfhf •  asljkfhf •  asljkfhf 20-30 slides
  • 34. the great ones are more than a series of slides
  • 35. power of a narrative
  • 36. ? what is a presentation 1 story
  • 38. hunger no hunger … no plot … no one cares
  • 39. Coronary Heart Disease one Number 20% killer! of all deaths
  • 41. Insulin Meeting the Emerging Exploding Demand
  • 42. What if there wasn’t enough insulin?
  • 43. What if there wasn’t enough insulin? There isn’t.
  • 44. 50% of potential wind energy is lost 44 59.3% Maximum theoretical efficiency (Betz limit) 25 - 30% Actual efficiency 0
  • 45. Because the wind is always shifting, turbines are almost always misaligned… 45 45 Optimal alignment Actual misalignment in operation LOST EFFICIENCY energy produced energy produced wind Yaw
  • 46. …and because the wind is always gusting, the blades are almost always mis-pitched 46 Optimal pitch Actual mis-pitch in operation LOST MORE ENERGY EFFICIENCY LOST ENERGY CAPTURED energy produced energy produced
  • 47. value proposition Solution to hunger
  • 48. Neuradiab Survival Data Clinically compelling difference 42 % 91 Surgery + Radiation + Temozolomide + Neuradiab weeks 64 2005 Surgery + Radiation + Temozolomide weeks 1980 53 Surgery + Radiation to weeks 2004 0 15 30 45 60 75 90 105 Survival in weeks 48
  • 49. CRD5 Rapidly Increases HDL % increase in HDL CRD5 Niacin - ER Levels still rising Poorly tolerated Non-optimized Low market share formulation Healthy volunteers Crestor (Statin)
  • 50. Expanding Clinical Benefit Frontline Watchful waiting OvaRex® MAb extends time to relapse 13 months Tumor Relapse Burden diagnosed CA 125 Level Initiate OvaRex® MAb therapy Months 0 6 16 30 Surgery No drugs approved chemo OvaRex MAb 10 (Source: OGY 07)
  • 51. complete responses four doses of Proxinium™ complete tumor response 25% complete responses
  • 52. FunctionFIRST™ yields results Five A pipeline of 500 lead candidates antibodies 52 52
  • 53. We can make wind energy production more efficient! 53 Possible efficiency Improvement with our Actual technology! efficiency 0
  • 54. greedno one invests in hyper growth stories to double their money you have to show them the 10 bagger - Michael Denny
  • 55. ISA247 Psoriasis Opportunity if at $5,000 = $692,500,000 25% per treatment cycle if at $10,000 = $1,385,000,000 market share per treatment cycle ISA247: 554,000 Established safety and patients treated with oral immunosuppressants in the U.S. efficacy 55 Source: Datamonitor
  • 56. World’s Largest Drug Market Top 3 drug categories $30.2B 5 drugs over $25.5B $ 1billion+ $23.8B Cytostactics Cholesterol Antiulcerants (Cancer) triglyceride (GI tract) reducers
  • 57. Our potential 57 + Wind turbine opportunity Expanded operating envelope Reduced downtime Improved speed control $11 Reduced wear   Met tower replacement Pitch benefit Yaw benefit Billion   Airports   Yacht/sailboats   Forest fire fighting   National wind map
  • 58. $8B Spent annually in North America expanding replacing current infrastructure Resin Systems 58
  • 59. need expressed: hunger need addressed: value proposition market opportunity: greed
  • 60. tip (not rule) no. 3 don’t come up flat think about structure
  • 61. brevity patterns stories Not blind faith emotion
  • 62. Complexity/quantity Time constraints Durable goals right information rapidly transferred High impact/recall grid it to great don’t come up flat don’t drown in detail
  • 63. the distilled not right information messages everything maps pictures diagrams not rapidly transferred illustrations words brevity patterns with stories not high recall emotion blind faith
  • 64. don’t forget milestones request for cash current shareholders financings to date IP
  • 65. Milestones SPY System Q3 2005 Q4 2005 Q1 2006 U.S. sales partner X Installed in 25 U.S. hospitals X Initiate studies for expanded indications X OPTTX System Initiate North American multi-centre trial X Initiate combo trial with multi-national partner X File for Canadian and European approval X
  • 66. Exendin-4 Albumin Conjugate: Next Steps (PC-DAC™:Exendin-4) One month multi-dose Phase I/II trial
  • 67. Investment Opportunity Seeking –  Launching commercial platform $15million –  Expanding content partnerships in financing –  Developing to drive the molecular tests business –  Scaling quality forward manufacturing
  • 68. recommended reading made to stick brain rules slideology
  • 71. be authentic! STOP TALK …transacts! generating the bullshit like a person earned attributes
  • 72. how do you get to Carnegie Hall?
  • 73. speed dating show a little leg … … move on
  • 74. dilution 100% Think big!!! of zero is zero