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Role of stat3 protein & thelper 17 cell in psoriasis development by yousry
- 3. Cytokines and growth factors that activate STAT proteins
- 9. Regulation of the STAT3 signal transduction pathway
- 10. Regulation of intracellular Stat3 signalling .
- 11. Effects of STAT3 Deficiency on Cellular Function Stuart et al.T he Journal of Immunology, 2009, 182: 21–28
- 12. Psoriasis
- 15. Psoriasis as an immune disorder
- 22. T HELPER(TH) CELL DEVELOPMENT&DIFFERENTIATION: A BACKGROUND
- 26. The Th1-Th2 Paradigm Naive T cell Dendritic cell TGF IFN IL-4 +IL-6 -IL-6 Th1 Tbet Th2 Gata 3 Th17 ROR T aTreg FoxP3 IL-12R IL-12 IL-23R IL-23 Adapted from Reiner et al., Cell , 2007 Autoimmunity Inflammation Cancer Extracellular bacteria Allergy and asthma Systemic pathology Harmful role Counter regulation Parasitic worms Intracellular pathogens Protective role
- 27. The Fate of Immune Responses Depends on the Balance between Effector and Regulatory T cells T regulatory T effector
- 28. Features of T Helper Subsets
- 29. STAT3 & TH17 CELL
- 31. STAT3 & Th17/Treg developmental programs
- 32. T helper cell precursors being skewed towards Th1, Th2, Th17 and T regulatory cell (Treg) phenotypes on the basis of the cytokine environment .
- 41. Proinflammatory Effects of IL17
- 42. Roles of IL-23 on T helper 17 cells in Chronic Inflammation Adapted from Iwakura & Ishigame, J Clin Invest 116:1218-1222 (2006) Dendritic cell Macrophage IL-23 IL-12 Th1 Th17 IFN IL-1, IL-6 TNF Inflammatory response Endothelial cells Stromal cells Epithelial cells Fibroblasts Macrophage IL-17, IL-6 IL-1 IL-6 IL-8 TNF IL-12R IL-23R IL-23R
- 43. T Helper 17 Activation Mechanisms in Psoriasis
- 47. New Informations
- 50. Studies on Stat 3 in Psoriasis
- 51. Stat 3 in Psoriasis
- 57. Therapeutic Targets in Psoriasis As a T Helper 17 Cell Disease
- 61. Message Home
- 64. THANK YOU