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Maternal 
                                M t      l
                                mortality:
                             evidence gaps & 
                              measurement 
                                  traps

  Professor Wendy J Graham


New approaches to maternal mortality in Africa
N           h             l        li i Af i
   University of Cambridge: July 2‐3rd 2012
Millennium Development Goal 5a is off‐target*  globally

                                           450

                                           400    X
          deaths per 100 000 live births




                                           350

                                           300

                                           250

                                           200

                                           150
 Maternal d




                                           100                               MM Target
                                                  X
                                            50

                                             0
                                                 1990   1995   2000   2005   2010        2015

* 75% reduction in the maternal mortality ratio between 1990 and 2015.       
Source: UN, May 2012
Can the maternal health knowledge
community do better in what we do 
      and the way we do it?
      and the way we do it?
Knowledge 
                            Knowledge actors
                            Knowledge actors
Community

                   Identify knowledge gaps

                             Measurement 
                                 traps*: 
                                concepts, 
                                concepts          Gather & 
                                                  Gather &
 Translate &                  definitions,     synthesize new 
communicate                    indicators,       knowledge 
                                                 knowledge
                             sources, tools


Knowledge actors                               Knowledge actors


* Graham & Campbell, 1992
Provocation 1:
        Provocation 1:

How should we define & measure 
          “success”?
Nigeria: maternal mortality trends 1985‐2011 
                    using UN & IHME* estimates
             1400
             1200                              2015 target: MMR 275
             1000
        M 800
        M
          600
        R
          400
                                                2015 target: MMR 100
               200
                   0
                            1985          1990           1995          2000    2005    2008      2010      2011
                                                                           Year

                                 UN 2010               IHME 2010           IHME 2011       UN 2012


Notes: UN 2012means estimates for year 2010 published 2012 
IHME 2008 means estimates for year 2008 published by Hogan et al (2010)
                                                                                  * Institute of Health Metrics & 
IHME 2011 means estimates for year 2011 published by Lozano et al (2011)          Evaluation, University of Washington
Hindustan Times, August 20th 20 0
 i d       i            20 2010
Dipping‐in &‐out of the health system: Nigeria (2008)
   100 %
    90
    80
    70
    60
    50
    40
    30
    20
    10
     0




                                                                                                                                                     DPT 1 dose




                                                                                                                                                                                                                 Met need
                                                                        C 4/4+ visits


                                                                                        SAD




                                                                                                                         Postnatal visit




                                                                                                                                                                                         Contraceptive use
                                                                                                                                           feeding




                                                                                                                                                                      Full Vaccine
              ANC 1 visit


                               natal Tetnus




                                                                                                         al deliveries
                                              2+ Tetanus Injections




                                                                                                                                            Breast




                                                                                                                                                                      F
                                                                                              Institutiona
                                                                      ANC
                            Neon




                                                                                                                                           Poorest                2                  3                       4       Richest
Source: Immpact analysis of DHS data; Graham & Fitzmaurice, 2011 
– most recent birth only
The age of accountability
         The age of accountability

 “ In considering society’s expectations & our own 
 “         d             ’               &
goals {ask knowledge actors}, we believe that there 
 is a moral imperative to reconsider how scientific 
           l                      d h           f
              data are judged & used.”


             Young et al.  PLoS Med 2008; e201
             Y      t l PL S M d 2008 201
“If our objective is to learn, then failure 
     “If      bj i i         l       h f il
 represents an immense opportunity, and if our 
    aim is to seize the greatest opportunities 
    available to us, then we need to become 
    available to us, then we need to become
             connoisseurs of failure...

What is a great failure is a project in pursuit of a 
    noble goal... It is one we learn from.”
        bl     l I i            l      f    ”


                  Gunderman, RD. (2010)
Provocation 2:
 Provocation 2:

Do we ever learn?
Copyright North of Scotland Health Service Archive
Copyright North of Scotland Health Service Archive
MATERNAL MORTALITY: United Kingdom
                              g

                                         900
                                    ve
                            0,000 liv



                                         800                    “Maternal mortality is a great blot 
                                         700                    on public health administration.” 
 M atern al D eath s p er 100




                                         600                    Minister of Health, 1935
                b irt s




                                         500
                    th




                                         400
                                         300
                                         200
                                         100
   a




                                          0
                                           1850   1870   1890      1910   1930   1950   1970   1990   2010
                                                                          Year
Do we ever learn?
           Do we ever learn?


           Two current “blind spots”: 
                       “bli d      ”

1. Skilled a endant at birth ≠ skilled care at birth

 2. High coverage is necessary but not sufficient
Skilled Care at Birth: the complete “package”
 Community
                     Enabling environment e.g. supplies, 
                             g                g pp ,
                     infrastructure, transport, etc  

                             Skilled attendants


          Skills to promote           Referral
                                                          Skills to provide 
                                                                    p
        utilisation of delivery                           comprehensive  
         care and to conduct                                emergency 
          normal deliveries                                obstetric care

                                   Skills to provide basic 
                                   emergency obstetric 
                                   emergency obstetric
                                             care
Percentage of deliveries with skilled 
attendants 2008
attendants* 2008




        <25%
      25‐49%
      25 49%
      50‐74%
      75‐94%
        >95%
      No data


*Defined as health professionals (doctors, midwives, 
nurses). Data source: WHO (2008), WRA Birth Atlas 2010
“Higher coverage is critical but
  Higher coverage is critical but 
saving lives also depends on the 
     g               p
         quality of care.”  


  Taking stock of maternal, newborn and child survival: 2000‐2010 
                 Decade Report. Executive Summary
                 Decade Report Executive Summary
                   Countdown to 2015.  June 2010
Provocation 3:
          Provocation 3:

Are we responsive to changing needs 
           and demands?
             dd       d?
A dynamic burden: medical causes of 
           y
         maternal deaths, Bangladesh 2010
                                     Eclampsia
                                        20%
         Hemorrhage
            31%                                  Obstructed 
                                                 Prolonged 
                                                   Labor
                                                    7%
                                                     Abortion
                                                       1%
                                                   Other Direct
                                                       5%
   Undetermined
        1%




                                   Indirect
                                     35%

Source: BMMS 2010 Summary report
Collectively, NCDs are the 
leading cause of death for 
women worldwide. They 
cause 65% of all female 
deaths, amounting to 18 
million deaths each year. 

No longer diseases of the rich 
and elderly, NCDs are a 
significant cause of female 
death during childbearing 
years and for women with 
young families in developing 
countries
Global Strategy for Women s & Children s Health ?
             Global Strategy for Women’s & Children’s Health ?

    • Country‐led health plans
            y            p
    • Comprehensive package of essential interventions and 
      services
    • Integrated care
    • Health systems strengthening
    • Health workforce capability building
    • Coordinated research and innovation
    • Accountability at all levels
      Accountability at all levels

http://www.who.int/pmnch/activities/jointactionplan/en/index.html
“Maternal mortality is much more
 Maternal mortality is much more 
      than a medical issue
      than a medical issue”

             Ban Ki‐moon
    United Nations Secretary General
    U it d N ti    S    t G        l
                 2009
Knowledge  stakeholders are diverse


                                                     Private sector
                                      Media

 Funding        Research                           Think              Government 
 bodies         institutions                       tanks              bodies


                               Advocates, civil 
                               Advocates, civil
                               society, NGOs, 
                               parliamentarians




Adapted from: Alliance for Health Policy and Systems Research. 2007.
“There is nothing {we} like so little as 
to be well informed; it makes decision‐
t b      ll i f   d it     k d ii
   making so complex and difficult.
   making so complex and difficult.”


               J M Keynes  
               J M Keynes
              (1883‐1946)
“Policy‐makers 
                                are from Mars.
                                Researchers are 
                                 from Venus.”*




*Adapted from John Gray, 2004
“The role of the scientist is to use research to ascertain
  The role of the scientist is to use research to ascertain 
 the effectiveness of innovative policies and programs. 

This is in contrast to {their} role as advisor in which the 
        scientist can indulge in over advocacy ...
        scientist can indulge in over‐advocacy ”.



          Donald T Campbell 1988 The experimenting society.
Can the maternal health knowledge
community do better in what we do 
      and the way we do it?
      and the way we do it?

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Wendy J Graham: New Approaches to Maternal Mortality In Africa