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Mastitis:
A Reaction of the Immune System
RJ Erskine
Michigan State University
Mastitis
Intramammary Infections
•Infectious microbes
• Primarily bacteria
–Mycotic, algae
•Teat end exposure,
invasion
Infection induces inflammation
•Heat
•Pain
•Swelling
•Edema
•Leukocytosis
Somatic Cell Counts
Inflammation:
Cytokines
Phagocytes in the mammary gland
• Low numbers (< 100 X of blood)
• Target fat, protein
• • Lactose …Not glucose (no energy)
• Lower antibodies, opsonins
Fat
Protein
S. aureus
Primary Mammary Immunity
Hyperkeratosis
Clean, Dry, Comfortable Cows
Never forget, this is about food

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Mastitis: A Reaction of the Immune System- Ron Erskine