The document provides guidance on creating effective essential questions to guide research. It explains that essential questions should be open-ended, meaningful to the researcher, and aim to develop higher-level thinking skills like analysis, synthesis and evaluation rather than just comprehension. Some tips are considering what is already known, making sure the question isn't something that can be easily answered, and testing questions using a "Plus, Minus, Interesting" table. Effective questions cues include words like "explain", "compare", and "assess" and ask the researcher to make connections across areas of knowledge.