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HIV Vaccine Research and HIV drugs in the pipeline HIV Vaccine Research and HIV drugs in the pipeline
1. Presented by: <your name here> From Bench to Bedside An up-to-date look at HIV Vaccine Research and HIV drugs in the pipeline
2. HIV Globally 40 million infected with HIV worldwide Over 20 million have died since 1981 5 million were infected in 2004 600 new infections every hour
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7. What are the animal models for HIV vaccines? Macaques Chimpanzees
8. What types of HIV vaccines are being tested? Peptide epitopes (protein fragments) Status: In phase I trials Live attenuated HIV Status: Non-human primates Whole, killed HIV Status: Not under study in primates Naked DNA Status: Phase I trials
9. What types of HIV vaccines are being tested? Recombinant Viral Proteins Status: Phase II and III trials Live bacterial vectors Status: Phase I trials Live Viral Vectors Status: Phase II trials Pseudovirions Status: Pre-clinical trials
10. What are the possible HIV vaccine outcomes? Sterilizing Immunity Transient Infection Long-term controlled infection Altruistic vaccine
11. Who is organizing the HIV vaccine trial movement? “ Our goal is to develop safe and effective preventive HIV vaccines that will work everywhere on the globe, against all strains of HIV, in all people.”
12. What are some of the current HIV vaccine trials? Phase I trial- Product: AVX101 Company: Alphavax Inc. Safety of an HIV vaccine in HIV uninfected volunteers in United States and South Africa
13. What are some of the current HIV vaccine trials? Phase II Product: rgp 120 MN Company: VaxGen Study the immune system response to vaccine in Brazil, Haiti, Trinidad and Tobago
14. What are some of the current HIV vaccine trials? Phase III Products: ALVAC vCP1521/ AIDSVAX B/E Company: Aventis, VaxGen Assessing immunogenicity and ability to prevent HIV infection in Thailand
