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Presented by: <your name here> From Bench to Bedside An up-to-date look at HIV Vaccine Research and HIV drugs in the pipeline
HIV Globally 40 million infected with HIV worldwide Over 20 million have died since 1981 5 million were infected in 2004 600 new infections every hour
The World needs an HIV Vaccine ,[object Object],[object Object],[object Object]
Is an AIDS vaccine really possible? ,[object Object]
What are the steps in Vaccine development? ,[object Object],[object Object],[object Object]
Progress toward AIDS vaccine since 2000 ,[object Object],[object Object],[object Object]
What are the animal models for HIV vaccines? Macaques Chimpanzees
What types of HIV vaccines are being tested? Peptide epitopes  (protein fragments) Status: In phase I trials Live attenuated HIV Status: Non-human primates Whole, killed HIV Status: Not under study in primates Naked DNA Status: Phase I trials
What types of HIV vaccines are being tested? Recombinant Viral Proteins Status: Phase II and III trials Live bacterial vectors Status: Phase I trials Live Viral Vectors Status: Phase II trials Pseudovirions Status: Pre-clinical trials
What are the possible HIV vaccine outcomes? Sterilizing Immunity Transient Infection Long-term controlled infection Altruistic vaccine
Who is organizing the HIV vaccine trial movement? “ Our goal is to develop safe and effective preventive HIV vaccines that will work everywhere on the globe, against all strains of HIV, in all people.”
What are some of the current HIV vaccine trials? Phase I trial- Product:  AVX101 Company: Alphavax Inc. Safety of an HIV vaccine in HIV uninfected volunteers in United States and South Africa
What are some of the current HIV vaccine trials? Phase II Product: rgp 120 MN Company: VaxGen Study the immune system response to vaccine in Brazil, Haiti, Trinidad and Tobago
What are some of the current HIV vaccine trials? Phase III Products: ALVAC vCP1521/ AIDSVAX B/E Company: Aventis, VaxGen Assessing immunogenicity and ability to prevent HIV infection in Thailand
Where are these vaccines being tested?
What needs to happen to actually have an HIV vaccine?
Imagine a world without AIDS ,[object Object],[object Object]
What can you do to stay informed about HIV vaccines and HIV/AIDS? ,[object Object],[object Object],[object Object],[object Object]
Go to  www.iavi.org/callforaction and sign-on !
Sources: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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HIV Vaccine Research and HIV drugs in the pipeline HIV Vaccine Research and HIV drugs in the pipeline

  • 1. Presented by: <your name here> From Bench to Bedside An up-to-date look at HIV Vaccine Research and HIV drugs in the pipeline
  • 2. HIV Globally 40 million infected with HIV worldwide Over 20 million have died since 1981 5 million were infected in 2004 600 new infections every hour
  • 3.
  • 4.
  • 5.
  • 6.
  • 7. What are the animal models for HIV vaccines? Macaques Chimpanzees
  • 8. What types of HIV vaccines are being tested? Peptide epitopes (protein fragments) Status: In phase I trials Live attenuated HIV Status: Non-human primates Whole, killed HIV Status: Not under study in primates Naked DNA Status: Phase I trials
  • 9. What types of HIV vaccines are being tested? Recombinant Viral Proteins Status: Phase II and III trials Live bacterial vectors Status: Phase I trials Live Viral Vectors Status: Phase II trials Pseudovirions Status: Pre-clinical trials
  • 10. What are the possible HIV vaccine outcomes? Sterilizing Immunity Transient Infection Long-term controlled infection Altruistic vaccine
  • 11. Who is organizing the HIV vaccine trial movement? “ Our goal is to develop safe and effective preventive HIV vaccines that will work everywhere on the globe, against all strains of HIV, in all people.”
  • 12. What are some of the current HIV vaccine trials? Phase I trial- Product: AVX101 Company: Alphavax Inc. Safety of an HIV vaccine in HIV uninfected volunteers in United States and South Africa
  • 13. What are some of the current HIV vaccine trials? Phase II Product: rgp 120 MN Company: VaxGen Study the immune system response to vaccine in Brazil, Haiti, Trinidad and Tobago
  • 14. What are some of the current HIV vaccine trials? Phase III Products: ALVAC vCP1521/ AIDSVAX B/E Company: Aventis, VaxGen Assessing immunogenicity and ability to prevent HIV infection in Thailand
  • 15. Where are these vaccines being tested?
  • 16. What needs to happen to actually have an HIV vaccine?
  • 17.
  • 18.
  • 19. Go to www.iavi.org/callforaction and sign-on !
  • 20.