This presentation for a group of leading North American pediatricians presents the psychic effects of traumatic experiences during childhood and adolescence

2. Changelings: Children and Psychic Trauma Vincenzo Di Nicola Maisonneuve-Rosemont Hospital University of Montreal

18. Genome Development Environment Trauma Phenotype Social Support Ongoing Stress Coping Psychopathology Physiopathology (PTSD, Anxiety, Vulnerability (Immune, Metabolic, Depression, Cardiovascular) Substance Abuse) Long-Term (Mal) Adaptation

32. WHAT IS POSTTRAUMATIC STRESS DISORDER? An extreme reaction to a life stressor such as violence and trauma

47. Adverse Childhood Events and Adult Depression Adverse Events Chapman et al, 2004

48. Adverse Childhood Events and Adult Ischaemic Heart Disease Adverse Events Dong et al, 2004

49. Adverse Childhood Events and Adult Substance Abuse Self-Report: Alcoholism Self-Report: Illicit Drug Use Dube et al, 2002 Dube et al, 2005

54. What about stress and adverse experiences? What do we know about the neurobiology of these events?

59. Emotional Stimulus PIT Cortisol Cortisol CRH Amygdala Hippocampus Adrenal Cortex Hypothalamus PVN LeDoux, Synaptic Self HPA Pathway Control ACTH

65. Après la Coupe mondiale - 2006 Photo : V Di Nicola