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OPIOIDS Dr.Khalid Al-Jonaieh Demonstrator Anesthesia Department KKUH بسم الله الرحمن الرحيم
Terminology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Efficacy and Potency  ,[object Object]
ENDOGENOUS OPIOIDS AND OPIOID RECEPTORS ,[object Object],[object Object],[object Object],[object Object],[object Object]
Proenkephalin ,[object Object]
The dynorphin   ,[object Object]
Pro-opiomelanocortin ,[object Object],[object Object],[object Object]
Receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Selectivity  ,[object Object],[object Object],[object Object],[object Object]
Cellular Level ,[object Object],[object Object],[object Object],[object Object]
Pharmacokinetics & Pharmacodynamic   ,[object Object],[object Object]
Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object]
Pharmacodynamic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pharmacodynamic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Morphine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Analgesia ,[object Object],[object Object],[object Object],[object Object]
At the spinal cord level   ,[object Object],[object Object],[object Object],[object Object],[object Object]
At the Supraspinal level ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
At Peripheral Level   ,[object Object],[object Object],[object Object],[object Object]
Pain Relief   ,[object Object],[object Object],[object Object]
Effect on MAC of Volatile Anesthetics   ,[object Object],[object Object],[object Object]
Other Central Nervous System Effects   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hormonal Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Respiratory Depression   ,[object Object],[object Object],[object Object],[object Object]
Cautions  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cough Reflex   ,[object Object],[object Object]
Muscle Rigidity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Nausea and Vomiting   ,[object Object],[object Object],[object Object],[object Object],[object Object]
The vomiting center   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Antiemetic   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Gastrointestinal Motility and Secretion   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Biliary Tract   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Genitourinary Effects   ,[object Object],[object Object],[object Object]
Histamine Release   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cardiovascular Effects   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Disposition Kinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Active Metabolites ,[object Object],[object Object]
Dosage and Administration of Morphine   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Extra Info. ,[object Object],[object Object],[object Object],[object Object]
Meperidine   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Analgesia and Effect on MAC of Volatile Anesthetics   ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Side Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cardiovascular Effects ,[object Object],[object Object],[object Object]
Shivering   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Disposition Kinetics   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Active Metabolites   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dosage and Administration of Meperidine   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Methadone   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Analgesia and Use in Anesthesia   ,[object Object],[object Object],[object Object]
Side Effects ,[object Object],[object Object],[object Object],[object Object],[object Object]
Disposition Kinetics ,[object Object],[object Object],[object Object],[object Object],[object Object]
Dosage and Administration of Methadone   ,[object Object],[object Object],[object Object]
Fentanyl   ,[object Object],[object Object],[object Object],[object Object]
Analgesia   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Use in Anesthesia ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
stress - free anesthesia   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Other CNS Effects   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Respiratory Depression   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Airway Reflexes ,[object Object],[object Object]
Cardiovascular Effects   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Extra Info. ,[object Object],[object Object],[object Object],[object Object]
Endocrine Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Smooth Muscle and Gastrointestinal Effects   ,[object Object],[object Object],[object Object],[object Object]
Disposition Kinetics   ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dosage and Administration of Fentanyl   ,[object Object],[object Object],[object Object],[object Object]
Intubation Time ,[object Object],[object Object],[object Object],[object Object]
cardiac surgery   ,[object Object],[object Object],[object Object]
Sufentanil   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Analgesia   ,[object Object],[object Object]
Use in Anesthesia ,[object Object],[object Object],[object Object]
Other CNS Effects   ,[object Object],[object Object],[object Object],[object Object]
In patients with intracranial tumors   ,[object Object]
Respiratory Depression ,[object Object],[object Object],[object Object],[object Object]
CVS Effects ,[object Object],[object Object],[object Object],[object Object],[object Object]
Endocrine Effects ,[object Object],[object Object]
Disposition Kinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dosage and Administration   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cardiac Anesthesia   ,[object Object],[object Object]
Alfentanil   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Analgesia   ,[object Object]
Use in Anesthesia ,[object Object],[object Object],[object Object],[object Object]
Other CNS Effects   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Neurosurgical patients   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Respiratory Depression ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cardiovascular Effects ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Nausea and Vomiting ,[object Object],[object Object]
Disposition Kinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Dosage and Administration   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Intubation ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
For Long Procedures   ,[object Object],[object Object],[object Object],[object Object]
Cardiac Surgery   ,[object Object],[object Object],[object Object]
Remifentanil   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Analgesia   ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Use in Anesthesia ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
TIVA ,[object Object],[object Object],[object Object],[object Object]
Cardiac Anesthesia   ,[object Object],[object Object],[object Object],[object Object]
Monitored Anesthesia Care ,[object Object],[object Object],[object Object],[object Object],[object Object]
Other CNS Effects   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Motor - Evoked Potentials   ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Respiratory Depression ,[object Object],[object Object],[object Object],[object Object],[object Object]
Recovery from Resp. Depression ,[object Object],[object Object],[object Object],[object Object],[object Object]
Hemodynamic Effects ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Coronary Artery Disease   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cardiac Surgery   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Gastrointestinal Effects ,[object Object],[object Object],[object Object],[object Object]
Remifentanil   ,[object Object],[object Object],[object Object]
Other Side Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Disposition Kinetics ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dosage and Administration   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Induction Dosage, Intubation, LMA Placement   ,[object Object],[object Object],[object Object],[object Object]
[object Object]
[object Object]
Maintenance of General Anesthesia   ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
Cardiac Surgery ,[object Object],[object Object]
A disadvantage of remifentanil   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Monitored Anesthesia Care   ,[object Object],[object Object],[object Object]
ESWT ,[object Object]
Ophthalmologic Surgery ,[object Object],[object Object]
Regional Anesthesia ,[object Object],[object Object],[object Object]
Partial Agonists and Mixed Agonist–Antagonists   ,[object Object],[object Object],[object Object],[object Object]
[object Object]
[object Object],[object Object],[object Object]
[object Object]
Receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The major role for using them ,[object Object],[object Object],[object Object]
Nalbuphine   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Study ,[object Object],[object Object],[object Object]
Side Effects ,[object Object],[object Object],[object Object]
Comparison with fentanyl ,[object Object],[object Object],[object Object],[object Object]
Features ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Butorphanol   ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Extra Info. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Buprenorphine   ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object]
Extra Info. ,[object Object],[object Object],[object Object],[object Object]
Opioid Antagonists   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Naloxone   ,[object Object],[object Object],[object Object],[object Object]
Naltrexone   ,[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Side Effects ,[object Object],[object Object],[object Object],[object Object],[object Object]
The Mechanism Pulm. Edema ,[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Using As Infusion ,[object Object],[object Object],[object Object]
Use of Opioids in Clinical Anesthesia   ,[object Object],[object Object],[object Object],[object Object],[object Object]
For induction of anesthesia   ,[object Object],[object Object]
During maintenance of general anesthesia   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object]
 
[object Object],[object Object]
Context - Sensitive Half - Time   ,[object Object]
Explanation  ,[object Object]
[object Object]
[object Object]
Context - sensitive half - times
THANK YOU

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