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INFLAMMATI0N Dr. EJAZ WARIS , FCPS Assistant Professor Histopathology,FMHC
Introduction:  ,[object Object],[object Object],[object Object],[object Object]
Lewis Triple Response: ,[object Object],[object Object],[object Object]
Gastric Ulcer:
Laryngitis:
Acute Enteritis:
Pneumonia
Cardinal Signs of Inflammation ,[object Object],[object Object],[object Object],[object Object],[object Object]
The 5 Cardinal Signs of  Heat  Redness  Swelling  Pain  Loss Of Func.
Inflammation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cells of inflammation
Circulating cells
 
 
 
 
 
 
Connective tissue matrix ,[object Object],[object Object],[object Object],[object Object],[object Object]
Connective tissue cells
 
 
 
 
 
Acute Inflammation - Mechanism 1.Alterations in vascular calibre leading to increased blood flow 2.Microvasculature structural changes 3.Leukocyte emigration
Vascular changes ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Vascular changes continued ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
How does endothelium becomes leaky in inflammation? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Leukocyte emigration/extravasation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mechanism of Inflammation:
 
Adhesion molecules ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adhesion molecules ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Neutrophil Margination
Vascular changes
Pneumonia - Exudation
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