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Medicine 5th year, 8th lecture/part one (Dr. Sabir)
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The lecture has been given on Apr. 3rd, 2011 by Dr. Sabir.
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Medicine 5th year, 8th lecture/part one (Dr. Sabir)
1.
Hemolysis and Hemolytic
Anemias Dr. Sabir
2.
3.
4.
5.
6.
7.
8.
Polychromatophilic cell
on Wright-Giemsa staining Reticulocytes (supravital staining)
9.
10.
Frontal Bossing Results
from increased erythropoietic activity and marrow space expansion
11.
12.
13.
14.
15.
16.
17.
18.
HEREDITARY SPHEROCYTOSIS Osmotic
Fragility
19.
Osmotic Fragility Normal
Abnormal- HS cells lyse more readily at low ionic strength
20.
Congenital Hemolytic Anemias
Enzyme Defects
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
Acquired Hemolytic Anemias
Immune-Mediated Hemolysis
31.
32.
33.
34.
35.
Direct Coomb’s Test
Patient’s RBCs coated with IgG or C3 Antibodies to human IgG/C3 (Coomb’s reagent) Agglutinationin the test tube
36.
Indirect Coomb’s Test
Agglutinationin the test tube Patient serum containing anti RBC Abs Normal RBCs and Coomb’s reagent
37.
38.
Spherocyte Formation Progressive
loss of membrane, loss of surface area, more spherocytic shape
39.
40.
Warm Autoimmune Hemolytic
Anemia - spherocytes
41.
42.
43.
44.
45.
Digital ischemia from
cold-agglutinin disease
46.
47.
48.
49.
50.
51.
MAHA - Schistocytes
52.
53.
54.
55.
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