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Marek Kimmel, PhD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Marek Kimmel, PhD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Stochastic effects in cell proliferation
 
Colony of E. coli cells
Sectoring Phenotype 4 Red Sectors in Streak-out Section ,[object Object],[object Object]
Cumulative distributions of colony sizes via branching processes
Telomere shortening
Incomplete DNA replication problem (1)  ,[object Object],[object Object]
Telomere lengths in cloned sheep Shiels  et al  (1999)  Nature    Cloned      Control
Consequences of telomere shortening ,[object Object],[object Object],[object Object]
Why is  stochastic signal transduction/regulation  important? ,[object Object],[object Object],[object Object]
Intrinsic sources of stochasticity ,[object Object],[object Object]
Nuclear Receptor Regulation at the Promoter Other CoA’s RNA Polymerase General Transcription  Factors PGCs TRAP/ DRIP ASC1/2 P/CAF TRIP230 WPBs ARA70 CARM1 UbcH7 CBP Itch SSA Rb Transcription E6-AP BRG1 SRA p160’s Variable Output ER ER HRE Reporter Gene TATA
 
White et al. experiments

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04 Kimmel, Marek