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ANTIOXIDANTS ANDANTIOXIDANTS AND
VITAMINSVITAMINS
INDIAN DENTAL ACADEMY
Leader in continuing Dental Education
www.indiandentalacademy.comwww.indiandentalacademy.com
11 Antioxidants are group ofAntioxidants are group of
chemical compounds that canchemical compounds that can
deactivate the free radicalsdeactivate the free radicals
and prevent their formation.and prevent their formation.
They also stimulate theThey also stimulate the
immune system to increaseimmune system to increase
our protection against allour protection against all
diseases.diseases.
www.indiandentalacademy.comwww.indiandentalacademy.com
2 These nutrients stop fat from2 These nutrients stop fat from
undergoing auto oxidation andundergoing auto oxidation and
react with a free radical muchreact with a free radical much
more rapidly than the bodymore rapidly than the body
components do.components do.
www.indiandentalacademy.comwww.indiandentalacademy.com
www.indiandentalacademy.comwww.indiandentalacademy.com
Indian Dental academy
• www.indiandentalacademy.com
• Leader continuing dental education
• Offer both online and offline dental
courses
The major antioxidantThe major antioxidant
nutrients includenutrients include
Vitamin EVitamin E
vitamin Cvitamin C
BetacaroteneBetacarotene
BioflavonoidsBioflavonoids
Lipoic acidLipoic acid
MineralsMinerals
www.indiandentalacademy.comwww.indiandentalacademy.com
Minerals are not directMinerals are not direct
antioxidants but are needed toantioxidants but are needed to
make the antioxidant enzymesmake the antioxidant enzymes
SeleniumSelenium
Magnesium Zinc and CopperMagnesium Zinc and Copper
IronIron
ChromiumChromium
www.indiandentalacademy.comwww.indiandentalacademy.com
DEFINITIONDEFINITION
Free radicals are very active molecules orFree radicals are very active molecules or
fraction of molecules. These free radicalsfraction of molecules. These free radicals
exists independently with only one electronexists independently with only one electron
in one or more orbit. Such a lone electron isin one or more orbit. Such a lone electron is
called an unpaired electroncalled an unpaired electron
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FORMATION OF FREEFORMATION OF FREE
RADICALSRADICALS
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COMMON FREE RADICALSCOMMON FREE RADICALS
OF BIOLOGIC IMPORTANCEOF BIOLOGIC IMPORTANCE
1 HYDOGEN ATOMS1 HYDOGEN ATOMS
2 OXYGEN MOLECULES2 OXYGEN MOLECULES
3 SUPEROXIDE ANIONS3 SUPEROXIDE ANIONS
4 HYDROXYL4 HYDROXYL
5 NITRIC OXIDE5 NITRIC OXIDE
6 PEROXY NITRATE6 PEROXY NITRATE
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FREE RADICALSFREE RADICALS
PRODUCE DAMAGEPRODUCE DAMAGE
1ACTION ON D.N.A1ACTION ON D.N.A
2 OXIDATION OF FATTY COMPOUNDS2 OXIDATION OF FATTY COMPOUNDS
3FUSE PROTEINS TOGETHER3FUSE PROTEINS TOGETHER
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CLINICAL USES OFCLINICAL USES OF
ANTIOXIDANTSANTIOXIDANTS
1 ANTIOXIDANTS OF NATURAL1 ANTIOXIDANTS OF NATURAL
ORIGINORIGIN
SODSOD
ALPHA-TOCOFEROLALPHA-TOCOFEROL
ASCORBIC ACIDASCORBIC ACID
OTHER PHYSIOLOGICAL ANTIOXIDANTSOTHER PHYSIOLOGICAL ANTIOXIDANTS
AdenosineAdenosine
LactoferrinLactoferrin
NicotinamideNicotinamidewww.indiandentalacademy.comwww.indiandentalacademy.com
SYNTHETICSYNTHETIC
ANTIOXIDANTSANTIOXIDANTS
MERCAPTOPROPIONYLGLYCINEMERCAPTOPROPIONYLGLYCINE
EBSELENEBSELEN
XANTHINE OXIDASE INHIBITORSXANTHINE OXIDASE INHIBITORS
DESFERRIOXAMINEDESFERRIOXAMINE
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VITAMINSVITAMINS
Vitamin B 1Vitamin B 1
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Vitamin B 2Vitamin B 2
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Vitamin B 4Vitamin B 4
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Vitamin B6Vitamin B6
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• Vitamin B 12Vitamin B 12
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Vitamin CVitamin C
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Antioxidants and vitamins /endodontic courses

  • 1. ANTIOXIDANTS ANDANTIOXIDANTS AND VITAMINSVITAMINS INDIAN DENTAL ACADEMY Leader in continuing Dental Education www.indiandentalacademy.comwww.indiandentalacademy.com
  • 2. 11 Antioxidants are group ofAntioxidants are group of chemical compounds that canchemical compounds that can deactivate the free radicalsdeactivate the free radicals and prevent their formation.and prevent their formation. They also stimulate theThey also stimulate the immune system to increaseimmune system to increase our protection against allour protection against all diseases.diseases. www.indiandentalacademy.comwww.indiandentalacademy.com
  • 3. 2 These nutrients stop fat from2 These nutrients stop fat from undergoing auto oxidation andundergoing auto oxidation and react with a free radical muchreact with a free radical much more rapidly than the bodymore rapidly than the body components do.components do. www.indiandentalacademy.comwww.indiandentalacademy.com
  • 4. www.indiandentalacademy.comwww.indiandentalacademy.com Indian Dental academy • www.indiandentalacademy.com • Leader continuing dental education • Offer both online and offline dental courses
  • 5. The major antioxidantThe major antioxidant nutrients includenutrients include Vitamin EVitamin E vitamin Cvitamin C BetacaroteneBetacarotene BioflavonoidsBioflavonoids Lipoic acidLipoic acid MineralsMinerals www.indiandentalacademy.comwww.indiandentalacademy.com
  • 6. Minerals are not directMinerals are not direct antioxidants but are needed toantioxidants but are needed to make the antioxidant enzymesmake the antioxidant enzymes SeleniumSelenium Magnesium Zinc and CopperMagnesium Zinc and Copper IronIron ChromiumChromium www.indiandentalacademy.comwww.indiandentalacademy.com
  • 7. DEFINITIONDEFINITION Free radicals are very active molecules orFree radicals are very active molecules or fraction of molecules. These free radicalsfraction of molecules. These free radicals exists independently with only one electronexists independently with only one electron in one or more orbit. Such a lone electron isin one or more orbit. Such a lone electron is called an unpaired electroncalled an unpaired electron www.indiandentalacademy.comwww.indiandentalacademy.com
  • 8. FORMATION OF FREEFORMATION OF FREE RADICALSRADICALS www.indiandentalacademy.comwww.indiandentalacademy.com
  • 9. COMMON FREE RADICALSCOMMON FREE RADICALS OF BIOLOGIC IMPORTANCEOF BIOLOGIC IMPORTANCE 1 HYDOGEN ATOMS1 HYDOGEN ATOMS 2 OXYGEN MOLECULES2 OXYGEN MOLECULES 3 SUPEROXIDE ANIONS3 SUPEROXIDE ANIONS 4 HYDROXYL4 HYDROXYL 5 NITRIC OXIDE5 NITRIC OXIDE 6 PEROXY NITRATE6 PEROXY NITRATE www.indiandentalacademy.comwww.indiandentalacademy.com
  • 10. FREE RADICALSFREE RADICALS PRODUCE DAMAGEPRODUCE DAMAGE 1ACTION ON D.N.A1ACTION ON D.N.A 2 OXIDATION OF FATTY COMPOUNDS2 OXIDATION OF FATTY COMPOUNDS 3FUSE PROTEINS TOGETHER3FUSE PROTEINS TOGETHER www.indiandentalacademy.comwww.indiandentalacademy.com
  • 11. CLINICAL USES OFCLINICAL USES OF ANTIOXIDANTSANTIOXIDANTS 1 ANTIOXIDANTS OF NATURAL1 ANTIOXIDANTS OF NATURAL ORIGINORIGIN SODSOD ALPHA-TOCOFEROLALPHA-TOCOFEROL ASCORBIC ACIDASCORBIC ACID OTHER PHYSIOLOGICAL ANTIOXIDANTSOTHER PHYSIOLOGICAL ANTIOXIDANTS AdenosineAdenosine LactoferrinLactoferrin NicotinamideNicotinamidewww.indiandentalacademy.comwww.indiandentalacademy.com
  • 12. SYNTHETICSYNTHETIC ANTIOXIDANTSANTIOXIDANTS MERCAPTOPROPIONYLGLYCINEMERCAPTOPROPIONYLGLYCINE EBSELENEBSELEN XANTHINE OXIDASE INHIBITORSXANTHINE OXIDASE INHIBITORS DESFERRIOXAMINEDESFERRIOXAMINE www.indiandentalacademy.comwww.indiandentalacademy.com
  • 13. VITAMINSVITAMINS Vitamin B 1Vitamin B 1 www.indiandentalacademy.comwww.indiandentalacademy.com
  • 14. Vitamin B 2Vitamin B 2 www.indiandentalacademy.comwww.indiandentalacademy.com
  • 15. Vitamin B 4Vitamin B 4 www.indiandentalacademy.comwww.indiandentalacademy.com
  • 17. • Vitamin B 12Vitamin B 12 www.indiandentalacademy.comwww.indiandentalacademy.com