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Provocations Roundtable,
EHPS, Bordeaux, 2013
Most Findings in Health
Psychology
Are Not Believable
James C. Coyne
University of Groningen, University Medical Center
Groningen (UMCG), The Netherlands
@CoyneoftheRealm
Psychology and psychiatry articles
5 times more likely to report
positive findings than articles in
physics and other hard sciences.
Can we trust what we read in
journals?
Ioannidis, J. P. (2005). Why most published
research findings are false. PLoS medicine,
2(8), e124.
Shun-Shin, M. J., & Francis, D. P. (2013). Why
Even More Clinical Research Studies May Be
False: Effect of Asymmetrical Handling of
Clinically Unexpected Values. PLOS ONE,
8(6), e65323.
Copyright ©2005 American Heart Association
Modified from Loscalzo, J. Circulation 2005;112:3026-3029
Incentives and Pressures ForIncentives and Pressures For
Confirmatory BiasConfirmatory Bias
Ioannidis, J. (2012). Scientific inbreeding
and same-team replication: Type D
personality as an example. Journal of
Psychosomatic Research.
 Obedient replication: Investigators feel that
the prevailing views are so dominant that
finding consistent results is a sign of being a
good scientist and there is no room for
dissenting results and objections.
Ioannidis, J. (2012). Scientific inbreeding
and same-team replication: Type D
personality as an example. Journal of
Psychosomatic Research.
 Obliged replication: Proponents of dominant
view are so strong in controlling the
publication venues that they can largely
select and mold the results, wording, and
interpretation of studies eventually published.
Telling It Like It Ain’t: How toTelling It Like It Ain’t: How to
Succeed in Health PsychologySucceed in Health Psychology

Have Lots of Endpoints and Ignore
Negative Results in Main Analyses of
Primary Endpoints.

Favor Secondary Analyses, Subgroup
Analyses, and Endpoints Developed Post
Hoc over Negative Findings for Primary
Analyses.

Ignore Methodological Shortcomings that
Would Make Trial or Meta Analyses
Invalid.
Telling It Like It Ain’t: How toTelling It Like It Ain’t: How to
Succeed in Health PsychologySucceed in Health Psychology
• Present Negative Findings as if Positive in
Subsequent Publications, Exaggerate
Positive Findings.

Assess Multiple Endpoints, Treat any
Significant Finding as a Replication of Past
Findings.

Create a False Consensus and Seeming
Unanimity in the Literature by
Cherrypicking Findings that can be
Construed as Positive, Ignoring the Rest.
Do we modify Sackett’s definition of evidence-
based medicine as "the conscientious, explicit
and judicious use of current best evidence in
making decisions about the care of individual
patients”
To
Evidence-based health psychology is ‘the careful
selection, analysis, and interpretation of results to
put theories and interventions in the best
possible light, upholding the credibility of the
field.’
Change what is viewed as “for
the good of the field”
 Need to stop viewing producing evidence
upholding dominant theories and efficacy of
interventions as overarching goal of
publication.
 Need to recognize null findings,
nonreplication, and criticism of dominant
views as accomplishments in need of
protecting and publishing.

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Most Health Psych Findings Not Believable

  • 1. Provocations Roundtable, EHPS, Bordeaux, 2013 Most Findings in Health Psychology Are Not Believable James C. Coyne University of Groningen, University Medical Center Groningen (UMCG), The Netherlands @CoyneoftheRealm
  • 2. Psychology and psychiatry articles 5 times more likely to report positive findings than articles in physics and other hard sciences.
  • 3. Can we trust what we read in journals? Ioannidis, J. P. (2005). Why most published research findings are false. PLoS medicine, 2(8), e124. Shun-Shin, M. J., & Francis, D. P. (2013). Why Even More Clinical Research Studies May Be False: Effect of Asymmetrical Handling of Clinically Unexpected Values. PLOS ONE, 8(6), e65323.
  • 4. Copyright ©2005 American Heart Association Modified from Loscalzo, J. Circulation 2005;112:3026-3029 Incentives and Pressures ForIncentives and Pressures For Confirmatory BiasConfirmatory Bias
  • 5. Ioannidis, J. (2012). Scientific inbreeding and same-team replication: Type D personality as an example. Journal of Psychosomatic Research.  Obedient replication: Investigators feel that the prevailing views are so dominant that finding consistent results is a sign of being a good scientist and there is no room for dissenting results and objections.
  • 6. Ioannidis, J. (2012). Scientific inbreeding and same-team replication: Type D personality as an example. Journal of Psychosomatic Research.  Obliged replication: Proponents of dominant view are so strong in controlling the publication venues that they can largely select and mold the results, wording, and interpretation of studies eventually published.
  • 7. Telling It Like It Ain’t: How toTelling It Like It Ain’t: How to Succeed in Health PsychologySucceed in Health Psychology  Have Lots of Endpoints and Ignore Negative Results in Main Analyses of Primary Endpoints.  Favor Secondary Analyses, Subgroup Analyses, and Endpoints Developed Post Hoc over Negative Findings for Primary Analyses.  Ignore Methodological Shortcomings that Would Make Trial or Meta Analyses Invalid.
  • 8. Telling It Like It Ain’t: How toTelling It Like It Ain’t: How to Succeed in Health PsychologySucceed in Health Psychology • Present Negative Findings as if Positive in Subsequent Publications, Exaggerate Positive Findings.  Assess Multiple Endpoints, Treat any Significant Finding as a Replication of Past Findings.  Create a False Consensus and Seeming Unanimity in the Literature by Cherrypicking Findings that can be Construed as Positive, Ignoring the Rest.
  • 9. Do we modify Sackett’s definition of evidence- based medicine as "the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients” To Evidence-based health psychology is ‘the careful selection, analysis, and interpretation of results to put theories and interventions in the best possible light, upholding the credibility of the field.’
  • 10. Change what is viewed as “for the good of the field”  Need to stop viewing producing evidence upholding dominant theories and efficacy of interventions as overarching goal of publication.  Need to recognize null findings, nonreplication, and criticism of dominant views as accomplishments in need of protecting and publishing.