hematologi 1

1. 23 MEI 2011
Leukopoiesis

2. Blood Cytology
 That fact that we as humans are made up of
millions of tiny cells.
 Cytology, more commonly known as cell
biology, studies cell structure, cell
composition, and the interaction of cells with
other cells and the larger environment in which
they exist.
 Cytology can also refer to cytopathology, which
analyzes cell structure to diagnose disease.

3. KOMPOSISI DARAH
PADAT (45%)
 ERITROSIT
Fungsi : Alat Transportasi
 LEKOSIT
Fungsi: Pertahanan tubuh
 TROMBOSIT
Fungsi : Membantu proses
pembekuan darah
CAIR (55%)
 Air (90-92%)
 Protein (Alb,Glo, Fibr)
 Karbohidrat
 Vitamin
 Hormon
 Enzym
 Lemak
 Garam/mineral
Rata-rata jumlah darah orang dewasa
sekitar 5 liter atau 7% - 8% dari berat badan
Darah terdiri dari dua bagian:

4. HAEMATOPOIESIS:
berarti proses pembentukan darah.
Pada manusia hematopoiesis dimulai di yolk sac. pada
bulan ke 3 gestasi, stem cell berpindah ke liver dan
spleen sampai bulan ke 7, yang pada akhirnya digantikan
oleh BM. Setiap sel darah berasal dari stem cell
(pluripotent). Diperkirakan terdapat 1 stem cell dalam
10.000 cell dalam BM. Jika pembentukan darah di BM
terganggu, sel yang pertama turun adalah netrophil (yang
mempunyai masa hidup 6-8 jam), diikuti oleh trombosit
(masa hidup 10 hari). Anemia berkembang secara
lambat. (masa hidup 120 hari)

5. Leukopoiesis
 Leukopoiesis is a form of hematopoiesis in
which white blood cells (WBC, or leukocytes)
are formed in bone marrow located in bones
in adults and hematopoietic organs in the
fetus.White blood cells, indeed all blood
cells, are formed from the differentiation of
pluripotent hematopoietic stem cells which
give rise to several cell lines with more limited
differentiation potential.

6. Leukopoiesis
Myeloid Stem Cell
Productions
 This stem cell will
differentiate into either a
proerythroblast (and
eventually a red blood
cell) or a progenitor cell.
The progenitor cell will
differentiate into a
megakaryocyte (and
then a platelet), or a
myeloblast or
monoblast.
Lymphoid Stem Cell
Productions
 Lymphoid stem cells
mature into
lymphoblasts, and then
prolymphocytes, and
finally mature
lymphocytes, either a B
orT cell.
Leukopoiesis is a form of haematopoiesis in which white blood cells (WBC) are formed
in the bone marrow. WBCs arise from the maturation of hemocytoblasts, which are the
general stem cell for all blood cells and platelets, into various pluripotential stem cells
which can then further differentiate into the different classes of WBCs.

8. Masa Pembentukan Sel-sel Darah
(erytrocyte,Megakaryocyte,Granulocyte,Lympocyte,Monocyte)

9. Masa Pembentukan Lekosit

10. Granulopo
iesis