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Disease systems biology

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Lars Juhl Jensen
Lars Juhl Jensen
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Disease Systems Biology Lars Juhl Jensen
protein networks
cellular signaling
Horn, Schoof et al., in preparation, 2012
sequence motif atlas
functional associations
Szklarczyk, Franceschini et al., Nucleic Acids Research, 2011
computational predictions
experimental data
curated knowledge
confidence scores
orthology-based transfer
Franceschini, Szklarczyk, Frankild et al., Nucleic Acids Research, 2013
functional modules
Palleja et al., in preparation, 2012
literature mining
~22 million abstracts
~4 million full-text articles
comprehensive lexicon
co-mentioning
proteins
compartments
compartments.jensenlab.org
tissues
tissues.jensenlab.org
diseases
diseases.jensenlab.org
diseases.jensenlab.org
behavioral phenotypes
diseases.jensenlab.org
medical data mining
electronic health records
Jensen et al., Nature Reviews Genetics, 2012
structured data
Jensen et al., Nature Reviews Genetics, 2012
unstructured data
patient stratification
Roque et al., PLoS Computational Biology, 2011
comorbidity
Roque et al., PLoS Computational Biology, 2011
disease trajectories
Jensen et al., in preparation, 2012
pharmacovigilance
Eriksson et al., in preparation, 2012
conferences
questions?

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Disease systems biology