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Disease systems biology
1.
Disease Systems Biology
Lars Juhl Jensen
2.
protein networks
3.
cellular signaling
4.
Horn, Schoof et
al., in preparation, 2012
5.
sequence motif atlas
6.
functional associations
7.
Szklarczyk, Franceschini et
al., Nucleic Acids Research, 2011
8.
computational predictions
9.
experimental data
10.
curated knowledge
11.
confidence scores
12.
orthology-based transfer
13.
Franceschini, Szklarczyk, Frankild
et al., Nucleic Acids Research, 2013
14.
functional modules
15.
Palleja et al.,
in preparation, 2012
16.
literature mining
17.
~22 million abstracts
18.
~4 million full-text
articles
19.
comprehensive lexicon
20.
co-mentioning
21.
proteins
22.
compartments
23.
compartments.jensenlab.org
24.
tissues
25.
tissues.jensenlab.org
26.
diseases
27.
diseases.jensenlab.org
28.
diseases.jensenlab.org
29.
behavioral phenotypes
30.
diseases.jensenlab.org
31.
medical data mining
32.
electronic health records
33.
Jensen et al.,
Nature Reviews Genetics, 2012
34.
structured data
35.
Jensen et al.,
Nature Reviews Genetics, 2012
36.
unstructured data
37.
38.
patient stratification
39.
Roque et al.,
PLoS Computational Biology, 2011
40.
comorbidity
41.
Roque et al.,
PLoS Computational Biology, 2011
42.
disease trajectories
43.
Jensen et al.,
in preparation, 2012
44.
pharmacovigilance
45.
Eriksson et al.,
in preparation, 2012
46.
conferences
47.
48.
49.
questions?
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