1. WELCOME

2. BRAIN TONICS Under the guidance of Dr. T.Vedavathi M.Pharm,Phd Professor CMR College Of Pharmacy By K.Sujana Regd.No.10T22S0116 M.Pharm 1st Year (P’cology) CMR College of Pharmacy

3. BRAIN TONICS BRAIN TONICS

4. CONTENTS INTRODUCTION BRAIN TONICS BRAIN TONIC & MEMORY BOOSTER HERBS FORMULATION OF BRAIN TONIC CONCLUSION BIBILIOGRAPHY

5. INTRODUCTION The human brain is one of the most sophisticated organs nature has ever made. One of the most interesting aspects of the brain is its power to retain information, which we call as memory. Memory is perhaps the most vital of the aspects that differentiates human beings from other animals.

7. Two abnormal structures called plaques and tangles are prime suspects in damaging and killing nerve cells.

8. There are two types of AD -- early onset and late onset In early onset AD, symptoms first appear before age 60. Early onset AD is much less common than late onset. However, it tends to progress rapidly. Early onset disease can run in families. Several genes have been identified. Late onset AD, the most common form of the disease, develops in people age 60 and older. Late onset AD may run in some families, but the role of genes is less clear.

9. The early symptoms of AD can include Language problems, such as trouble finding the name of familiar objects Misplacing items Getting lost on familiar routes Personality changes and loss of social skills Losing interest in things previously enjoyed, flat mood As the AD becomes worse, symptoms are more obvious and interfere with your ability to take care of yourself. Symptoms can include Forgetting details about current events Change in sleep patterns, often waking up at night

10. People with severe AD can no longer: Understand language Recognize family members Perform basic activities of daily living, such as eating, dressing, and bathing

12. Ideal for students and elderly people.

13. Prevents early ageing of brain cellsImproves functioning of other organs by stimulating central nervous system. Improves concentration and memory Increases blood flow to the brain Reduces the frequency of headaches Supports systemic balance on a cellular level

15. FAMILY:Gingkoaceae

16. BIOLOGICAL SOURCE: Dried leaves of Gingkobiloba

18. Ginkgo biloba DOSAGE : gingko supplements are usually taken in the range of 40-200mg per day.

19. LIQUORICE Also known as yastimadhu, Mulethi. FAMILY: Leguminosae BIOLOGICAL SOURCE: dried unpeeled roots and stolons of glycyrrhizaglabra.

20. CHEMICAL CONSTITUENTS: triterpinoidsaponin glycyrrhizin, potassium and calcium salts of glycyrrhizinic acids Another important chemical aspect of liquorice is the presence of flavonoids. A compound carbenoxolone is derived from liquorice. Uses: Mulethi is an efficient brain tonic and a re-vitalizer for the brain. mulethi also rejuvenates the brain.

22. Also contains monohydric Alcohols and fatty acids. USES: Ashwagandha is one of the most essential components used in enhancing memory and overall brain functioning. Ashwagandha is an adaptogen,stress-buster and a re-vitalizer. Ayurveda regards ashwagandha as a medharasayana,i.e. a brain tonic.

23. It is a vital component of almost all herbal brain tonics available in the market. DOSAGE:1 or 2 capsules twice everyday with meals.- oral administration of ashwagandha for five days suggested that anxiety-relieving effects similar to those achieved by the anti-anxiety drug lorazepam.

24. CENTELLA ASIATICA Also known as Gotukola,mandukparni, SaraswathiPlant BIOLOGICAL SOURCE: It has long-stalked, green reniformleaves of centellaasiatica. FAMILY:mackinlayaceae

25. CHEMICAL CONSTITUENTS: The primary constituents of gotu kola are triterpenoid compounds. The major triterpenoid components are: asiatic acid, madecassic acid, asiaticoside and madecassoside. The plant is also a source of calcium and sodium.

26. USES The gotu kola is very effective in increasing the circulation of blood to brain. It protects the brain from damage due to the wear and tear of its cells. Gotu kola is generally used in tonics intended to re-vitalize the brain. It improves concentration. Centellaasiatica may be useful in the treatment of Anxiety and may be used as a promising anxiolytic agent in the future. DOSAGE:1 or 2 capsules twice daily with meals.

27. ACORUS CALAMUS Also known as calamus root or sweet flag BIOLOGICAL SOURCE: Dried rhizomes of the plant known as Acoruscalamus. Family:Araceae CHEMICAL CONSTITUENTS :The drug contains 1.5 to 3.5% of volatile oil contains asaraldehyde.The other contents of the oil are asarone and eugenol.Calamus also contains a bitter amorphous principle known as acorine.The other constituents are Hydrocarbons ,trimethylamine,beta-asarone,camphone.

28. Uses: Vacha is a very vigorous brain tonic, because it shows results in a very short time. It increases the overall memory of the person and strengthens the nervous system.Vacha is prescribed to people who have amnesia. It also increases blood supply to brain and oxygenates it.

29. DOSAGE: The root or rhizome can be chewed or to be taken a pinch of powder in teaspoonful of honey.

30. BACOPA MONNIERI Known as BRAHMI BIOLOGICAL SOURCE: Contains of fresh and dried leaves and stems of the plant bacopamonnieri. Family:Scrophulariaceae CHEMICALCONSTITUENTS : contains alkaloids bramine and saponins namely bacosides A & B it also contains betulic acid, stigmasterol, monnierin and hersaponin .

31. USES: Brahmi is used as nerve tonic and treatment of epilepsy. Improves memory and enhances recall. Increases concentration and intellect. Increases brain capacity to take additional load. Relives mental stress and strain. DOSAGE : suggested dose: Adults powder: 2 teaspoonsful twice a day in milk. capsule-:1 capsule twice a day preferably with milk. Children : 1-2 teaspoonsful twice a day in milk.

32. CONVOLVULUS PLURICAULIS Also known as shankhapushpi, bindweed. Family: Convolvulaceae BIOLOGICAL SOURCE :areial parts of plant convolvulus pluricaulis. CHEMICAL CONSTITUENTS; contains many phytonutrients like convolidine,convolvine convoline,confoline, phyllabine,subhirsine, sitosterol and scopoline

33. These compounds help brain stimulation and increase the ability to concentrate USES: Shankhapushpi has been regarded as powerful brain tonic,a natural memory stimulant, and a good tranquilizer. It is also used as a rasayana and rejuvenator. Shankhapushpi reduces anxiety and stress by controlling the production of body's stress harmones,adrenaline and cortisol. This plant also significantly enhances memory power and intelligence. Its powder,mixed with cumin and milk can be taken for insomnia. DOSAGE: powder- 2-4gm;paste- 10-20gm per day.

34. ARTEMISIA VULGARIS Also known as Mugwort, Common Wormwood. BIOLOGICAL SOURCE:leaves and flowering tops of the plant Artemisia vulgaris. FAMILY:Asteraceae CHEMICAL CONSTITUENTS: The important chemical constituents of mug wort are thujone,cineole,a volatile oil, acrid resin and tannin. It also cantainsflavonoids,triterpenes and coumarin derivatives

35. USES: It is recommended for people with memory deficiency due to cerebral circulation problems. This is an excellent brain tonic,useful in cerebral congestion and spinal cord stimulation because that the connection between brain and the spinal cord is so tight, that herbs which have effect on the spinal cord have great chances to influence a region of the brain. It is also prescribed for nervous and spasmodic diseases connected with debility and epilepsy.Also used for insomnia and nervousness.

36. Dosage: Tea or tincture twice daily to enhance your psychic abilities. One teaspoon per cup for infusion;5 – 20 drops tincture.

37. FORMULATION OF BRAIN TONIC: DRUG PREPARATION: Centellaasiatica leaves (2 1/2 tbsp),Piper longum fruits (1 tbsp),Zingiberofficinale rhizome (1 tbsp),Withaniasomnifera root (1tbsp), Achyranthesaspera whole plant (2 1/2 tbsp),Glycyrrhizaglabra root (1 tbsp) and Terminaliachebula fruit (2 1/2 tbsp). DOSAGE: One teaspoonful powder is given to the patient,twice daily with milk or water

38. CONCLUSION Ayurveda claims at not only increasing the powers of the brain but also at keeping the mental diseases away, along with helping to cure them desirably. These ayurvedic herbs have an Antioxidant activity and thus improve the function of the brain cells and capacity to recall. Hence these braintonics are very low in cost and are quite safe for all ages, also during pregnancy and nursing. And all the herbs ayurveda uses for its brain tonics have minimum side-effects compared to synthetic medicines.

39. THANK YOU

40. ANY QUERIES ?