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Synthesis of  (±) - Linezolid Abhijeet Patil. M.Sc. Chemistry. Fergusson College, Pune.
INTRODUCTION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Applications of Linezolid ,[object Object],[object Object],[object Object],[object Object]
Synthesis of (±) – Linezolid: Scheme
Synthesis:  3-Fluoro-4-morpholinylnitrobenzene
Synthesis:   3-Fluoro-4-morpholinylaniline
Synthesis:   N-Carboethoxy-3-fluoro-4-morpholinylaniline
Synthesis: Ethyl N-allyl N-(3-fluoro-4-morpholinophenyl) carbamate
Synthesis:   5-(Iodomethyl)-3-(4-morpholinophenyl) oxazolidin-2-one The obtained iodolactone was unstable.
Synthesis:  [N-3-(3-Fluoro-4-morphylinyl phenyl)-2-oxo-5-oxazolidinyl] methyl azide
Synthesis:  (±) - LINEZOLID
CONCLUSION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
REFERENCES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
THANK YOU ,[object Object],[object Object],[object Object],[object Object]

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Introduction new ppt!

Notes de l'éditeur

  1. Synthesis: Ethyl N-allyl N-(3-fluoro-4-morpholinophenyl) carbamate