This document compares and contrasts prokaryotic and eukaryotic cells. It notes that prokaryotes like bacteria and archaea lack complex internal structures like membrane-bound organelles, while eukaryotic cells have structures like the nucleus enclosed in membranes. A key difference is that prokaryotes have 70S ribosomes while eukaryotes have 80S ribosomes in the cytoplasm and 70S in organelles. The endosymbiotic theory proposes that mitochondria and chloroplasts were originally prokaryotic cells that lived symbiotically inside eukaryotic cells and became permanent organelles.