Stroke is a leading cause of death and disability, with 50,000 strokes occurring each year in people under 55, 10,000 deaths making it the third leading cause of death, and 20,000 people left disabled, making it the number one cause of disability. Imaging techniques can help identify the penumbra, or potentially salvageable brain tissue, to determine if clot-busting drugs may provide benefit. Improved drugs and access to proven therapies like clot removal can help reduce the impact of stroke.

2. • 50,000 strokes – ¼ under age 55
• 10,000 dead – No. 3
• 20,000 disabled – No. 1

6. Imaging the Penumbra

7. No penumbra = no benefit
likely

9. Translation – animal to human

10. Imaging the vessels

12. Better clot busting drugs
• TNK
• DSP

14. Better access to proven
therapies

17. Number needed to transport = 2.5