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Analysis and interpretation of
       surveillance data

Integrated Disease Surveillance Programme (IDSP)
Preliminary questions to the group

• Have you been involved in surveillance data
  analysis?
• What difficulties have you encountered in
  analyzing surveillance data?
• What would you like to learn about
  surveillance data analysis?




              2
Outline of this session

1.   The concept of data analysis
2.   CDC for TPP
3.   Reports
4.   Interpretation of the information




                3
What is data analysis?

• Data reduction
   Reduces the quantity of numbers to examine
   Because the human mind cannot handle too many
    bits of information at the same time
• Transforms raw data into information
   A list of cases becomes a monthly rate

  Data               Information                     Action

          Analysis                  Interpretation
                4
              Today we will focus on analysis
                                                         Why analyze?
REC SEX                     Distribution of cases by sex
--- ----
  1 M
  2 M                                  Table
  3 M
  4 F
  5 M
            Data
  6 F                    Sex         Frequency      Proportion
  7 F
  8 M                    Female                10        33.3%
  9 M
 10 M       Analysis     Male                  20        66.7%
 11 F
 12 M
 13 M                    Total                 30       100.0%
 14 M
 15 F      Information                 Graph
 16 F
 17 F
 18 M
 19 M                                                  Female
 20 M                                                  Male
 21 F
 22 M
 23 M
 24 F
 25 M
 26 M
 27 M
 28 F
 29 M
 30 M              5                                  Why analyze?
1. Count, Divide and Compare (CDC): An
   epidemiologist calculates rates and
             compare them
• Direct comparisons of absolute numbers of
  cases are not possible in the absence of rates
• CDC
   Count
     • Count (compile) cases that meet the case definition
   Divide
     • Divide cases by the corresponding population
       denominator
   Compare
     • Compare rates across age groups, districts etc.


                  6                                      CDC for TPP
Exercise

• How would you find out if diphtheria is more
  common among people who are below the poverty
  line?




               7                             CDC for TPP
Is diphtheria more common among
              poorer people?
• Count
    Count cases of diphtheria among families with and without
     a Below Poverty Line (BPL) card
• Divide
    Divide the cases of diphtheria among BPL people by the
     estimated BPL population size (e.g., census) to get the rate
    Divide the cases of diphtheria among non BPL people by
     the estimated non BPL population size (e.g., census) to get
     the rate
• Compare
    Compare the rates of diphtheria among BPL and non BPL
     people


                    8                                       CDC for TPP
2. Time, place and person
              descriptive analysis
A. Time
     Incidence over time (Graph)
A. Place
     Map of incidence by area
A. Person
     Breakdown by age, sex or personal
      characteristics
     Table of incidence by age and sex


                9                         CDC for TPP
A. Present the results of the analysis
        over time using a GRAPH
• Absolute number of cases
   Avoid analysis over longer time period as the
    population size increases
• Incidence rates
   Allows analysis over longer time period
   Analysis by week, month or year




                10                                  CDC for TPP
Absolute number of cases for analysis over a short time period

                      Acute hepatitis (E) by week, Hyderabad,
                    120
                            AP, India, March-June 2005
                    100
  Number of cases




                     80


                     60


                     40


                     20


                     0
                          1   8   15   22   29    4      12   19   26   3    10   17    24   31    7     14     21   28
                          March                  April                   May                      June
                                                               First day of week of onset

          Interpretation: The source of infection is persisting and continues to cause cases
                                                 11                                                           CDC for TPP
December
                                                                                                                                                                November
                                                                                                                                                                                                                                                                                   Reports




                                                                                                                                                                October
                                                                                                                                                                                               Interpretation: There is a seasonality in the end of the year and a trend towards




                                                                                                                                                                September
                                                                                                                                                                August
                                                                                                                                                                July
                                                                                                                                                                               2004
                                                         District, West Bengal, India, 2000-2004




                                                                                                                                                                June
                                                                                                                                                               May
                                                          Malaria in Kurseong block, Darjeeling




                                                                                                                                                                April
                                                                                                                                                                March
                                                                                                                                                                February
                                                                                                                                                                January
                                                                                                                                                                December
                                                                                                                                                                November
                                                                                                                                                                October
                                                                                                                                                                September
                                                                                                                                                                August
                                                                                                                                                                July
                                                                                                                                                                               2003




                                                                                                                                                                June
                                                                                                                                                                May
                                                                                                                                                                                                                      increasing incidence year after year
Incidence rates for analysis over a longer time period




                                                                                                                                                                April
                                                                                                                                                                March
                                                                                                                                                                February
                                                                                                                                                                January
                                                                                                                                                                December
                                                                                                                                                                November
                                                                                                                                                                October
                                                                                                                                                                September
                                                                                                                                                                August
                                                                                                                                                                July



                                                                                                                                                                               2002
                                                                                                                                                                June




                                                                                                                                                                                      Months
                                                                                                                                                                May
                                                                                                                                                                April
                                                                                                                                                                March
                                                                                                                                                               February
                                                                                                                                                                   January
                                                                                                                                                                   December
                                                                                                                                                                   November




                                                                                                                                                                                                                                                                                   12
                                                                                                                                                                   October
                                                                                                                                                                   September
                                                                                                                                                                   August
                                                                                                             Incidence of Pf malaria
                                                                                                                                                                   July




                                                                                                                                                                               2001
                                                                                                             Incidence of malaria
                                                                                                                                                                   June
                                                                                                                                                                   May
                                                                                                                                                                   April
                                                                                                                                                                   March
                                                                                                                                                                   February
                                                                                                                                                                   January
                                                                                                                                                                   December
                                                                                                                                                                   November
                                                                                                                                                                   October
                                                                                                                                                                   September
                                                                                                                                                                   August
                                                                                                                                                                   July




                                                                                                                                                                               2000
                                                                                                                                                                   June
                                                                                                                                                                   May
                                                                                                                                                                   April
                                                                                                                                                                   March
                                                                                                                                                                   February
                                                                                                                                                                   January




                                                                                                                                                           5

                                                                                                                                                               0
                                                                                                   45

                                                                                                        40

                                                                                                                   35

                                                                                                                                 30

                                                                                                                                       25

                                                                                                                                            20

                                                                                                                                                 15

                                                                                                                                                      10
                                                                                                         Incidence of malaria per 10,000
2. Present the results of the analysis by
            place using a MAP
• Number of cases
   Spot map
   Does not control for population size
   Concentration of dots may represent high
    population density only
   May be misleading in areas with heterogeneous
    population density (e.g., urban areas)
• Incidence rates
   Incidence rate map
   Controls for population size

                13                             CDC for TPP
Incidence by area
      Incidence of acute hepatitis (E) by block,
       Hyderabad, AP, India, March-June 2005
                                                 Attack rate per
                                                 100,000
                                                 population

                                                       0
                                                       1-19
                                                       20-49
                                                       50-99

                                                       100+
Open drain
                            Interpretation: Blocks with hepatitis
                              are those supplied by pipelines
Pipeline crossing
open sewage drain   14         crossing open sewage drains
3. Present the results of the analysis per
    person using an incidence TABLE
• Distribution of cases by:
   Age
   Sex
   Other characteristics
    (e.g., ethnic group, vaccination status)
• Incidence rate by:
   Age
   Sex
   Other characteristics

                15                             CDC for TPP
Incidence according to a characteristic

         Probable cases of cholera by age and
           sex, Parbatia, Orissa, India, 2003
                             Number of cases Population Incidence
      Age group    0 to4                   6         113       5.3%
      (In years)   5 to14                  4         190       2.1%
                   15 to24                 5         128       3.9%
                   25 to34                 5         144       3.5%
                   35 to44                 6         129       4.7%
                   45 to54                 4          88       4.5%
                   55 to64                 8          67      11.9%
                   > 65                    3          87       3.4%
      Sex          Male                   17         481       3.5%
                   Female                 24         465       5.2%
      Total        Total                  41         946       4.3%

                    Interpretation: Older adults and women are
                             at increased risk of cholera
                             16                                  CDC for TPP
Distribution of cases according to a characteristic

         Immunization status of measles cases,
            Nai, Uttaranchal, India, 2004
                                                 19%




                            81%

                         Immunized          Unimmunized
                  Interpretation: The outbreak is probably caused
                               by a failure to vaccinate
                                                                    CDC for TPP
Seven reports to be generated

1.   Timeliness/completeness
2.   Description by time, place and person
3.   Trends over time
4.   Threshold levels
5.   Compare reporting units
6.   Compare private / public
7.   Compare providers with laboratory


                 18                          Reports
Report 1: Completeness and timeliness

• A report is considered on time if it reaches
  the designated level within the prescribed
  time period
   Reflects alertness
• A report is said to be complete if all the
  reporting units within its catchment area
  submitted the reports on time
   Reflects reliability


                 19                              Reports
Report 2: Weekly/ monthly
             summary report
• Based upon compiled data of all the
  reporting units
• Presented as tables, graphs and maps
• Takes into account the count, divide and
  compare principle:
   Absolute numbers of cases, deaths and case
    fatality ratio are sufficient for a single reporting
    unit level
   Incidence rates are required to compare
    reporting units

                 20                                   Reports
Report 3: Comparison with previous
         weeks/ months/ years
• Help examine trend of diseases over time
• Weekly analysis compare the current week
  with data from the last three weeks
   Alerts authorities for immediate action
• Monthly and yearly analysis examine:
   Long term trends
   Cyclic pattern
   Seasonal patterns


                21                            Reports
Report 4: Crossing threshold values

• Comparison of rates with thresholds
• Thresholds that may be used:
   Pre-existing national/international thresholds
   Thresholds based on local historic data
     • Monthly average in the last three years
       (excluding epidemic periods)
   Increasing trends over a short duration of time
    (e.g., Weeks)



                  22                                  Reports
Report 5: Comparison between
             reporting units
• Compares
   Incidence rates
   Case fatality ratios
• Reference period
   Current month
• Sites concerned
   Block level and above



                 23                 Reports
Report 6: Comparison between public
           and private sectors
• Compare trends in number of new
  cases/deaths
   Incidences are not available for private provider
    since no population denominators are available
• Good correlation may imply:
   The quality of information is good
   Events in the community are well represented
• Poor correlation may suggest:
   One of the data source is less reliable

                24                                 Reports
Report 7: Comparison of reports between
   the public health system and the
              laboratory
                            Elements to compare


                Public health system       Laboratories


Validation of   •Number of cases       •Number of laboratory
reporting       seen by providers      diagnoses

Water borne     •Cases of diarrheal    •Water quality
disease         diseases

Vector borne    •Cases of vector       •Entomological data
disease         borne diseases

                 25                                          Reports
Making sense of different sources of
    information (“S” and “P” forms)
 It is not possible to mix data from different
  case definitions
   One cannot add cases coming from “S” and “P”
    forms (syndromic and presumptive diagnoses)
   It is not possible to add apples and oranges
 Use the different sources of information to
  cross validate (or “triangulate”)
   If there is an increase in the cases of dengue in
    the “P” forms, check if there is a surge in the
    number of fever cases in the “S” forms

                26                                Interpretation
What computers cannot do

           Skills                      Attitudes
• Contact reporting units    •   Looking
  for missing information
                             •   Thinking
• Interpret laboratory
  tests                      •   Discussing
• Make judgment about:       •   Taking action
    Epidemiologic linkage
    Duplicate records
    Data entry errors
• Declare a state of
  outbreak

                   27                              Interpretation
Expressed concerns versus reality

          Concerns               Mistake commonly
    commonly expressed                observed
• Statistics are difficult   • Data are not looked at
• Multivariate analysis is
  complex
• Presentation of data is
  challenging




                  28                            Interpretation
Review of analysis results by the
            technical committee
•   Meeting on a fixed day of the week
•   Search for missing values
•   Validity check
•   Interpretation of the analysis bearing in mind
     The strength and weakness of data
     The disease profiles
     The need to calculate rates before comparisons Meeting on
      a fixed day of every week
• Summary reports for dissemination
• Action

                    29                                   Interpretation
Take home messages

1. Link data collection and program
   implementation
  •   Data > Information > Action
1. Count, divide and compare for time, place
   and person description
2. Share information through reports
3. Interpret with the technical committee to
   decide action on the basis of the
   information

                30
Thank you.




31

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Analysis and interpretation of surveillance data

  • 1. Analysis and interpretation of surveillance data Integrated Disease Surveillance Programme (IDSP)
  • 2. Preliminary questions to the group • Have you been involved in surveillance data analysis? • What difficulties have you encountered in analyzing surveillance data? • What would you like to learn about surveillance data analysis? 2
  • 3. Outline of this session 1. The concept of data analysis 2. CDC for TPP 3. Reports 4. Interpretation of the information 3
  • 4. What is data analysis? • Data reduction  Reduces the quantity of numbers to examine  Because the human mind cannot handle too many bits of information at the same time • Transforms raw data into information  A list of cases becomes a monthly rate Data Information Action Analysis Interpretation 4 Today we will focus on analysis Why analyze?
  • 5. REC SEX Distribution of cases by sex --- ---- 1 M 2 M Table 3 M 4 F 5 M Data 6 F Sex Frequency Proportion 7 F 8 M Female 10 33.3% 9 M 10 M Analysis Male 20 66.7% 11 F 12 M 13 M Total 30 100.0% 14 M 15 F Information Graph 16 F 17 F 18 M 19 M Female 20 M Male 21 F 22 M 23 M 24 F 25 M 26 M 27 M 28 F 29 M 30 M 5 Why analyze?
  • 6. 1. Count, Divide and Compare (CDC): An epidemiologist calculates rates and compare them • Direct comparisons of absolute numbers of cases are not possible in the absence of rates • CDC  Count • Count (compile) cases that meet the case definition  Divide • Divide cases by the corresponding population denominator  Compare • Compare rates across age groups, districts etc. 6 CDC for TPP
  • 7. Exercise • How would you find out if diphtheria is more common among people who are below the poverty line? 7 CDC for TPP
  • 8. Is diphtheria more common among poorer people? • Count  Count cases of diphtheria among families with and without a Below Poverty Line (BPL) card • Divide  Divide the cases of diphtheria among BPL people by the estimated BPL population size (e.g., census) to get the rate  Divide the cases of diphtheria among non BPL people by the estimated non BPL population size (e.g., census) to get the rate • Compare  Compare the rates of diphtheria among BPL and non BPL people 8 CDC for TPP
  • 9. 2. Time, place and person descriptive analysis A. Time  Incidence over time (Graph) A. Place  Map of incidence by area A. Person  Breakdown by age, sex or personal characteristics  Table of incidence by age and sex 9 CDC for TPP
  • 10. A. Present the results of the analysis over time using a GRAPH • Absolute number of cases  Avoid analysis over longer time period as the population size increases • Incidence rates  Allows analysis over longer time period  Analysis by week, month or year 10 CDC for TPP
  • 11. Absolute number of cases for analysis over a short time period Acute hepatitis (E) by week, Hyderabad, 120 AP, India, March-June 2005 100 Number of cases 80 60 40 20 0 1 8 15 22 29 4 12 19 26 3 10 17 24 31 7 14 21 28 March April May June First day of week of onset Interpretation: The source of infection is persisting and continues to cause cases 11 CDC for TPP
  • 12. December November Reports October Interpretation: There is a seasonality in the end of the year and a trend towards September August July 2004 District, West Bengal, India, 2000-2004 June May Malaria in Kurseong block, Darjeeling April March February January December November October September August July 2003 June May increasing incidence year after year Incidence rates for analysis over a longer time period April March February January December November October September August July 2002 June Months May April March February January December November 12 October September August Incidence of Pf malaria July 2001 Incidence of malaria June May April March February January December November October September August July 2000 June May April March February January 5 0 45 40 35 30 25 20 15 10 Incidence of malaria per 10,000
  • 13. 2. Present the results of the analysis by place using a MAP • Number of cases  Spot map  Does not control for population size  Concentration of dots may represent high population density only  May be misleading in areas with heterogeneous population density (e.g., urban areas) • Incidence rates  Incidence rate map  Controls for population size 13 CDC for TPP
  • 14. Incidence by area Incidence of acute hepatitis (E) by block, Hyderabad, AP, India, March-June 2005 Attack rate per 100,000 population 0 1-19 20-49 50-99 100+ Open drain Interpretation: Blocks with hepatitis are those supplied by pipelines Pipeline crossing open sewage drain 14 crossing open sewage drains
  • 15. 3. Present the results of the analysis per person using an incidence TABLE • Distribution of cases by:  Age  Sex  Other characteristics (e.g., ethnic group, vaccination status) • Incidence rate by:  Age  Sex  Other characteristics 15 CDC for TPP
  • 16. Incidence according to a characteristic Probable cases of cholera by age and sex, Parbatia, Orissa, India, 2003 Number of cases Population Incidence Age group 0 to4 6 113 5.3% (In years) 5 to14 4 190 2.1% 15 to24 5 128 3.9% 25 to34 5 144 3.5% 35 to44 6 129 4.7% 45 to54 4 88 4.5% 55 to64 8 67 11.9% > 65 3 87 3.4% Sex Male 17 481 3.5% Female 24 465 5.2% Total Total 41 946 4.3% Interpretation: Older adults and women are at increased risk of cholera 16 CDC for TPP
  • 17. Distribution of cases according to a characteristic Immunization status of measles cases, Nai, Uttaranchal, India, 2004 19% 81% Immunized Unimmunized Interpretation: The outbreak is probably caused by a failure to vaccinate CDC for TPP
  • 18. Seven reports to be generated 1. Timeliness/completeness 2. Description by time, place and person 3. Trends over time 4. Threshold levels 5. Compare reporting units 6. Compare private / public 7. Compare providers with laboratory 18 Reports
  • 19. Report 1: Completeness and timeliness • A report is considered on time if it reaches the designated level within the prescribed time period  Reflects alertness • A report is said to be complete if all the reporting units within its catchment area submitted the reports on time  Reflects reliability 19 Reports
  • 20. Report 2: Weekly/ monthly summary report • Based upon compiled data of all the reporting units • Presented as tables, graphs and maps • Takes into account the count, divide and compare principle:  Absolute numbers of cases, deaths and case fatality ratio are sufficient for a single reporting unit level  Incidence rates are required to compare reporting units 20 Reports
  • 21. Report 3: Comparison with previous weeks/ months/ years • Help examine trend of diseases over time • Weekly analysis compare the current week with data from the last three weeks  Alerts authorities for immediate action • Monthly and yearly analysis examine:  Long term trends  Cyclic pattern  Seasonal patterns 21 Reports
  • 22. Report 4: Crossing threshold values • Comparison of rates with thresholds • Thresholds that may be used:  Pre-existing national/international thresholds  Thresholds based on local historic data • Monthly average in the last three years (excluding epidemic periods)  Increasing trends over a short duration of time (e.g., Weeks) 22 Reports
  • 23. Report 5: Comparison between reporting units • Compares  Incidence rates  Case fatality ratios • Reference period  Current month • Sites concerned  Block level and above 23 Reports
  • 24. Report 6: Comparison between public and private sectors • Compare trends in number of new cases/deaths  Incidences are not available for private provider since no population denominators are available • Good correlation may imply:  The quality of information is good  Events in the community are well represented • Poor correlation may suggest:  One of the data source is less reliable 24 Reports
  • 25. Report 7: Comparison of reports between the public health system and the laboratory Elements to compare Public health system Laboratories Validation of •Number of cases •Number of laboratory reporting seen by providers diagnoses Water borne •Cases of diarrheal •Water quality disease diseases Vector borne •Cases of vector •Entomological data disease borne diseases 25 Reports
  • 26. Making sense of different sources of information (“S” and “P” forms)  It is not possible to mix data from different case definitions  One cannot add cases coming from “S” and “P” forms (syndromic and presumptive diagnoses)  It is not possible to add apples and oranges  Use the different sources of information to cross validate (or “triangulate”)  If there is an increase in the cases of dengue in the “P” forms, check if there is a surge in the number of fever cases in the “S” forms 26 Interpretation
  • 27. What computers cannot do Skills Attitudes • Contact reporting units • Looking for missing information • Thinking • Interpret laboratory tests • Discussing • Make judgment about: • Taking action  Epidemiologic linkage  Duplicate records  Data entry errors • Declare a state of outbreak 27 Interpretation
  • 28. Expressed concerns versus reality Concerns Mistake commonly commonly expressed observed • Statistics are difficult • Data are not looked at • Multivariate analysis is complex • Presentation of data is challenging 28 Interpretation
  • 29. Review of analysis results by the technical committee • Meeting on a fixed day of the week • Search for missing values • Validity check • Interpretation of the analysis bearing in mind  The strength and weakness of data  The disease profiles  The need to calculate rates before comparisons Meeting on a fixed day of every week • Summary reports for dissemination • Action 29 Interpretation
  • 30. Take home messages 1. Link data collection and program implementation • Data > Information > Action 1. Count, divide and compare for time, place and person description 2. Share information through reports 3. Interpret with the technical committee to decide action on the basis of the information 30

Notes de l'éditeur

  1. Few ice breaking questions. Do not spend too much time.
  2. Outline of the session.
  3. You can connect this slide to the one we showed earlier in the course. We worked on the data collection side before. No we are working on analysis to transform data into information.
  4. This is the difference between data and information. The process between the two is analysis, or data reduction.
  5. The major concept behind epidemiological data analysis is CDC- Count, Divide and Compare. This slide was shown earlier. It is a revision.
  6. This exercise is to help the participants understand the denominator they need to work with. Sometimes, people have a hard time identify the denominator they need to use before a comparison. So In this exercise, by comparing the incidence of diphtheria among people below and under the poverty line, we will help participants understand the denominator they need to work with. Ask the participants what they should COUNT, denominator they would use to DIVIDE and what they would COMPARE (Answers on next slide).
  7. Answers to the questions on the previous slide. Try to understand the misconceptions among participants who did not identify the right denominator. That will help you understand your audience.
  8. The CDC process will be repeated three times for the three basic types of epidemiological analyses. Time Place Person
  9. For time, we use graphs. We can either use direct numbers or rates, depending on whether a comparison is needed.
  10. For this outbreak of a short duration, the population does not have time to change substantially. We can use the absolute numbers.
  11. In contrast, here, for a five year analysis, the population size increased so we need to divide by the denominators to allow comparison (CDC).
  12. Now we will discuss maps. These slides repeat the lectures on graphs, tables and maps. Make sure that people have the reflex of using maps to present the information by geographical area. It is too common to see it in tables, which constitutes a loss of information.
  13. This is an example of a map of analysis by geographical area. Ask the participants what were the step that were followed to prepare this map.
  14. For the third type of analysis, by person, we usually report the data in tables.
  15. That is the table to remember and to replicate when doing surveillance data analysis.
  16. This graph present more information about the person (I.e., immunization status).
  17. In the context of IDSP, we routinely prepare seven different types of reports.
  18. First is about completeness and timeliness.
  19. Second is the weekly / monthly summary report.
  20. Third is on trends.
  21. Fourth is about crossing threshold values.
  22. Fifth is about comparing reporting units.
  23. Sixth compares the private and the public sector.
  24. Seventh compare the results of the reporting in the pubic health care system and the laboratory.
  25. Some people may be confused about the way we examine data with information collected using different case definition from different reporting sources. Because the case definitions are different, we cannot simply add. But we can look synoptically at both types of reporting to see if trends emerge.
  26. Computer can help as tools but do not replace thinking.
  27. Epidemiologist may be inhibited by all kind of technical considerations. But often they have not even started to look at the data. Once there is a willingness to look at the data, the technical hurdles can be addressed.
  28. After analysis we have gone from data to information. Now, beyond that stage, the information needs to be INTERPRETED to decide on any relevant action. This interpretation for decision making should take place in the context of a technical committee.
  29. The take home messages of the session.