Myelodysplastic syndromes

2. Myelodysplasia : from marrow failure to malignant transformation Ahmed Elshebiny, MD University of Menoufyia

3. Blood is continuously renewed

4. The Bone Marrow is the blood Factory May be exposed to damage or failure

7. Bone Marrow Failure Syndromes Bone Marrow Failure Syndromes AA PNH MDS Acquired Constitutional Autoimmune Fanconi DC Diamond-Blackfan others Toxic, Irradiation, Infection Pure Red Cell Aplasia Agranulocytosis

9. Venn Diagram AML APLASTIC ANEMIA MDS PNH

10. Bone Marrow Failure Syndromes

11. Hematology lectures Myelodysplasia

13. Dysplastic erythroid maturation (dyserythropoiesis) Normal Dyserythropoiesis

19. Cytogenetic abnormalities in MDS

23. FAB classification of MDS

28. Ring sideroblasts

29. Aplastic Anemias Aplastic Anemias Acquired Conistituitional Single line Agranulocytosis Pure Red Cell Aplasia Multilineage

31. Aplastic Anemia

39. Bone marrow aspiration and biopsy

41. P.N.H

46. THANK YOU