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Case Report
Simultaneous Renal Cell Carcinoma and Giant
Retroperitoneal Liposarcoma Involving Small Intestine
Aleksandr A....
2 Case Reports in Surgery
Figure 1: Abdomen CT scan with IV and PO contrast, axial view.
Large multilobular mass (red arro...
Submit your manuscripts at
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Stem Cells
InternationalHindawi Publishing Corporation
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Simultaneous Renal Cell Carcinoma and Giant

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Simultaneous Renal Cell Carcinoma and Giant

  1. 1. Case Report Simultaneous Renal Cell Carcinoma and Giant Retroperitoneal Liposarcoma Involving Small Intestine Aleksandr A. Reznichenko Division of Transplant Surgery, Department of Surgery, University of Cincinnati, 231 Albert Sabin Way, Suite 1555, Cincinnati, OH 45267-0519, USA Correspondence should be addressed to Aleksandr A. Reznichenko; areznik9@yahoo.com Received 23 May 2016; Accepted 25 July 2016 Academic Editor: Robert Stein Copyright © 2016 Aleksandr A. Reznichenko. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. The concomitant occurrence of a renal cell carcinoma and retroperitoneal sarcoma is extremely rare with only few cases being reported. Methods. We present a case of simultaneous renal cell carcinoma and exceptionally large size retroperitoneal sarcoma involving small intestine. Surgical resection of retroperitoneal sarcoma and simultaneous right nephrectomy were performed. Results. Patient developed recurrent and metastatic disease and underwent debulking surgery following by chemotherapy. Despite aggressive behavior of the retroperitoneal sarcomas, patient is currently (7 years after simultaneous resection and nephrectomy) recurrence-free. Conclusions. Complete surgical resection is the mainstay of therapy for both renal cell carcinoma and retroperitoneal sarcoma. We present a case of simultaneous renal cell carcinoma and exceptionally large size retroperitoneal sarcoma. Debulking surgery and chemotherapy were helpful in our case. 1. Case Presentation A 61-year-old woman with history of morbid obesity, open cholecystectomy, and sarcoma excision from right lower extremity and from left buttock (6 and 3 years ago, resp.) developed fatigue, abdominal pain, and large palpable mass occupying entire abdomen and right flank. A computer tomography (CT) scan showed 27 × 20 cm multilobular abdominal mass and 2.5 × 2.5 cm solid mass in the middle pole of the right kidney (Figures 1 and 2). Laboratory data was unremarkable, and serum creatinine was 0.7 mg/dL. Patient underwent exploratory laparotomy, resection of large retroperitoneal tumor (weight 5621 gm) en block with small intestine (Figure 3), and primary small bowel to small bowel anastomosis. The mass in right kidney was resected and sent for frozen section, which revealed a malignant neoplasm of uncertain etiology. Right nephrectomy was performed. Final pathology showed renal cell carcinoma and myxoid liposarcoma involving small bowel and mesentery, with clear resection margins. Patient had uneventful recovery. Eight months later, the patient developed intraperitoneal recurrence of sarcoma and underwent debulking surgery. Subsequently, she developed recurrent and metastatic disease involving spleen, mesentery, liver, pelvis, and lungs and received multiple courses of chemotherapy, including Gemcitabine, Taxotere, and a clinical trial of Yondelis. Fol- lowing the chemotherapy treatment described above, the patient had near complete resolution of all intra-abdominal and pulmonary nodules and currently (7 years after resection of retroperitoneal mass and nephrectomy) is recurrence- free. Liposarcoma is one of the most common soft tissue sarco- mas found in adults. It has a predilection for retroperitoneal space. Renal cell carcinoma is the most common tumor of the kidney [1]. Patients with primary malignant fibrous histiocytoma demonstrate a risk for developing a renal cell carcinoma [2]. The concomitant occurrence of a renal cell carcinoma and retroperitoneal sarcoma is extremely rare with only few cases being reported [3, 4]. Surgical resection is the mainstay of therapy for both renal cell carcinoma and retroperitoneal sarcoma [1, 3, 4]. This case is noticeable because of the good outcome in our patient despite extremely aggressive behavior of the tumor Hindawi Publishing Corporation Case Reports in Surgery Volume 2016,Article ID 6021909, 2 pages http://dx.doi.org/10.1155/2016/6021909
  2. 2. 2 Case Reports in Surgery Figure 1: Abdomen CT scan with IV and PO contrast, axial view. Large multilobular mass (red arrow). Figure 2: Abdomen CT scan with IV and PO contrast, axial view. Solid mas in the right kidney (red arrow). Figure 3: Surgical specimen: large retroperitoneal sarcoma involv- ing small bowel and mesentery. and also because of exceptionally large size of retroperitoneal sarcoma. Competing Interests The author declares that they have no competing interests. References [1] S. Hoshi, N. Hayashi, M. Yagi et al., “Long term survival in a case of concurrent retroperitoneal liposarcoma and renal cell carcinoma: a case report,” BMC Research Notes, vol. 7, article 538, 2014. [2] O. Merimsky, Y. Kollender, J. Issakov et al., “Multiple primary malignancies in association with soft tissue sarcomas,” Cancer, vol. 91, no. 7, pp. 1363–1371, 2001. [3] J. M. Williamson, T. C. K¨onig, and R. Canelo, “Incidental finding of renal cell carcinoma in recurrent retroperitoneal liposarcoma,” Annals of the Royal College of Surgeons of England, vol. 90, no. 1, pp. W4–W5, 2008. [4] Y. Kinebuchi, O. Ishizuka, T. Minagawa, O. Nisizawa, and H. Shimojo, “Concurrent perirenal liposarcoma associated with renal cell carcinoma,” Acta Urologica Japonica, vol. 55, no. 9, pp. 571–574, 2009.
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