Despite ongoing controversies, the evidence is clear: Some brain training interventions (in a broad definition, including cognitive training, virtual reality and brain stimulation) work, and some don’t. What explains the difference? What conditions maximize the probability of transfer into real-life benefits? Understanding these conditions, as outlined in The SharpBrains Guide to Brain Fitness, is crucial to separate wheat from chaff.
- Chair: Dr. Peter Whitehouse, Professor of Neurology at Case Western Reserve University
- Alvaro Fernandez, CEO & Co-Founder of SharpBrains
- Dr. Bruce E. Wexler, Professor of Psychiatry at Yale University
- Dr. Roy Hamilton, Assistant Professor in Neurology at the University of Pennsylvania
Presentation @ The 2015 SharpBrains Virtual Summit http://sharpbrains.com/summit-2015/agenda
2. Under what conditions does
brain training work?
Chaired by: Dr. Peter Whitehouse,
Professor of Neurology at
Case Western Reserve University
Alvaro Fernandez,
CEO & Co-Founder of SharpBrains
Dr. Bruce E. Wexler,
Professor of Psychiatry
at Yale University
Roy Hamilton,
Assistant Professor in
Neurology at the
University of Pennsylvania
11. Five conditions to maximize transfer
To maximize real-world value of training…
1. Target neural processes that support real-world
activities
2. Minimum “dose” of ~15 hours of training per
targeted improvement
3. Address an individual’s bottleneck/ deficit
4. Adaptive challenge
5. Continued practice
Source: The SharpBrains Guide to Brain Fitness
What does the “BBC brain training study” (2010, 2015)
prove?
13. Conditions Under Which Brain
Training Works
Bruce E. Wexler
Professor of Psychiatry, Yale University
Founder and Chief Scientist, C8 Sciences
14. Conditions Under Which Brain Training Works
• Clear neurocognitive target for training
– For diseases, you must understand the pathology
– For enhancing normal function, you must have a
consistent neural system target
• Effective training program
– Multi-dimensional and systematic
– Sophisticated data-driven individualization of
training
– Good training schedule: dose, duration, frequency
• Engaged users
16. • Pre-identified neurocognitive dysfunction
associated with failure to respond to medication
– Cognitive executive dysfunction
– Hypo-activation on fMRI stroop paradigm in dorsal ACC (BA 24/32),
superior prefrontal cortices (BA 6), and the middle frontal gyrus
• Rx trial in 11 pts who had failed to respond at all to
12 weeks of supervised medication
• 8/11 met criteria for remission (MADRS < 11) in 4
weeks, one more met criteria in 6 weeks, one did not
reach remission and one dropped out
Neuroplasticity-based computerized cognitive remediation for
treatment resistant geriatric depression
Morimoto SS, Wexler BE, Liu J, Hu W, Seirup J, Alexopoulos GS
Nature Communications: August 5, 2014
17. • Executive Functions Improved
– Stroop color word, p = .014
– Trails B, p = .024
– Design Fluency (Delis Kaplan EF System), p = .002
– Semantic Clustering (Mattis Dementia Rating), p =.052
• Verbal WM did not improve
• Improvement on Trails B was correlated with
improvement on the MADRS, spearman r = .72, p = .018.
Neuroplasticity-based computerized cognitive remediation for
treatment resistant geriatric depression
Morimoto SS, Wexler BE, Liu J, Hu W, Seirup J, Alexopoulos GS
Nature Communications: August 5, 2014
18. Group: F(1,49.2)=0.019, p=0.892
Week: F(1,71.2)=30.97, p<0.0001
Group*Week: F(1,61.8)=5.32, p=0.024
Lexipro group: historical controls, unselected for prior failure to respond to treatment
Neuroplasticity-based computerized cognitive remediation for
treatment resistant geriatric depression
Morimoto SS, Wexler BE, Liu J, Hu W, Seirup J, Alexopoulos GS
Nature Communications: August 5, 2014
19. Neural System that Supports Executive Functions
Sustain Attention, Resist Distraction, Category Use, Emotion Regulation, Memory, Flexibility
Inattention, Distractibility, Impulsivity, Decreased Memory, Rigidity, Limited Categorizing
Multi-Dimensional Brain Training for Depression
Neuropathology
20. Memory Training
• Memory function is affected by factors along multiple
dimensions
– Number of things to remember
– Study time, inter-stimulus interval, retention interval
– Similarity of things to remember to each other and to things in recent
memory
– Distraction during encoding, maintenance or recall
– Requirement to manipulate the information in memory
• Many memory training games only train recall of
increasingly long lists of things. These are likely to
improve function in only limited ways in limited
situations.
• With a more complex and multidimensional training, a
new problem arises: when to move a user from training
along one dimension to training along another?
21.
22.
23. List Sorting WM test from NIH Toolbox: Children are shown pictures of animals or furniture and
have to report them back in order from smallest to largest. If they get 2 correct, they are shown
3, then 4, etc; score is total correct. After Activate all grades are above Fall score of next grade.
24. Enhancing brain training with electrical stimulation:
Promises and perils
Roy Hamilton, MD, MS
Assistant Professor of Neurology & Physical
Medicine & Rehabilitation
Director, Laboratory for Cognition & Neural
Stimulation (LCNS)
University of Pennsylvania
NO RELEVANT DISCLOSURES
28. 9-Volt Nirvana
“Zap your brain into the zone: Fast track to pure focus”
New Scientist, 2012
Is Sally right?
29. 9-Volt Nirvana
“Zap your brain into the zone: Fast track to pure focus”
New Scientist, 2012
Is Sally right?
What if she is? What if she isn’t?
30. 9-Volt Nirvana
“Zap your brain into the zone: Fast track to pure focus”
New Scientist, 2012
Is Sally right?
What if she is? What if she isn’t?
What else do we need to think about?
34. Transcranial Direct Current Stimulation
(tDCS)
• Subthreshold
stimulation
• Neurons alter firing
rates
• Anodal or cathodal
stimulation may
have different
effects.
38. Transcranial Direct Current Stimulation
(tDCS)
• No known serious
adverse side-effects
• Portable
• Can be worn during
other therapies
39. Transcranial Direct Current Stimulation
(tDCS)
• No known serious
adverse side-effects
• Portable
• Can be worn during
other therapies
• Costs ranging from
$100s-$1000s
40. Transcranial Direct Current Stimulation
(tDCS)
• No known serious
adverse side-effects
• Portable
• Can be worn during
other therapies
• Costs ranging from
$100s-$1000s
• Usable without
advanced training
54. Conclusions
• Neither snake oil nor
panacea
• Potential for a different
kind of harm/risk?
• Different research
(mechanisms &
mechanics) needed
55. Conclusions
• Neither snake oil nor
panacea
• Potential for a different
kind of harm/risk?
• Different research
(mechanisms &
mechanics) needed
56. Conclusions
• Neither snake oil nor
panacea
• Potential for a different
kind of harm/risk?
• Different research
(mechanisms &
mechanics) needed
57. Follow us on Twitter @PennMedLCNS
LCNS email: braintms@mail.med.upenn.edu
LCNS website: http://www.med.upenn.edu/lcns
Faculty
Roy Hamilton, MD, MS
H. Branch Coslett, MD
Sudha Kessler, MD
Research Staff
Olufunsho Faseyitan, MS
Daniela Sacchetti
Juliann Purcell
Nicole White
Quan Wan
Postdoctoral Fellows
Rachel Wurzman, PhD
Denise Harvey, PhD
John Medaglia, PhD
Perelman School Of Medicine
Catherine Norise
Daniel Cristancho
Penn School of Nursing
Darina Petrovsky, MSN
Undergraduates
Jonathan Muruakuo
Joely Mass
Students
Special thanks to Martha Farah, PhD, Anna Wexler,
and the Penn ELSIs of NBS Focus Group