dsattri592@gmail.com

1. By :-
Mr. Dinesh Sharma
M Pharma(2nd
sem)
dsattri592@gmail.com
GUIDE LECTURER :-
Miss. Japinder kaur
M Pharmacist
Global College of
Pharmacy

2.  Introduction
 Plant layout
 Aspects

3.  Designed according to GMP practices which
ensures …….
 Prevention of cross contamination
 Proper air handling systems.
 Proper cleaning & sanitary facilities.
 Proper Lighting
 Proper Plumbing
 Proper washing etc.

4. Layout:
It is the organized properly planned
INTERDEPARTMENT and INTRADEPARTMENT
arrangements.
PROPER LAYOUT:
Increases productivity
 Helps in proper utilization of - MAN
- MATERIAL
- MONEY
- MACHINES

5. 
layout With
1) crossover traffic
2) circular flow
3) Parallel flow

6. Area :
60+20
sq.meter
Deduster
30+10
sq.meter
30 Pascal
10 Pascal
20 Pascal
15 Pascal
15 Pascal
Temp. 25+/-5
Humidity :
55+/-
10%RH
CROSS OVER TRAFFIC

7. Area:60+20sq.meter
Temp.
25+/-5
Humidity :
55+/-
10%RH
30+10
sq.meter
Circular flow

8. Parallel flow

9. For Uncoated Tablet
For Coating
Section
For Basic Installation
Sq.mtrs.
For Ancillary Area
Sq.mtrs.
60
30
20
10
AREAAREA REQUIREMENTREQUIREMENT
ENVIRONMENTENVIRONMENT REQUIREMENTREQUIREMENT
Temperature : 25 ± 5 C
Humidity : 55 ± 10 %RH
Pressure in Ware House Area: 10 Pascal
Pressure in Weighing Area : 20 Pascal
Pressure in Tableting Area : 15 Pascal
Pressure in Central Corridor : 30 Pascal

10.  Proper maintenance is required for :-
o Product Protection
o Employee Comfort
o Controlled Process Parameters

11. Name of Area Pressure
maintained in
pascals
Warehouse 10
Weighing area 20
Tableting area 15
Central corridor 30

12.  Low humidity for Effervescent tablets & moisture
sensitive drugs.
 Presure with areas like mixing & tableting area
should remain on negative side than central
corridor.
 All area should be free from dust & floating
particles , if possible air conditioned .
 In coating section suitable exhaust systems.
 There should be properly organized & working
air handling system to supply purified air.

13.  Temp control & Air control should be such be
that there should be comfortable working
environment.
 And no impact on characteristics of in-process
materials such as granulation, raw materials.
 All areas should be properly ventilated.