Plasma proteins

1. Ayesha Tariq / Roll N0#19
Plasma Protein

2. Plasma Protein:-
Total Plasma Protein:-
6 . 3 - 7 . 9 g m / d L ( A v e r a g e 7 . 0 g m / d L )
(A). Albumin:- 3 . 7 - 5 . 3 g m / d L
(B). Globulins:- 1 . 8 - 3 . 6 g m / d L
Albumin - Globulin Ratio:- 1 . 2 t o 2 . 5

3. Variation of Total Plasma Proteins.
Dehydration.
(A).
(B).
intake OR Endogenous synthesis
Loss
GIT- Enteropathies
Urine- Renal disease
Skin Burns

4. Albumin:-
Normal conc: 3 . 7 - 5 . 3 g m / d L .
Normal Functions:-
1. Plasma oncotic pressure
2. Regulation of E/C fluid volume.(Plasma Volurme)
3. Transport – bilirubin Cortisol
Fatty acids T3
urates Iron
Calcium
Drugs
4. Source of Amino acids
5. Nutritional functions

5. VARIATION IN ALBUMIN Conc:-
Increase in albumin conc Dehydration Vomiting Diarrhea.:-
DECREASE IN ALBUMIN CONC.
(A). Decrease in availability:
intake in the food
synthesis Liver disease
Impaired absorption Malabsorption
Catabolism fever

6. B. Increased Loss:-
1. In urine Nephrotic syndrome
2. GIT Malabsorption.
3. Skin Burns.
Clinical presentation of hypoalbuminemia.
-Oedema (oncotic pressure)

7. Globulins:-
Alpha 1 0 . 3 - 0 . 5 g m / d L
Alpha 2 0 . 5 - 0 . 7 g m / d L
Beta 0 . 6 - 1 . 2 g m / d L
Gamma 0 . 9 - 1 . 5 g m / d L

8. Alpha 1 Globulins:-
1. Alpha 1_Antitrypsin_inhibitor of proteolytic enzymes
Trypsin, Plasmin and Thrombin
2. Transcortin
3. Thyroxin binding globulins.
4. Alpha - fetoproteins.

9. Alpha 2 Globulins:-
- Alpha 2 Macroglobulins
- Haptoglobins
- Ceruloplasmin

10. Beta Globulins:-
- Transferrin
- Hemopexin
- Beta Lipoproteins
Gamma Globulins:-
- Immuno Globulins G, A, M, D, E.

11. Thank You!