2. Disclaimer
This presentation may contain forward-looking statements based on current
assumptions and forecasts made by Bayer Group or subgroup management.
Various known and unknown risks, uncertainties and other factors could lead to
material differences between the actual future results, financial situation,
development or performance of the company and the estimates given here.
These factors include those discussed in Bayer’s public reports which are
available on the Bayer website at www.bayer.com.
The company assumes no liability whatsoever to update these forward-looking
statements or to conform them to future events or developments.
• Bayer Investor Presentation • Meet Management • June 2014Page 2
3. Page 1
Our Mission –
Innovation and Customer Value
Bayer is an innovation company
With a strong “innovation portfolio”
Addressing new growth areas
Capable of identifying and using
breakthrough innovations
Bayer is innovative in many ways:
Products, technologies, processes,
business models, strategies
Bayer products improve
the quality of people’s lives
Bayer has an excellent understanding
of human, animal and plant health,
as well as of high-quality materials
Respect for people and nature
is an essential part of our values
Science / Innovation Better Life
Science For A Better Life
• Bayer Investor Presentation • Meet Management • June 2014
4. Page 2
Our Business Portfolio –
Leading in Its Markets
Break-down excluding reconciliation
Sales 2013: €40.2bn
CropScience
Chemical crop protection & biologicals
global #2, seeds & traits
€8.8bn
MaterialScience
Polyurethanes and polycarbonates,
global #1/2
€11.2bn
HealthCare
Pharmaceuticals €11.2bn,
leading positions in core indications
Consumer Health €7.7bn,
OTC #2, blood glucose meters #3, Animal
Health #5, contrast media #1
€18.9bn
23%
29%
48%
• Bayer Investor Presentation • Meet Management • June 2014
5. We Generate Almost 90 Percent of our
Earnings in the Life Sciences Businesses
Page 3
*EBITDA before special items
23%
29%
45%
88% 12%
Sales 2013 Adj. EBITDA 2013*
Human
Health
3%
Breakdown excluding Reconciliation
Material
Science
Plant Health
Animal
Health
Life
Sciences
Material
Science
• Bayer Investor Presentation • Meet Management • June 2014
6. • Bayer Investor Presentation • Meet Management • June 2014Page 4
2010-2013 –
A Period of Significant Success
Delivered growth and performance
Unprecedented R&D productivity
Pharma launch product sales ahead of expectations
Executing successfully our OTC growth strategy
CropScience customer-centric strategy bearing fruit
Capital discipline at MaterialScience
7. 2010-2013 – A Period of Significant Progress
Page 5
2010 2011 2012 2013
35.1
36.5
39.7 40.2
7.1
7.6
8.3 8.4
Sales 5%
Core EPS 10%
Adj. EBITDA 6%
4.19
4.83
5.30
5.61
Sales and adjusted EBITDA in € billion, core EPS in €
CAGR 2010-2013
• Bayer Investor Presentation • Meet Management • June 2014
8. Page 6
EBIT
in € million
+18%
2,096
1,771
Sales
in € million
% currency & portfolio adj.
+8%
10,55510,266
EBITDA
adjusted*
in € million
+12%
2,738
2,453
Core EPS
in €
+15%
1.95
1.70
*before special items
Q1’14Q1’13 Q1’14Q1’13 Q1’14Q1’13 Q1’14Q1’13
Strong Momentum Continued in Q1 2014
Despite Significant Currency Headwind
• Bayer Investor Presentation • Meet Management • June 2014
9. FY 2014 Group Guidance Maintained –
Targeting Further Sales and Earnings Growth
Page 7
2013 2014E*
Sales €40.2bn
~5% to
~€41-42bn
(neg. FX effect approx. -2%)
adj. EBITDA €8.4bn
low- to mid-single-
digit % increase
(neg. FX effect approx. -5%)
core EPS €5.61
mid-single-digit %
increase
(neg. FX effect approx. -6%)
Sales ∆ Fx and portfolio adjusted, EBITDA before special items
*Assuming average Fx rates of Q4’13 (USD 1.36)
Outlook depends on specific planning assumptions as detailed in the Annual Report• Bayer Investor Presentation • Meet Management • June 2014
10. Page 8
2013 Sales CAGR 2016e
Pharma: Maximize Value of
Launch Products
• Bayer Investor Presentation • Meet Management • June 2014
11. 24 Successful Phase III Clinical Trials
at Pharma since 2010
Page 9
Various indications incl. treatment of deep vein thrombosis/pulmonary
embolism, stroke prevention in atrial fibrillation and secondary prevention
of acute coronary syndrome
Wet age-related macular degeneration, diabetic macular edema, myopic
choroidal neovascularization and central retinal vein occlusion
Metastatic colorectal cancer and metastatic gastrointestinal stromal tumors
Metastatic castration-resistant prostate cancer with symptomatic bone
metastases
Pulmonary arterial hypertension and chronic thromboembolic
pulmonary hypertension
Radioactive iodine refractory differentiated thyroid cancer
Prophylaxis in hemophilia A: Site-specific PEGylated Factor VIII with
5- or 7-days dosing intervals
• Bayer Investor Presentation • Meet Management • June 2014
BAY 94-9027
Major examples
12. Launch Products Drive Growth at Pharma
• Bayer Investor Presentation • Meet Management • June 2014Page 10
Sales in € billion; ∆% Fx & portf. adjusted
Pharma Sales / Launch Products Launch Products 2013
2010 2011 2012 2013
10.0 1.5
25%
949
197
333
3
41
Sales in € million
9.9
10.8
11.2
+1%
+4%
+9%
13. Launch Products Expected to Contribute
~€2.8bn to Pharma Sales in 2014
• Bayer Investor Presentation • Meet Management • June 2014
Executing >100 launch events* in
2014
Continuous R&D investments in
life-cycle management
Increased marketing and sales
investments in emerging markets
Incremental marketing and R&D
investments of €0.5bn in 2014e
* new indications and new countries
Page 11
14. Page 12
Pharma – Peak Sales Potential of Launch
Products was Raised in February to ≥€7.5bn
Continued successful launch exe-
cution and life cycle management
Unchanged
Unchanged
Unchanged
~€3.5bn
≥€1.5bn
≥€1bn
≥€1bn
≥€0.5bn
>€2bn
≥€1bn
Old Current
• Bayer Investor Presentation • Meet Management • June 2014
Continued successful launch exe-
cution and life cycle management
15. Two Recent Steps Forward for Bayer’s
Pharma Business
• Bayer Investor Presentation • Meet Management • June 2014
Acquisition of
Algeta
Strategic Pharma
sGC Collaboration
with Merck
Full control over Xofigo
Comprehensive life-cycle management program,
including studies in earlier settings of prostate
cancer, combination studies and other tumors
Complementing Bayer’s sGC franchise, including
Adempas, with Merck’s cardiovascular capabilities
Leverage joint development capability to fully explore
broad potential of sGCs
Building Bayer’s US presence in specialty pharma
while leveraging Merck’s US strength
Page 13
16. Pharma – Maximizing
the Value of Launch Products
Page 14
2013
Guidance
2014
Aspiration
2016
Sales Increase €11.2bn High-single digit %
(neg. FX effect approx. -2%)
8% CAGR
Adj. EBITDA Increase €3.5bn Low- to mid-single digit %
(neg. FX effect approx. -€150m)
Adj. EBITDA Margin 31.2% Level with prior year ≥33%
Assuming average FX rates of Q4‘13 (USD 1.36)
Sales ∆ % Fx & portf. adjusted, margin = EBITDA before special items to sales
• Bayer Investor Presentation • Meet Management • June 2014
17. • Bayer Investor Presentation • Meet Management • June 2014Page 15
Aspire to Become the Leading
OTC Company
18. • Bayer Investor Presentation • Meet Management • June 2014Page 16
Portfolio of some of the world’s most
recognized brands
Outperforming market growth in past
7 out of 8 years
Successful expansion in EM focus
markets, China, Brazil, and Russia
Selected bolt-on acquisitions in key
countries: Steigerwald, Germany &
Dihon, China
Acquisition of Merck’s Consumer
Care business – a major step
towards OTC leadership
3.4
3.5
3.9 3.9
2010 2011 2012 2013
+5%
+7%
+6%
Consumer Care sales in € billion; ∆% Fx & portfolio adj.
*planned acquisition, closing expected in H2 2014
Successfully Executing OTC Growth Strategy
19. • Bayer Investor Presentation • Meet Management • June 2014Page 17
Acquisition of Merck’s Consumer Care
Business Makes us #2 Globally and #1 in US
Highlights
$14.2bn investment, all cash, fully
debt financed
Complementary portfolio offering scale
in key categories and optimized
geographic footprint
Full trademark ownership for Claritin
Market Positioning 2013*
*Pro-forma OTC sales 2013; after allowing for the Novartis/Glaxo deal and Bayer/Merck transaction;
CC: Consumer Care
in € billion
20. Combination Offers Significant Synergy
Potential
• Bayer Investor Presentation • Meet Management • June 2014Page 18
Cost synergies of ~$200m p.a. by 2017
Tax benefits from year 1
Asset purchase with significant future tax savings
Savings in marketing costs
Savings in COGS, administration
Step-up of EBITDA margin pre-special items at Consumer Care
by ~1pp and core EPS accretion of 2% already in the first year
Revenue synergies of already ~$400m by 2017
Incremental US sales
Realize brand penetration opportunities ex-US
Revenue
Cost
Tax
21. Page 19 • Bayer Investor Presentation • Meet Management • June 2014
2013 Sales CAGR 2016e
CropScience: Further Growth at
Benchmark Profitability
22. Delivering Growth And Performance at
CropScience
6.8
7.3
8.4
8.8
2010 2011 2012 2013
2013 – the 3rd year in a row
delivering strong sales growth at
record margin
New product sales 2013 up 33% at
€1.5bn*
Strong start to 2014 season with
sales up 12%
Sales in € billion, ∆% Fx & portf. adjusted,
Adj. EBITDA margin in %
19.0
24.2
25.5
22.8
+9%
+12%
Page 20 • Bayer Investor Presentation • Meet Management • June 2014
Customer-centric strategy
bearing fruit
*Sales with Crop Protection products launched since 2006
+9%
23. Significant Contribution from New Crop
Protection Products
• Bayer Investor Presentation • Meet Management • June 2014Page 21
*Sales with Crop Protection products launched since 2006
1.1
1.5
1.8
2.6
2012 2013 2014e 2016e
+33%
Sales from new Crop Protection products
launched since 2006 in €bn
∆% y-o-y, () Fx adj.
Q1
0.6
(+16%) - Superior ‘all-in-one’
cereal fungicide with yield-boosting
effect
herbicide (+14%) -
Excellent weed control in corn and
cereals, also in case of glyphosate
resistance
(+75%) - Broad-spectrum
insecticide with fast, long-lasting
action
(+112%) - New fungicide now
available in several key markets
Q1 2014 Highlights
24. Significant Investments in our
Growth Platforms
• Bayer Investor Presentation • Meet Management • June 2014Page 22
BiologicalsSeeds
>€300m R&D investments p.a. to
support leadership positions in cotton
& oilseed and to develop position in
soybean and wheat
Further selected acquisitions to
strengthen portfolio and regional
setup, esp. in Latin America
Launch of first soybean brand
Credenz (2014e)
Launch of first wheat variety
(2015e)
Successful market entry with nematode
seed treatment Poncho/Votivo
(sales 2013: ~€150m)
Acquisition of AgraQuest, global provider
of innovative biological pest management
solutions
Acquisition of Prophyta, a provider of
well-established products, e.g. nematicide
BioAct
Acquisition of Biagro* adds nitrogen
inoculants & plant health promoters
*Subject to regulatory approvals
25. CropScience – Above Market Growth at
Benchmark Profitability
Page 23
2013
Guidance
2014
Aspiration
2016
Sales Increase €8.8bn Mid- to high-single-digit %
(neg. FX effect approx. -3%)
6% CAGR
Adj. EBITDA Increase €2.2bn Low-single-digit %
(neg. FX effect approx. -€150m)
Adj. EBITDA Margin 25.5% - 24-25%
Assuming average FX rates of Q4‘13 (USD 1.36)
Sales ∆ % Fx & portf. adjusted, margin = EBITDA before special items to sales
• Bayer Investor Presentation • Meet Management • June 2014
27. • Bayer Investor Presentation • Meet Management • June 2014Page 25
Macro-Economic Environment for
MaterialScience Likely to Improve
Oil price expected to stabilize in
2014 (budget of Ø $110 per bbl*)
Supply & demand balances of key
products improving with:
Long-term demand drivers
intact
Limited net new capacity to
come on stream
21%
18%
27%
19%
Automotive
(+4%)
Electro /
Electronic
(+6%)
Construction
(+4%)
Furniture
(+4%)
Others
(incl.
Chemicals)
15%
Sales by industry 2013 and expected 2014 growth
Key Customer Industries Outlook Additional Key Performance Drivers
*Ø 2013: $110 per bbl
29. MaterialScience – Asset Utilization and
Efficiency Measures to Drive Cash Returns
• Bayer Investor Presentation • Meet Management • June 2014Page 27
2013
Guidance
2014
Aspiration
2016
Sales Increase €11.2bn Mid-single-digit %
(neg. FX effect approx. -2%)
Volume growth
> global GDP
Adj. EBITDA Increase €1.1bn Increase
(neg. FX effect approx. -€50m)
-
CFROI vs. WACC 5.5% < 6.9% - CFROI > WACC
Assuming average FX rates of Q4‘13 (USD 1.36)
Sales ∆ % Fx & portf. adjusted, margin = EBITDA before special items to sales
30. Bayer –
Optimistic About Future Developments
Peak sales potential of new pharma products of ≥€7.5bn
Track record of performance:
Core EPS with 10% CAGR since 2010
Successful start to 2014 – full-year 2014 group guidance
maintained
Page 28
Successfully executing on OTC growth strategy
• Bayer Investor Presentation • Meet Management • June 2014
32. EBIT
in € million
+26%
4,934
3,928
Sales
in € million
% currency & portfolio adj.
+5%
40,15739,741
EBITDA
adjusted*
in € million
+1%
8,4018,280
Core EPS
in €
+6%
5.61
5.30
*before special items
FY’13FY’12 FY’13FY’12 FY’13FY’12 FY’13FY’12
FY 2013 – Encouraging Performance
Driven by Life Sciences
Page 30 • Bayer Investor Presentation • Meet Management • June 2014
33. FY 2013 –
Regional Performance
Page 31
Africa &
Middle East
Eastern
Europe
Emerging Economies
Emerging
Economies¹
+7%
Others²
+10%
USA
+4%
Western Europe
+2%
2013 Group Sales by Region
Group €40,157m; +5%
~5,100
+15%~5,800
+4%
~1,700
-1%~2,500
+7%
1: Emerging economies include: Latin America, Asia w/o Japan, Australia, New Zealand, Africa and Middle East incl. Turkey, Eastern Europe
2: Others = Japan, Australia, New Zealand, Canada; 3: Emerging Asia = Asia w/o Japan, Australia, New Zealand
In € million, ∆% yoy Fx adjusted
38%
10%
31%
21%
Latin
America
Emerging
Asia³
• Bayer Investor Presentation • Meet Management • June 2014
37. FY 2013 –
Cash Flow And Net Debt Development
Page 35
-€0.3bn 6.7
GCF oFCF
5,832
Invest-
ments
2,157 3,014
∆
y-o-y +28% +16%
NCF
5,171
+14% +12%
Dec 31, 2012 Dec 31, 2013
7.0
FY 2013 Cash Flow Net Debt Development
Cash Flow in € million, Net Debt in € billion
• Bayer Investor Presentation • Meet Management • June 2014
38. On Our Way to OTC Leadership
Investor Handout – Meet Management
Acquisition of Merck & Co.’s
Consumer Care Business
June 2014 – New York
39. Evolution of Bayer Consumer Care’s
OTC Business
2008
Acquisition of OTC brand
portfolio from Sagmel
(CEE) and Topsun (China)
1999
Aspirin trademark
centenary-worldwide
sales > €500m
1899
ASPIRIN introduced
as an over-the-counter
(OTC) medicine
1994
Consumer Care business group
created by the acquisition of North
American OTC business of Sterling;
Acquisition of the “Bayer Cross”
Trademark in USA
2005
Acquisition of Roche
Consumer Health
2013
Aspirin trademark sales
of >€900m
Acquisition of
Steigerwald (Germany)
Page 37 • Bayer Investor Presentation • Meet Management • June 2014
2014
Proposed acquisition of Merck’s
Consumer Care business (US)
Transaction agreement signed with
Dihon Pharmaceutical Group (China)
40. • Bayer Investor Presentation • Meet Management • June 2014Page 38
Growth Strategy
Maximize brand potential
Global expansion of key brands
Exploit our innovation pipeline
Grow in emerging markets
Increase commercial power
Bolt-on acquisitions to strengthen
portfolio & regional set-up
3.4
3.5
3.9 3.9
2010 2011 2012 2013
+5%
+7%
+6%
Consumer Care sales in € billion; ∆% Fx & portfolio adj.
Bayer Consumer Care – Outperforming
Markets in Past 7 Out of 8 Years
41. Merck’s Consumer Care Business Fits
Perfectly With Bayer Consumer Care
• Bayer Investor Presentation • Meet Management • June 2014
Complementary
Portfolio
Building on core
competencies
Creation of a global leader in OTC
Gaining scale in key categories CASF1, dermatology,
and gastrointestinal
Optimizing footprint in North America
Strong track record of growing OTC brands
Strong geographical presence to broaden Merck’s
portfolio globally
Utilizing integration skills from past transactions
Page 39
Acquisition criteria
fulfilled
Creating leadership positions in important consumer
care categories and geographies
Increasing consumer care margin2 by ~1pp from year 1
Immediate core EPS accretion from year 13
1 cold, allergy, sinus, flu; 2 EBITDA pre-special items;
3 transaction incl. sGC collaboration
42. Page 40 • Bayer Investor Presentation • Meet Management • June 2014
Combined Portfolio Significantly Strengthens
Global Positions
Gastrointestinal
Analgesics3
CASF2
Nutritionals
Dermatology1
Total
Others4
3,904 1,635 5,539
1,110 386
372 803
126 513
439 141
1,023
834
1 including sun care; 2 Cold, Allergy, Sinus, Flu; 3 including Cardio; 4 Foot Health, Women’s Health, Other
1,496
1,023
1,175
834
580
431
#1
#2
#3
#1
#2
Global position*2013 Sales in €m (pro-forma portfolio)
Note: Merck sales converted at average USD rate of 1.33 (FY 2013)
305
*After allowing for the Novartis/Glaxo deal; excluding Dihon acquisition in China; excluding Rx
MerckBayer
43. Page 41 • Bayer Investor Presentation • Meet Management • June 2014
Combined Portfolio Significantly Strengthens
Geographic Footprint
Note: Merck sales converted at average USD rate of 1.33 (FY 2013)
*After allowing for the Novartis/Glaxo deal; excluding Dihon acquisition in China; excluding Rx
Latin America
Europe
North America
Total
Asia/Pacific
3,904 1,635 5,539
1,117 1,105
1,621 170
389
513
141
777
2,222
1,791
946
580
#1
#1
#5
#2
Global position*2013 Sales in €m (pro-forma portfolio)
191
169
MerckBayer
44. FY 2013 sales in € million (∆% yoy Fx-adj.)
321
310
232
214**
207
176
158
257
*Total Aspirin includes Aspirin Complex and Aspirin Cardio (Rx)
**Total Alka-Seltzer includes Alka-Seltzer and Alka-Seltzer Plus
916*
= Rx Sales
Page 42 • Bayer Investor Presentation • Meet Management • June 2014
Combined Top 10 Portfolio –
Individual Brands with Annual Sales >€100m
576
Note: Merck sales converted at average USD rate of 1.33 (FY 2013); based on pro-forma FY 2013 net sales
45. • Bayer Investor Presentation • Meet Management • June 2014Page 43
Top Priorities To Be Executed Immediately
After Closing of Transaction…
Ensure fast integration into operations
Safeguard product supply
Realize synergy potential
Prioritize brand strategies within combined portfolio
Realize Merck brand penetration opportunities ex-US
Define and execute individual brand strategies
Develop US scale advantage
Strive for leadership with trade customers
Provide a broader product portfolio
Critical mass
in US
Brand Roll-
Out ex-US
Smooth
integration
46. • Bayer Investor Presentation • Meet Management • June 2014Page 44
Clear Strategy For a Smooth Integration
2014 Q2 2014 Q42014 Q3 2015 (End State)
Smooth integration expected due to experienced management team
• Ensure effective integration into Consumer Care
• Safeguard on-going product supply
• Prioritize and execute identified brand development / expansion strategies
• Ensure sufficient future capacity for growth
• Capitalize on Merck’s innovation capabilities
• Achieve scale and revenue synergies
• Capture consolidation and efficiency synergies by 2017
Deal signing Deal closing Consolidation / Integration
47. • Bayer Investor Presentation • Meet Management • June 2014Page 45
Enhanced Scale and Broader Category
Scope Improve Product Offerings
US Retail Sales CASF Benefits from Enhanced Scale
Co-promoting complementary
brands
New item assortment and shelving
opportunities
Improved merchandising efficiencies
Bigger and more impactful trade
events
Foster strategic partnerships with
retailers
FY 2013 retail sales in CASF in $ million*
$-
$200
$400
$600
$800
$1,000
$1,200
RB Bayer &
Merck
J&J Merck &
Co.
P&G Pfizer Chattem Bayer GSK
*Source: IRI; Latest 52WK; December 2013
Make Bayer Consumer Care Top Strategic Partner for US Retailers
48. Maximizing Brand Potential Through
Global Expansion
Brand Sales by Major Region 2013 Expansion Plans
• Bayer Investor Presentation • Meet Management • June 2014Page 46
Analgesic
~80% in North America
~95% in North America
Wound-healing
~75% in Europe
Anti-fungal
~75% in Europe & LatAm
Vitamins & minerals
~50% in Europe
~80% in North America
CASF
Sun Care
49. • Bayer Investor Presentation • Meet Management • June 2014Page 47
Russia
Country OTC Market
Sales Growth
2013*
Execution Plans
China
Global #2
Growing 2x the
global rate
Use investments in footprint, brand-building
and sales capabilities to extend Claritin
leadership
Build sun care category with Coppertone
Brazil
Global #7
Fastest growing
market in LATAM
Use investments in brand-building and
channel capabilities to develop key new
categories (sun care, foot care, allergy)
Revitalize Coppertone and Dr. Scholl’s
brands
Russia
Global #4
Retail OTC is
largest healthcare
segment
Focus on CASF brands using current
position to roll-out extended offerings
Achieve #2 position
Execution Plan Focused on Key Brands in
Key Emerging Markets
+38%
+26%
+14%
*Bayer Consumer Care sales, currency-adjusted
50. Consumer Care is Well-Positioned for
Growth – Aspire to Clear OTC Leadership
OTC Market
Attractive
Bayer Has
Strong #2
Position
Plans for
Continued
Future Growth
Trends favor continued growth
OTC market model based on long-term brand building
OTC businesses becoming more valuable over time
Leader in key categories
Multiple strong brands
Track record of outperforming market growth
Globalize established brands & launch innovation pipeline
Focus on emerging markets where most of growth will come
Strategic acquisitions and alliances
Page 48 • Bayer Investor Presentation • Meet Management • June 2014
51. Investor Handout – Meet Management
Bayer HealthCare
June 2014 – New York
52. Leading Positions in Key Healthcare
Markets
• Bayer Investor Presentation • Meet Management • June 2014
Pharma
€11,188m
Leading positions in key therapeutic categories
Consumer Care
€3,904m
Global #2 in OTC-pharmaceuticals
Medical Care
€2,526m
#1 in fluid injection systems, #1 in contrast media,
#3 in blood glucose meters
Animal Health
€1,306m
Global #5, #2 in parasiticides
Sales Split by Segment 2013
25%
59%
7%
21%
13%
HealthCare €18,924m
Page 50
54. FY 2013 –
Top 10 HealthCare Product Performance
• Bayer Investor Presentation • Meet Management • June 2014
MI: Myocardial infarction
Sales in € million; ∆% y-o-y Fx adjusted
+6%
-12%
-1%
+3%
+2%
+10%
-1%
+2%
+211%
1,202
1,038
916
771
949
719
853
722
603
487
Hemophilia A
Multiple Sclerosis
Anticoagulation
Contraception
Cancer
Blood Glucose Meter
Contraception
Analgetic & sec.
MI Prevention
Parasiticide
-13%
Hypertension
Page 52
55. FY 2013 – Strong Business Momentum in
All Regions, Especially Emerging Markets
• Bayer Investor Presentation • Meet Management • June 2014
Emerging Economies
25%
FY 2013 HealthCare Sales
Latin
America
Eastern
Europe
Africa &
Middle East
~2,190
+7%
~1,980
+10%
~1,140
~880
+4%
24%
USA
+5%
30%
33%
13%
Sales in € million; ∆% y-o-y Fx adjusted
Emerging
Economies¹
+8%
Emerging
Asia³
Western
Europe +6%
Others²
+12%
HealthCare €18,924m; +2% (+7%)
Page 53
+10%
1: Emerging economies include: Latin America, Asia w/o Japan, Australia, New Zealand, Africa and Middle East incl. Turkey, Eastern Europe
2: Others = Japan, Australia, New Zealand, Canada; 3: Emerging Asia = Asia w/o Japan, Australia, New Zealand
58. Q1 2014 –
Top 10 HealthCare Product Performance
• Bayer Investor Presentation • Meet Management • June 2014
MI: Myocardial infarction
Sales in € million; ∆% y-o-y Fx adjusted
+133%
-6%
+14%
+12%
+239%
-12%
-1%
-22%
342
270
183
178
190
146
181
157
140
Hemophilia A
Multiple Sclerosis
Anticoagulation
Contraception
Cancer
Ophthalmology
Contraception
Analgetic & sec.
MI Prevention
-3%
Hypertension
Page 56
Blood Glucose Meter
217 +6%
59. • Bayer Investor Presentation • Meet Management • June 2014Page 57
2013 Sales CAGR 2016e
Pharma: Maximize Value of
Launch Products
60. 2011 2012 2013 2014
Page 58
Pharma – Incremental Investments For
A New Performance Level
* new indications and new countries; products include Xarelto, Eylea,
Stivarga, Xofigo, Adempas• Bayer Investor Presentation • Meet Management • June 2014
Launch product sales in € bn
Launch product* sales target of ~€2.8bn
in 2014 (old aspiration 2015: >€2.5bn)
Launch phase to continue with >100
new launch events*
Continuous R&D investments in life-
cycle management
R&D investments in new drug
candidates
Increased marketing and sales
investments in emerging markets
Incremental marketing and R&D
investments of €0.5bn planned in 2014
<0.1
0.4
1.5
~2.8
Stivarga
Xarelto
Eylea
Xofigo
Recently launchd
Pharma products*
61. Pharma – Additional Investments To
Execute >100 Launch Events in 2014
• Bayer Investor Presentation • Meet Management • June 2014Page 59
1: regulatory process ongloing, launch preparations assuming approval
DTC: Differentiated thyroid cancer; mCRC: Metastatic colorectal cancer ;
mGIST: Metastatic gastrointestinal cancer; ACS: Acute coronary syndrome
~ 30 launches planned in secondary prevention of ACS
Market introduction planned in >20 countries
> 30 launches planned in mGIST1 in EU and other markets; continue
roll-out in mCRC (examples include Spain, Italy, Turkey)
~ 15 launches planned, including wetAMD and additional indications
(CRVO, mCNV1, DME1)
Launches1 planned in > 20 countries
> 30 launches planned in DTC1 in EU and other markets
Major Examples
> 30 launches planned
62. • Bayer Investor Presentation • Meet Management • June 2014
Peak Sales Potential of Launch
Products Raised in February 2014
Peak Sales Potential*
* from 5 recently launched products: Xarelto, Eylea, Stivarga, Xofigo, Adempas
Page 60
63. Page 61
Pharma – Peak Sales Potential of Launch
Products Raised in February to ≥ € 7.5bn*
*assuming approvals and launches as planned
Continued successful launch exe-
cution and life cycle management
Continued successful launch exe-
cution and life cycle management
Unchanged
Unchanged
Unchanged
~€3.5bn
≥€1.5bn
≥€1bn
≥€1bn
≥€0.5bn
>€2bn
≥€1bn
Old Current
• Bayer Investor Presentation • Meet Management • June 2014
64. Xarelto – Broadest Profile of Any Novel Oral
Anticoagulant
• Bayer Investor Presentation • Meet Management • June 2014
Peak sales potential ~ €3.5bn
Oral Factor Xa inhibitor
Once-daily dosing advantage*
First launches in EU for secondary
prevention of ACS underway
Two-dimensional approach in life-cycle
management:
Expansion into additional
thromboembolic disease areas
Strengthening the clinical profile in
approved indications and special
patient populations
*exception 15mg BID dosing for treatment of acute DVT/PE or 2.5mg
BID for ACS sec. prevention; ACS: Acute coronary syndromePage 62
65. • Bayer Investor Presentation • Meet Management • June 2014
Xarelto – Performance Exceeding
Expectations
Page 63
World-class launch, achieved
leading position in the novel
anticoagulants segment in key
markets
Uptake significantly exceeding
expectations
Sales target 2014: € 1.3-1.5bn131
155
219
259
316
342
Q4'12 Q1'13 Q2'13 Q3'13 Q4'13 Q1'14
Xarelto sales in million €
66. Expanding and Strengthening the Profile
of Xarelto
• Bayer Investor Presentation • Meet Management • June 2014Page 64
Significant medical need in thromboembolic disease areas
Heterogeneous patient populations in existing indications deserve further
characterisation
Two-dimensional approach in life-cycle management
Expansion into addional
thromboembolic disease areas
Strenghtening the clinical profile in
approved indications
Peripherial arterial disease / coronary
arterial disease
Chronic heart failure with coronary
arterial disease
Medically ill patients
Patients with percutaneus coronary
intervention
Patients who undergo cardioversion
Patients undergoing ablation
Evaluate 10mg /20mg dose vs. ASA in
secondary prevention of VTE
ASA: Acetylsalicylic acid, VTE: Venous thromboembolism
67. Eylea – Developed for the Treatment of
Multiple Back-of-the-Eye-Diseases
• Bayer Investor Presentation • Meet Management • June 2014
Peak sales potential ≥ €1.5bn
Eylea is an anti-angiogenic therapy,
formulated for injection into the eye
Strong adoption by retina community in
wAMD based on convenient bimonthly
dosing1 regimen
Comprehensive range of indications to
address major eye diseases2:
Launched in wAMD and CRVO; roll-out
ongoing
Filed for DME (EU: 11/13; J: 02/14)
Filed for mCNV in Japan (11/13)
Filing planned for BRVO (in J, other
regions under evaluation)
1: after an initial phase of 3 consecutive monthly injections; 2: Bayer has marketing rights ex-US; wAMD: Wet age-related macular degeneration; CRVO:
Central retinal vein occlusion; BRVO: Branched retinal vein occlusion; mCNV: Myopic choroidal neovascularization; DME: Diabetic macular edema
Page 65
68. • Bayer Investor Presentation • Meet Management • June 2014
Eylea – Excellent Launch Trajectory
Page 66
Excellent launch execution ahead of
expectations
Market shares* > 45 % in Japan and
Australia
Roll-out in Europe underway
Strong uptake in early launch markets
Germany and Switzerland
Encouraging launch in France and UK
Positive NICE guidance for CRVO
indication in UK obtained in 02/14
Progress with launch preparations for
i) additional countries and ii) additional
back-of-the-eye diseases**
*Market share as of December 2013 (Source IMS)
** pending regulatory approval
14
49
73
85
126
157
Q4'12 Q1'13 Q2'13 Q3'13 Q4'13 Q1'14
Eylea sales in million €
69. Stivarga – Developed as a Treatment for
Cancers of the Digestive Tract
• Bayer Investor Presentation • Meet Management • June 2014
Oral cancer drug, potently blocking multiple
protein kinases
Launched for treatment of mCRC and
mGIST in the US & Japan
Launched for treatment of mCRC (8/13)
and filed for mGIST (9/13) in Europe
Encouraging initial uptake
Expanding to new indications
Phase III in 2nd line liver cancer
ongoing
Phase III in CRC (adjuvant therapy
after resection of liver metastases)
ongoing
mCRC: Metastatic colorectal cancer
GIST: Gastrointestinal stromal tumors
Peak sales potential ≥ €1bn
Page 67
70. Entering Additional Cancers of the
Gastro-Intestinal Tract with Stivarga
• Bayer Investor Presentation • Meet Management • June 2014Page 68
Positive clinical data in metastatic colorectal cancer and 2nd-line
hepatocellular carcinoma
Mode of action suggesting activity in a broad range of tumor types
Life-cycle management targets:
Phase III in 2nd-line hepatocellular
carcinoma
Phase III in colorectal cancer after
resection of liver metastases
Signal generating early clinical studies
in various cancer types including
gastric cancer
HCC: Hepatocellular carcinoma
CRC: Colorectal cancer
Expand in HCC and CRC Expand to additional tumor types
71. • Bayer Investor Presentation • Meet Management • June 2014
Xofigo – A New Treatment for CRPC
Patients with Bone Metastases
First in class alpha-pharmaceutical
Treatment of CRPC with symptomatic bone
metastases and no known visceral
metastatic disease
Launched in the US (06/13)
Approved in Europe (11/13) – launch
underway
High awareness among oncologists and
urologists
Life-cycle program initiated (including
combination studies in earlier settings of
prostate cancer)
CRPC: Castration-resistant prostate cancer
Peak sales potential ≥ €1bn
Page 69
72. Addressing Multiple Life-Cycle Opportunities
for Xofigo (Radium-223 dichloride)
• Bayer Investor Presentation • Meet Management • June 2014Page 70
Life-Cycle
Opportunities
Repeat dosing in CRPC
Higher dose in CRPC
Earlier disease stages
of CRPC
Combination study in CRPC
Expansion into additional
cancer types
Addressed Through
Phase II trial assessing the short
and long-term safety of re-
treatment
Phase II trial with dose higher
than the approved 50 kBq/kg
Phase I and/or II studies in breast
cancer, osteosarcoma and
potentially in additional cancer
types
Phase III combination trial with
abiraterone / phase II combination
with abiraterone or enzalutamide
CRPC: Castration resistant prostate cancer
Status
initiated
initiated
initiated
planned
73. Adempas – First-in-Class sGC Stimulator for
Treatment of PAH and CTEPH
• Bayer Investor Presentation • Meet Management • June 2014
Oral soluble guanylate cyclase (sGC)
stimulator approved for treatment of PAH
and CTEPH
First and only drug receiving marketing
authorization for the treatment of CTEPH
Launched in the US for treatment of PAH
and CTEPH (10/13)
Launched in J for treatment of CTEPH
(04/14) – filed for PAH (04/14)
Launched in first EU countries for CTEPH
and PAH (04/14)
Collaboration with Merck & Co. announced
in May 2014 - 50/50 cost/profit split, joint
development and commercialization
strategy
*for indications PAH and CTEPH; CTEPH; : Chronic
thromboembolic pulmonary hypertension; PAH: Pulmonary arterial
hypertension
Peak sales potential ≥ €0.5bn*
Page 71
74. Adempas – Life Cycle Management Beyond
PAH and CTEPH
• Bayer Investor Presentation • Meet Management • June 2014
PAH: Pulmonary arterial hypertension; CTEPH: Chronic thromboembolic
pulmonary hypertension; PH-ILD: Pulmonary hypertension due to
interstitial lung disease
Page 72
Positive phase II data in PH-ILD prompt initiation of phase IIb in PH-IIP (a specific sub-
segment of PH-ILD)
Majority of PH-IIP patients suffer from pulmonary hypertension due to idiopathic
pulmonary fibrosis
No approved treatment option
Chronic systemic autoimmune disease characterized by fibrosis
No approved treatment
Strong preclinical antifibrotic data
Pulmonary hypertension with idiopathic interstitial pneumonia (PH-IIP)
Diffuse systemic sclerosis (SSc)
75. Page 73
Accelerating the Development
of 5 early/mid-stage Pipeline
Assets
• Bayer Investor Presentation • Meet Management • June 2014
R&D
76. Five New Molecular Entities Selected For
Accelerated Development
• Bayer Investor Presentation • Meet Management • June 2014Page 74
Project Mechanism Indication Status
Copanlisib
(BAY 80-6946)
PI3-Kinase
Inhibitor
Cancer
Phase II in NHL
ongoing
Finerenone
(BAY 94-8862)
MR Antagonist
Chronic heart failure (CHF)
Diabetic nephropathy (DN)
Phase IIb in CHF and
phase II in DN
ongoing
Molidustat
(BAY 85-3934)
HIF-PH Inhibitor Anemia Phase IIb ongoing
Vericiguat
(sGC-Stimulator BAY 1021189)
sGC Stimulator
Worsening chronic heart
failure
Phase IIb ongoing;
collaboration with
Merck & Co. Inc.
Vilaprisan (sPRM)
(BAY 1002670)
Progesterone
Receptor
Antagonist
Symptomatic uterine
fibroids
Phase IIb ongoing
MR: Mineralocorticoid receptor; NHL: Non-Hodkin´s lymphoma
HIF-PH: HIF prolyl hydroxylase; sGC: Soluble guanylate cyclase;
sPRM: Selective progesterone receptor modulator
77. Positive Proof-of-Concept Increases
Confidence in NME-quality
• Bayer Investor Presentation • Meet Management • June 2014Page 75
NME: New molecular entity
CHF: Chronic heart failure
EPO: Erythropoietin
Copanlisib
Finerenone
Molidustat
Vericiguat
(sGC-Stimulator)
Vilaprisan
(sPRM)
100% of patients (6/6) with follicular lymphoma achieved
a partial response as best response in phase I
Phase II results in CHF patients suggest improved safety
with at least similar efficacy compared to spironolactone
Improvement in important cardiological parameters
observed in phase I
Significant increase in levels of endogeneous EPO and
reticulocytes demonstrated in phase I
Phase IIa data demonstrated reversible induction of
amenorrhea
78. • Bayer Investor Presentation • Meet Management • June 2014Page 76
Copanlisib (BAY 80-6946) –
A PI3K-Inhibitor in Phase II in Cancer
● In most tumor cells, the PI3K-signaling
cascade is activated and provides
important tumor growth and survival
signals
● Copanlisib is a pan class I PI3K-inhibitor
with dominant activity
● Copanlisib has shown a broad anti-
tumor spectrum in preclinical tumor
models
● Phase II in Non-Hodgkin’s lymphoma is
ongoing; completion expected 1H 2015
Phosphatidylinositol-3 kinases (PI3K)
play a central role in cellular signal
transduction processes
Copanlisib
79. • Bayer Investor Presentation • Meet Management • June 2014Page 77
Copanlisib Has Shown Substantial Activity in
Follicular Lymphoma
*Data from Patnaik A et al.; ASH 2012; 18FDG-PET: 18fluorodeoxyglucose -
positron emission tomography
18FDG-PET scans of a follicular lymphoma
patient with partial response
● Phase I trial successfully completed
● 100% of patients (6/6) with
follicular lymphoma (FL)
responded to therapy achieving a
partial response as best response*
● Maximum response duration > 840
days
● Encouraging signals in diffuse
large B cell lymphoma patients
● 18FDG-PET data suggest that
Copanlisib has rapid antitumor activity
52-year-old female with FL, grade 1-2, diagnosed stage IVa
80. • Bayer Investor Presentation • Meet Management • June 2014Page 78
Selective Progesterone Receptor Modulation
for Treatment of Uterine Fibroids
● Uterine fibroids are the most common
benign tumors in women of reproductive
age: 5-10% of premenopausal population
suffers from symptomatic fibroids
● Symptoms may include heavy menstrual
bleeding and tumor size related symptoms
● Current therapies include surgical
procedures or short-term use of GnRH
analogs for estrogen depletion
● Growth of fibroids strongly depends on
progesterone and estrogen
● Progesterone receptor modulation may
offer long-term treatment of uterine fibroids
without estrogen depletion side effects of
GnRH analogs
GnRH: Gonadotropin-releasing hormone
sPRM: Selective progesterone receptor modulator
PR
Transcription
Activation
Endometrial
Modulation &
Fibroid Growth
sPRM
Transcription
Endometrial
Modulation &
Fibroid Growth
PR
81. • Bayer Investor Presentation • Meet Management • June 2014Page 79
Vilaprisan (sPRM; BAY 1002670) – For the
Treatment of Symptomatic Uterine Fibroids
● Vilaprisan is a novel oral, highly potent
and selective progesterone receptor
modulator
● Exhibits marked efficacy in an
innovative humanized fibroid disease
model1
● Phase IIa data (N=67) showed proof of
concept including:
● Reduction of bleeding: induced
amenorrhea (non-bleeding) in >60%
of women treated with dosages
>1mg/day
● Reversal of amenorrhea after
treatment cessation
● No prohibitive safety findings
1 Wagenfeld et al. Hum Reprod. 2013 Aug;28(8):2253-64
Phase IIa data BAY Vilaprisan
Dose effect curve for amenorrhea rate
0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5
0102030405060708090100
Point estimate (median)
90% Credible interval
Observed rate
Efficacy threshold
Dose (mg)
Amenorrhearate(%)
82. • Bayer Investor Presentation • Meet Management • June 2014Page 80
Renal Anemia is an Important Area of Unmet
Medical Need
● Diseased kidneys do not produce
sufficient levels of erythropoietin (EPO)
in response to hypoxia, leading to
anemia
● CKD/ESRD is the leading cause of
anemia in industrialized countries
● Substitution with parenteral EPO is
standard of care – however, un-
physiologically high EPO doses
correlate with significant side effects
● There is a need for novel therapies that
lack the side effects of high doses of
EPO-substitution
CKD: Chronic kidney disease
ESRD: End-stage renal disease
Anemia
Low oxygen
level (Hypoxia)
Normal kidney
function
Impaired kidney
function
EPO
Red blood cell
formation
EPO
Normal red blood
cell count
Insufficient
formation of
red blood cells
83. • Bayer Investor Presentation • Meet Management • June 2014Page 81
Molidustat – An Oral HIF-PH Inhibitor for
Treatment of Renal Anemia
Increased red blood
cell production
Inhibition of HIF-PH increases the
stability of HIF resulting in production of
endogeneous EPO - potential novel
therapeutic approach for the treatment
of renal anemia
Under normal oxygen conditions, HIF
gets hydroxylated by HIF-PH and then
degraded
Under hypoxia conditions, HIF is
activated and induces the synthesis of
erythropoietin (EPO) in the kidneys
which stimulates red blood cell
formation
Nucleus
HIFHIF
Low oxygen levels
HIF
Hydroxylation
HIF
Normal oxygen levels
HIF-PH
O2
hHIFhHIF
Degradation
Degraded HIF
HIFHIF
Inhibition of HIF-PH in renal anemia
HIF-PH
O2
EPO ↑
Nucleus
EPO ↑
Nucleus
Increased red blood
cell production
HIF: Hypoxia-inducible factor
HIF-PH: HIF prolyl hydroxylase (enzyme)
hHIF: hydroxylated HIF
84. • Bayer Investor Presentation • Meet Management • June 2014Page 82
Molidustat (BAY 85-3934) –
Proof of Concept Demonstrated
EPO: Erythropoietin
HIF-PH: HIF prolyl hydroxylase
● Molidustat is a novel oral inhibitor of the
enzyme HIF-PH
● In development for the treatment of
anemia associated with chronic kidney
disease
● Phase I in healthy subjects showed:
● Significant increase of EPO levels
after ≥ 12.5 mg
● Significant increase of reticulocytes
for doses ≥ 37.5 mg
● No prohibitive safety findings
Maximal EPO concentration after single
dose administration of Molidustat (Phase I)
0
10
20
30
40
50
Placebo 5 mg 12,5 mg 25 mg 37,5 mg 50 mg
EPO[U/L]
Dose
85. • Bayer Investor Presentation • Meet Management • June 2014Page 83
MR-Inhibition is a Proven Principle in the
Treatment of Heart Diseases
MR: Mineralocorticoid receptor
HF: Heart failure
aldosterone / cortisol
Overactivated
MR
causing e.g.
Na+ and water retention
K+ loss
Hypertensive effects
Vascular
inflammation/injury
Myocardial/renal fibrosis
Proteinuria
MR antagonist
KidneyHeart
MR has multiple functions:
Regulation of salt, fluid homoestasis
and blood pressure
Mediator of oxidative stress,
subsequent inflammation, fibrosis and
cardiorenal disease
Steroidal MR antagonists spironolactone
and eplerenone have been shown to be
effective in reducing cardiovascular
mortality in patients with HF but are
underutilized due to the risk of
hyperkalaemia, renal dysfunction and
anti-androgenic / progestogenic side
effects
Steroidal MR antagonists are not
approved for kidney diseases eg. diabetic
nephropathy
86. • Bayer Investor Presentation • Meet Management • June 2014Page 84
Finerenone – A Novel Non-Steroidal and
Selective MR-Antagonist
CHF: Chronic heart failure; CKD: Chronic kidney disease
BNP: Brain natriuretic peptide;
B. Pitt et al., Eur. Heart J. 2013; doi:10.1093/eurheartj/eht187
Mean increases in serum potassium concentration
Finerenone10mg o.d.: 0.21 mmol/l
Spironolactone: 0.45 mmol/l
P <0.001
Mean change in estimated glomerular filtration rate
Finerenone10mg o.d.: -2.69 ml/min/1.73m²
Spironolactone: -6.70 ml/min/1.73m²
P <0.05
Median change from baseline in NT-proBNP
Finerenone 10mg o.d.: -193 pg/mL
Spironolactone: -170 pg/mL
(descriptive analysis)
Decreased BNP/NT-proBNP – a key
parameter for cardiac stress
Indicates lower incidence of
hyperkalaemia
Indicates lower incidence of worsening
of renal function
Phase II results suggest improved safety with at least similar efficacy on key
cardiac and renal parameters compared to spironolactone
Data at Day 29 +/- 2 in part B of the study with 392 pts in total;Spironolactone was given at an initial dose of 25mg o.d. and uptitrated to 50mg o.d.
on day 15±1 if sodium potassium concentration remained ≤4.8mmol/L; * eGFR 30-60 ml/min/1.73m²
Key phase II findings in patients with CHF and moderate* (part B) CKD :
87. • Bayer Investor Presentation • Meet Management • June 2014Page 85
sGC Modulation Has Significant Potential
Cardiovascular diseases to be the
#2 therapeutic area by 2019**
Significant areas of unmet medical
need including heart failure,
forms of pulmonary hypertension,
resistant hypertension, etc.
Recently discovered mechanism
of sGC modulation holds promise
to address several areas of unmet
need
Unmet Medical Need in
Cardiovascular Diseases
sGC Modulation
*
sGC: Soluble guanylate cyclase; *cyclic guanosine monophosphate
**DecisionResources 2014
88. Strategic Pharma sGC Collaboration with
Merck & Co. Inc.
Maximize potential of all pipeline assets
Leverage R&D expertise in cardiovascular
Improve funding capabilities – thereby maximizing commercial
potential of pipeline assets
Optimize combined marketing & sales power
Collaboration between Merck and Bayer on sGC modulation to
Page 86
Joint development and commercialization strategy with global
50-50 cost and profit sharing
Merck to pay Bayer up to $2.1bn, comprising $1.0bn up-front
and up to $1.1bn in contingent milestone payments
• Bayer Investor Presentation • Meet Management • June 2014
89. Maximizing the Potential of sGC Modulation
Bayer has marketing rights in Americas;
Merck in all other territories
Co-promotion option for both parties in
territories of other party
Enables Bayer to build its commercial
presence in US specialty pharma while
maximizing value of Adempas
*scope defined by sGC mechanism
Adempas (Riociguat) Vericiguat (BAY 1021189)
Merck has marketing rights in Americas;
Bayer in all other territories
Co-promotion option for both parties in
territories of other party
Maximizes value of Vericiguat by
leveraging Merck’s US strength
Early/Future Pipeline Assets*
Option to include other sGC pipeline assets (of both parties) that successfully complete
Phase 1 in the next 5 years
Global 50/50 cost/profit split; joint development and commercialization strategy
Page 87 • Bayer Investor Presentation • Meet Management • June 2014
90. • Bayer Investor Presentation • Meet Management • June 2014Page 88
sGC Stimulation to Address Unmet Medical
Need in Patients with Heart Failure
● Worsening chronic heart failure is an
established indication with high medical
need
● Limitations of standard of care include
tolerance, oxidative stress, endothelial
dysfunction and venoselectivity
● sGC stimulation can improve
hemodynamics via restoration of
cardiac and vascular cGMP signaling
● sGC stimulation may provide a new
principle to reduce event rates in
patients with worsening chronic heart
failure
Clinicalstatus
Patients who require hospitalization due to HF
(worsening HF) have a poor prognosis with high
rates of re-hospitalization and death
sGC: Soluble guanylate cyclase
HF: Heart failure
91. • Bayer Investor Presentation • Meet Management • June 2014Page 89
Vericiguat (sGC Stimulator; BAY 1021189) –
Improvement of Cardiovascular Function
sGC: Soluble guanylate cyclase
HF: Heart failure
Phase I of Vericiguat show improved cardiac
output (n = 36)
Fi gur e: Means and st andard devi at i ons f or i mpedance cardi ography over t i me f or Cardi ac Out put (L/ mi n) over t i me (val i d f or PD)
Day 1
0H 00M 1H 00M 2H 00M 3H 00M 4H 00M
3. 0
3. 5
4. 0
4. 5
5. 0
5. 5
6. 0
6. 5
7. 0
Placebo
5 mg
7.5 mg
10 mg
0 1 2 3 4
Time (h)
33.544.55.05.56.06.57.0
Vericiguat is a novel sGC stimulator
suitable for once-a-day dosing
Phase I successfully completed –
improvement observed in important
cardiological parameters, including:
Cardiac output / index (“volume of
blood pumped by the heart”)
Systemic vascular resistance
Stroke volume
No untoward safety findings in phase I
Collaboration with Merck & Co (50/50
cost/profit split), joint development and
commercialization strategy
Cardiacoutput(L/min)
92. The New sGC Franchise is Strong
in the Industry
Phase I Phase III Submitted LaunchedPhase IIIndicationProject
PAH/CTEPH
PH-IIP
dSSc
CF
wCHF
PH
PH-HF
Adempas
Vericiguat
MK 8892*
rHT
Research*
in preparation
in preparation
in preparation
Research/
Preclin.
• Bayer Investor Presentation • Meet Management • June 2014Page 90
PH: Pulmonary hypertension; PAH:Pulmonary arterial hypertension;
CTEPH: Chronic thrombmoembolic PH; PH-IIP: PH assoc. with interstitial idiopathic
pneumonia; dSSc: Diffuse systemic sclerosis; CF: Cystic fibrosis; wCHF: Worsening
chronic heart failure; rHT: Resistant hypertension; HF: Heart failure
*Potential collaboration assets, subject to execution of options in the next 5 years after successful completion of Phase 1
BAY sGCstim
*
BAY sGCact
*
Raynaud’s
93. Major Expected Pharma Pipeline Newsflow
2014/2015
• Bayer Investor Presentation • Meet Management • June 2014
Estimated primary study completion as of May 2014
HCC: Hepatocellular carcinoma; NHL: Non-Hodkin‘s lymphoma;; MR: Mineralocorticoid receptor; HF: Heart failure;
PI3-Kinase: Phosphatidylinositol-3 kinases, sGC :Soluble guanylate cyclase; HIF-PH: HIF prolyl hydroxylase
Page 91
2014
2015
BAY 85-8501 (Elastase Inhibitor) Completion of phase II in bronchiectasis
Copanlisib (PI3-Kinase Inhibitor) Completion of phase II in NHL
Stivarga Completion of phase III in 2nd-line HCC
Finerenone (MRAntagonist) Completion of phase II in diabetic nephropathy
Vericiguat Completion of phase II in worsening chronic HF
Molidustat (HIF-PH Inhibitor) Completion of phase II
Finerenone (MR Antagonist) Completion of phase II in worsening chronic HF
Nexavar Completion of phase III in breast cancer (RESILIENCE)
Vilaprisan (SPRM) Completion of phase II
94. • Bayer Investor Presentation • Meet Management • June 2014
Established Pharma Products
Page 92
95. 2010 2011 2012 2013
Hemophilia Franchise –
Stable Growth
• Bayer Investor Presentation • Meet Management • June 2014
Global # 2 in hemophilia A treatment
Competitive portfolio in hemophilia:
Positive phase III data with site-
directed PEGylated long-acting
Factor VIII (BAY 94-9027)
Product from plasma-free
process (BAY 81-8973) – filing
planned for 2014
Investment of € >500m planned to
establish additional manufacturing
capacities for recombinant FVIII
products in development
Sales in € million; ∆% Fx adj.
299
705
290
785
332
850
US Rest of the world
1,004
1,075
1,182
+6%
Page 93
330
872
1,202
96. Prophylaxis in Hemophilia – Breakthrough in
Prolonging Dosing Intervals
• Bayer Investor Presentation • Meet Management • June 2014Page 94
Prophylaxis can protect hemophilia patients more effective compared to on-
demand treatment in terms of
Reducing frequency and severity of bleeding episodes
Preserving joint health/function and
Maintaining overall long-term health status
However, current standard in prophylaxis involves two to three infusions per
week
A long-time goal in hemophilia prophylaxis has been to reduce the burden
from frequent infusions
PROTECT VIII demonstrated evidence of reliable prophylaxis of bleeding in
hemophilia A with dosing at every 5 and 7 day intervals
97. Expanding the Hemophilia Franchise – Long-
Acting Site-directed PEGylated Factor VIII
• Bayer Investor Presentation • Meet Management • June 2014Page 95
Damoctocog alfa pegol (BAY 94-
9027) is a B-domain–deleted
recombinant factor VIII (BDD-rFVIII)
with site-specific PEGylation
Attachment of PEG extends half-life
without reducing FVIII activity
Positive PROTECT VIII phase III
data
Filing US, EU and other regions
planned for 2H’2015
Site-specific
PEGylation to
extend FVIII
half life
B-domain
deletion
98. Damoctocog alfa pegol (BAY 94-9027) –
Design of the PROTECT VIII Phase III Study
• Bayer Investor Presentation • Meet Management • June 2014Page 96
PROTECT VIII is a pivotal study assessing safety and efficacy of the site-
directed PEGylated FVIII Damoctocog alfa pegol
Part A: On-demand and prophylactic treatment (completed)
Part B: Major surgery (ongoing)
6
Randomization
0 10 14 20 28weeks
2x/week 25 IU/kg (n 120)
2 or more breakthrough bleeds:
No or 1 breakthrough bleeds:
36
Screening
Screening
2
On‐demand therapy individual dosage n=20
2x/week 30 to 40 IU/kg n=24*
Every 5 days 45‐60 IU/kg n=43
Every 7 days 60 IU/kg n=43
* 13 assigned due to bleeding; 11 default/randomization arms full
38
99. Damoctocog alfa pegol Phase III Results -
Reduction of Infusion Frequency in Prophylaxis
• Bayer Investor Presentation • Meet Management • June 2014Page 97
Met primary objective of protection from bleeds with fewer infusions
Extending infusion intervals up to 7 days resulted in protection from bleeds
No inhibitors against FVIII developed during treatment period
Study Arm
Patients (n)
remaining on
treatment
Patients with no
bleeding
Median ABR
Prophylaxis: infusion
2x/week
n.a. n.a.
17.4 (reduction to 4.1 after
dose increase)
Prophylaxis: infusion
every 5 days
43/43 44% 1.9
Prophylaxis: infusion
every 7 days
32/43
37%
(incl. non-completers)
3.9 *
(incl. non-completers)
On-demand treatment n.a. n.a. 23.0
ABR: Annualized bleeding rate
*Median ABR for the 32 (74%) completers was 0.96
100. The Leader in Women’s HealthCare
• Bayer Investor Presentation • Meet Management • June 2014
Yaz family
Sales ∆% y-o-y, () FX adj.
Women’s Healthcare 2013
€3,034m
-7% (-1%)*
+6 (+10)Mirena
-23 (-16)Diane
-18 (-13)
+7 (+12)Qlaira
Other products +1 (+7)
-13 (-8)Microgynon
-2 (0)Valette
-13 (-8)Meliane
-7 (-1)Angeliq
Page 98
* Fx & portf. adjusted growth -4% due to Essure with €74m sales in 2013
101. • Bayer Investor Presentation • Meet Management • June 2014
Strengthening Women‘s Health Business –
Acquisition of Conceptus, Inc.
Bayer successfully completed the public tender offer to acquire all shares in
Conceptus for a purchase price of €780m
US-based company developing the Essure® procedure, the leading non-
surgical permanent birth control method proven by >700,000 procedures
Significant synergies expected from leveraging existing business power
Essure ®
Permanent
Long-term
Short-term
No children Active family planning Family planning finalized
IUD (Mirena)
IUD (Skyla)
Oral contraceptives (e.g. YAZ)
Page 99
102. Mirena – The Leading Hormonal Long-
Acting Contraceptive
• Bayer Investor Presentation • Meet Management • June 2014
Intrauterine device, containing
levonorgestrel, for reversible long-
term contraception
Life-cycle opportunities:
Small low-dose long-acting (up to 3
years) device:
Jaydess; launched in EU
Skyla; launched in the US
Phase III for a long-acting (up to 5
years), low-dose, small
contraception device underway
Sales in € million; ∆% Fx adj.
2010 2011 2012 2013
285
254
313
268
385
292
US Rest of the world
539
581
677
+10%
Page 100
415
304
719
103. Betaseron – Long-term Experience in
Multiple Sclerosis Treatment
• Bayer Investor Presentation • Meet Management • June 2014
First interferon launched in multiple
sclerosis, introduced in 1993
Wealth of clinical experience
Demonstrating excellent efficacy and
tolerability
21-year long-term follow-up study
demonstrated significant survival
advantage with Betaseron treatment
Launch of BETACONNECT (new
electronic auto-injector) in Europe
underway
Sales in € million; ∆% Fx adj.
2010 2011 2012 2013
473
733
447
670
578
638
US Rest of the world
1,206
1,117
1,216 -12%
Page 101
499
539
1,038
104. Nexavar –
Our Cornerstone in Oncology
• Bayer Investor Presentation • Meet Management • June 2014
Approved for kidney cancer (RCC),
liver cancer (HCC) and radioactive
iodine refractory differentiated thyroid
cancer (DTC)
Only approved drug with overall
survival benefit in HCC
Phase III trials in:
Breast cancer
RCC (adjuvant)
Sales in € million; ∆% Fx adj.
2010 2011 2012 2103
174
531
174
551
204
588
US Rest of the world
705 725
792
+3%
Page 102
219
552
771
105. Aspirin –
Sustainable for More Than A Century
• Bayer Investor Presentation • Meet Management • June 2014
One of the world’s most recognized
brands
Available as OTC and Rx Aspirin
Bayer’s #1 product in Emerging
Markets; 8% growth in China in
2013
Sales in € million; ∆% Fx adj.
2010 2011 2012 2013
358
418
404
471
476
494
Rx-Aspirin OTC-Aspirin
776
875
970 -1%
Page 103
452
464
916
106. • Bayer Investor Presentation • Meet Management • June 2014Page 104
Aspire to Become the Leading
OTC Company
107. Evolution of Bayer Consumer Care’s
OTC Business
2008
Acquisition of OTC brand
portfolio from Sagmel
(CEE) and Topsun (China)
1999
Aspirin trademark
centenary-worldwide
sales > €500m
1899
ASPIRIN introduced
as an over-the-counter
(OTC) medicine
1994
Consumer Care business group
created by the acquisition of North
American OTC business of Sterling;
Acquisition of the “Bayer Cross”
Trademark in USA
2005
Acquisition of Roche
Consumer Health
2013
Aspirin trademark sales
of >€900m
Acquisition of
Steigerwald (Germany)
Page 105 • Bayer Investor Presentation • Meet Management • June 2014
2014
Proposed acquisition of Merck’s
Consumer Care business (US)
Transaction agreement signed with
Dihon Pharmaceutical Group (China)
108. • Bayer Investor Presentation • Meet Management • June 2014Page 106
Growth Strategy
Maximize brand potential
Global expansion of key brands
Exploit our innovation pipeline
Grow in emerging markets
Increase commercial power
Bolt-on acquisitions to strengthen
portfolio & regional set-up
3.4
3.5
3.9 3.9
2010 2011 2012 2013
+5%
+7%
+6%
Consumer Care sales in € billion; ∆% Fx & portfolio adj.
Bayer Consumer Care – Outperforming
Markets in Past 7 Out of 8 Years
109. Merck’s Consumer Care Business Fits
Perfectly With Bayer Consumer Care
• Bayer Investor Presentation • Meet Management • June 2014
Complementary
Portfolio
Building on core
competencies
Creation of a global leader in OTC
Gaining scale in key categories CASF1, dermatology,
and gastrointestinal
Optimizing footprint in North America
Strong track record of growing OTC brands
Strong geographical presence to broaden Merck’s
portfolio globally
Utilizing integration skills from past transactions
Page 107
Acquisition criteria
fulfilled
Creating leadership positions in important consumer
care categories and geographies
Increasing consumer care margin2 by ~1pp from year 1
Immediate core EPS accretion from year 13
1 cold, allergy, sinus, flu; 2 EBITDA pre-special items;
3 transaction incl. sGC collaboration
110. Page 108 • Bayer Investor Presentation • Meet Management • June 2014
Combined Portfolio Significantly Strengthens
Global Positions
Gastrointestinal
Analgesics3
CASF2
Nutritionals
Dermatology1
Total
Others4
3,904 1,635 5,539
1,110 386
372 803
126 513
439 141
1,023
834
1 including sun care; 2 Cold, Allergy, Sinus, Flu; 3 including Cardio; 4 Foot Health, Women’s Health, Other
1,496
1,023
1,175
834
580
431
#1
#2
#3
#1
#2
Global position*2013 Sales in €m (pro-forma portfolio)
Note: Merck sales converted at average USD rate of 1.33 (FY 2013)
305
*After allowing for the Novartis/Glaxo deal; excluding Dihon acquisition in China; excluding Rx
MerckBayer
111. Page 109 • Bayer Investor Presentation • Meet Management • June 2014
Combined Portfolio Significantly Strengthens
Geographic Footprint
Note: Merck sales converted at average USD rate of 1.33 (FY 2013)
*After allowing for the Novartis/Glaxo deal; excluding Dihon acquisition in China; excluding Rx
Latin America
Europe
North America
Total
Asia/Pacific
3,904 1,635 5,539
1,117 1,105
1,621 170
389
513
141
777
2,222
1,791
946
580
#1
#1
#5
#2
Global position*2013 Sales in €m (pro-forma portfolio)
191
169
MerckBayer
112. FY 2013 sales in € million (∆% yoy Fx-adj.)
321
310
232
214**
207
176
158
257
*Total Aspirin includes Aspirin Complex and Aspirin Cardio (Rx)
**Total Alka-Seltzer includes Alka-Seltzer and Alka-Seltzer Plus
916*
= Rx Sales
Page 110 • Bayer Investor Presentation • Meet Management • June 2014
Combined Top 10 Portfolio –
Individual Brands with Annual Sales >€100m
576
Note: Merck sales converted at average USD rate of 1.33 (FY 2013); based on pro-forma FY 2013 net sales
113. • Bayer Investor Presentation • Meet Management • June 2014Page 111
Top Priorities To Be Executed Immediately
After Closing of Transaction…
Ensure fast integration into operations
Safeguard product supply
Realize synergy potential
Prioritize brand strategies within combined portfolio
Realize Merck brand penetration opportunities ex-US
Define and execute individual brand strategies
Develop US scale advantage
Strive for leadership with trade customers
Provide a broader product portfolio
Critical mass
in US
Brand Roll-
Out ex-US
Smooth
integration
114. • Bayer Investor Presentation • Meet Management • June 2014Page 112
Clear Strategy For a Smooth Integration
2014 Q2 2014 Q42014 Q3 2015 (End State)
Smooth integration expected due to experienced management team
• Ensure effective integration into Consumer Care
• Safeguard on-going product supply
• Prioritize and execute identified brand development / expansion strategies
• Ensure sufficient future capacity for growth
• Capitalize on Merck’s innovation capabilities
• Achieve scale and revenue synergies
• Capture consolidation and efficiency synergies by 2017
Deal signing Deal closing Consolidation / Integration
115. • Bayer Investor Presentation • Meet Management • June 2014Page 113
Enhanced Scale and Broader Category
Scope Improve Product Offerings
US Retail Sales CASF Benefits from Enhanced Scale
Co-promoting complementary
brands
New item assortment and shelving
opportunities
Improved merchandising efficiencies
Bigger and more impactful trade
events
Foster strategic partnerships with
retailers
FY 2013 retail sales in CASF in $ million*
$-
$200
$400
$600
$800
$1,000
$1,200
RB Bayer &
Merck
J&J Merck &
Co.
P&G Pfizer Chattem Bayer GSK
*Source: IRI; Latest 52WK; December 2013
Make Bayer Consumer Care Top Strategic Partner for US Retailers
116. Maximizing Brand Potential Through
Global Expansion
Brand Sales by Major Region 2013 Expansion Plans
• Bayer Investor Presentation • Meet Management • June 2014Page 114
Analgesic
~80% in North America
~95% in North America
Wound-healing
~75% in Europe
Anti-fungal
~75% in Europe & LatAm
Vitamins & minerals
~50% in Europe
~80% in North America
CASF
Sun Care
117. • Bayer Investor Presentation • Meet Management • June 2014Page 115
Russia
Country OTC Market
Sales Growth
2013*
Execution Plans
China
Global #2
Growing 2x the
global rate
Use investments in footprint, brand-building
and sales capabilities to extend Claritin
leadership
Build sun care category with Coppertone
Brazil
Global #7
Fastest growing
market in LATAM
Use investments in brand-building and
channel capabilities to develop key new
categories (sun care, foot care, allergy)
Revitalize Coppertone and Dr. Scholl’s
brands
Russia
Global #4
Retail OTC is
largest healthcare
segment
Focus on CASF brands using current
position to roll-out extended offerings
Achieve #2 position
Execution Plan Focused on Key Brands in
Key Emerging Markets
+38%
+26%
+14%
*Bayer Consumer Care sales, currency-adjusted
118. Consumer Care is Well-Positioned for
Growth – Aspire to Clear OTC Leadership
OTC Market
Attractive
Bayer Has
Strong #2
Position
Plans for
Continued
Future Growth
Trends favor continued growth
OTC market model based on long-term brand building
OTC businesses becoming more valuable over time
Leader in key categories
Multiple strong brands
Track record of outperforming market growth
Globalize established brands & launch innovation pipeline
Focus on emerging markets where most of growth will come
Strategic acquisitions and alliances
Page 116 • Bayer Investor Presentation • Meet Management • June 2014
119. • Bayer Investor Presentation • Meet Management • June 2014Page 117
Animal Health – Operating in an
Attractive Market Environment
120. • Bayer Investor Presentation • Meet Management • June 2014Page 118
Demonstrating a Solid, Long-Term Sales
Growth Trajectory
Sales in € million; ∆% Fx & portfolio adj.
Overall global #5 and global #2 in
parasiticides
Ranked #3 in CAP (~60% of sales)
Sector driven by:
Emotional relationships to pets
Infectious and chronic diseases
Ranked #7 in FAP (~40% of sales)
Sector driven by:
Increasing customer/consumer
awareness
Food safety & disease transmission
Globalization in farm exports
Highlights
977
1,120
1,186
1,303 1,306
2009 2010 2011 2012 2013
+4%
121. • Bayer Investor Presentation • Meet Management • June 2014Page 119
Aspiring Further Sustainable Growth
6%
AH Market 2013 by Player
Zoetis Merck Merial Elanco Bayer
Boehringer I. Novartis Virbac CEVA Others
€21bn
Growth Strategy
Expand market share of existing
portfolio while delivering innovation
Strengthen and expand 2013 acquired
TEVA US AH business
Drive research & development at a 10%
sales ratio
Explore M&A opportunities for further
growth
122. • Bayer Investor Presentation • Meet Management • June 2014Page 120
New Innovative Product Examples –
Recent Launch Highlights
New benchmark for flea
and tick protection
Outstanding efficacy
based on combination of
active ingredients
Up to 8 months protection
due to innovative polymer
matrix technology
Pradofloxacin, the new
generation fluoroquinolone
Extended spectrum vs.
previous fluoroquinolones
Greater potential to limit
selection for resistance
Convenient formulations
for dogs and cats
1st combined endopara-
siticide against
roundworm and coccidia
in dogs
Easy and convenient
once daily oral treatment
Can be used at 2-weeks
old
123. • Bayer Investor Presentation • Meet Management • June 2014Page 121
Innovative Life-Cycle Management –
Example of Advantage Family
Highlights
2002 2013
202
487
Sales in € million
Successful franchise through:
Brand building – investments in
direct-to-consumer for brand
awareness
Channel diversification – meeting
consumers where they are
Life Cycle Management (LCM) –
ongoing with new claims
125. • Bayer Investor Presentation • Meet Management • June 2014Page 123
Medical Care – Diabetes Care
and Radiology
DC & R
126. • Bayer Investor Presentation • Meet Management • June 2014Page 124
Radiology &
Interventional
Diabetes
Care
Sales Split 2013
Medical Care €2,526m; -5% (0%)
40% 60%
Medical Care – Strong Legacies in Diabetes
Care and Radiology
In € million, ∆% yoy, () = Fx & portf. adjusted
Diabetes Care:
Comprises self testing blood
glucose monitoring devices
Radiology
Combines our Contrast
Media, Injector and
Informatics businesses
127. • Bayer Investor Presentation • Meet Management • June 2014Page 125
Diabetes Care –
Global Player in Blood Glucose Meters
Highlights
Sales in € million; ∆% Fx & portfolio adj.
1,000 993 1,002
1,047
1,007
2009 2010 2011 2012 2013
-1%
Global #3 in blood glucose meters
Stable business performance despite
difficult market conditions
Market characterized by growth in
prevalence, but pricing pressure
Latest innovation products include
CONTOUR® Next and Next Link
MULTIPULSE technology ensures high
accuracy blood glucose measurements
Wireless transmission of results to Medtronic
insulin devices
128. • Bayer Investor Presentation • Meet Management • June 2014Page 126
1,363
1,474 1,498
1,606
1,519
2009 2010 2011 2012 2013
Sales in € million; ∆% Fx & portfolio adj.
0%
Radiology – Leading Positions in Contrast
Media and Application Devices
Integrated subsidiary Medrad Inc. and
our contrast media business
The business comprises:
Contrast media: CT and MRI
Contrast media injectors: Medrad
brand
Informatics
Services
Synergies through focus on similar
centers / physicians
Highlights
129. Investor Handout – Meet Management
Bayer CropScience
June 2014 – New York
130. 18%
25%
11%
11%
7%
28%
Sales 2013: €8,819m
Insecticides€1,622m
Market position:
Fungicides€2,195m
3Market position:
SeedGrowth€921m
1-2Market position:
Herbicides €2,456m
4Market position:
Env. Science €651m
1Market position:
Seeds €974m
7Market position:
Page 128
CropScience –
A Leader in Chemical Crop Protection
• Bayer Investor Presentation • Meet Management • June 2014
1
Market positions based on company reportings and Cropnosis estimates
Page 128
135. Emerging Economies
25%
CropScience Sales in FY 2013
CropScience €8,819m; +5% (+10%)
Latin
America
Eastern
Europe
Africa &
Middle East
Emerging
Asia³
~900
+11% ~2,200
+27%
~600
+9%
~300
+4%
Page 133
17%
USA
+3%
25%
45%
13%
Emerging
Economies¹
+18%
Western
Europe +3%
Others²
+6%
FY 2013 –
Strong Growth in Emerging Economies
Sales in € million, ∆% yoy Fx adjusted
• Bayer Investor Presentation • Meet Management • June 2014
1: Emerging economies include: Latin America, Asia w/o Japan, Australia, New Zealand, Africa and Middle East incl. Turkey, Eastern Europe
2: Others = Japan, Australia, New Zealand, Canada; 3: Emerging Asia = Asia w/o Japan, Australia, New Zealand
136. • Bayer Investor Presentation • Meet Management • June 2014
Successful Start to The Year
Page 134
137. Sales Earnings
Q1 2014 – CropScience:
Early Start to the Season in Europe
Page 135
Crop Protection
+6% (+12%)
Environmental Science
+1% (+8%)
Seeds
+3% (+12%)
In € million, ∆% yoy, () = Fx & portf. adjusted
CropScience €2,900m; +5% (+12%)
Price
+2%
Volume
+10%
Fx
-7%
Portfolio
0%
2,231
Q1‘13 Q1‘14 Q1‘13 Q1‘14
1,081 1,098 +2%
969 988 +2%
Adj.
EBITDA*
Adj.
EBIT*
166
503
• Bayer Investor Presentation • Meet Management • June 2014
*before special items
138. Herbicides
Fungicides
Seeds
503
+12%
Insecticides
Sales in € million; ∆% y-o-y Fx & portfolio adj.
Q1 2013 Nominal growth Q1 2014
• Bayer Investor Presentation • Meet Management • June 2014
Env.
Science
Q1 2014 – Growth Driven by All Segments
Page 136
965
+8%
662
+17%
352
+13%
252
+ 19%
166
+ 8%
Seed
Growth
Strong demand for cereal herbicides
in Europe
Early start to the season in Europe;
Growth in LatAm mainly driven by Fox
High demand in the US, especially for
Poncho family in corn and soybean
Marked sales increase in Europe and
LatAm; excellent performance of Belt
Growth in the Americas, mainly driven
by cotton and vegetable seeds
Positive performance for both
professional and consumer business
139. • Bayer Investor Presentation • Meet Management • June 2014
Customer-Centric Strategy
Pays Off
Page 137
140. Customer-Centric Strategy Pays Off
Strengthen
Customer Centricity
Lead the Way
in Innovation
Enhance
Crop Protection &
Environmental Science
Striving for first- and
best-in-class
solutions
Exploiting expertise
in seeds, breeding,
and chemical and
biological crop
protection
Driving commercial
excellence in
marketing and sales
Connecting partners
in the value chain
through integrated
Go-to-Market
practices
Improving portfolio
through focused
and integrated
crop solutions
Increasing
flexibility and
efficiency
Expand
Seeds Business
Further strengthening
position in
vegetables, rice,
oilseed rape
and cotton
Extending portfolio
by building up
business in soybean
and wheat
• Bayer Investor Presentation • Meet Management • June 2014Page 138
141. Q1 2014 - Significant Contribution from
New Crop Protection Products
1.1
1.5
1.8
2.6
2012 2013 2014e 2016e
+33%
Sales from new Crop Protection products
launched since 2006 in €bn
∆% y-o-y, () Fx adj.
• Bayer Investor Presentation • Meet Management • June 2014
(+16%) - Superior ‘all-in-one’
cereal fungicide with yield-boosting
effect
herbicide (+14%) -
Excellent weed control in corn and
cereals, also in case of glyphosate
resistance
(+75%) - Broad-spectrum
insecticide with fast, long-lasting
action
(+112%) - New fungicide now
available in several key markets
Q1 2014 Highlights
Q1
0.6
Page 139
142. Xpro – New Cereal Fungicide
with Yield-Boosting Effect
Pyrazole fungicide from a new generation of SDHI* for foliar use in cereals
Combined formulation of Bixafen and Prothioconazole leading to superior
"all-in-one" cereal fungicide Xpro
Excellent control of key cereal diseases including strobilurin-resistant Septoria
Boosting yield through long-lasting disease control and positive impact on
plant physiology
Global peak sales potential of more than €300m
* SDHI: Succinate dehydrogenase inhibitor
• Bayer Investor Presentation • Meet Management • June 2014Page 140
143. Luna – Outstanding Fungicide for Managing
Problematic Crop Diseases
New SDHI* fungicide for use in foliar application and seed treatment on more
than 70 horticultural and industrial crops
Control for a broad range of problematic diseases including Alternaria blight,
scab, powdery mildew and white mold
Benefits for the food chain through better storability and longer shelf-life of
harvested produce
Available since 2012 planting season in several key markets
Global peak sales potential of more than €250m
* SDHI: Succinate dehydrogenase inhibitor
• Bayer Investor Presentation • Meet Management • June 2014Page 141
144. Adengo Family – Highly Effective Weed
Control in Corn
Thiencarbazone-methyl is a new sulfonyl-amino-
carbonyl-triazolinone (SACT) herbicide
Additional crop selectivity in combination with
HPPD inhibitor Isoxaflutole and safener Cyprosulfamide
Grower benefits:
Controls annual grasses and broad leaved weeds in
corn including those that are resistant to glyphosate
Offering flexibility in application timing
Strong enough to achieve one-pass weed control
Rapid burndown, long-lasting residual control
• Bayer Investor Presentation • Meet Management • June 2014
Peak sales potential of more than €350m
Page 142
145. Belt Insecticide - Preserve Yield Potential
Flubendiamide is a phthalic acid diamide
Acts as ryanodine receptor modulator, larvae loses
muscle control
Grower benefits:
Controls lepidoptera pests in a wide range of crops,
including soybeans, corn and cotton
Fast action, larvae stops feeding immediately
Rainfast with excellent residual activity
Provides minimal risk to beneficial insects
Excellent resistance management tool
• Bayer Investor Presentation • Meet Management • June 2014
Control
+ BELT®
Heliothis
Peak sales potential of more than €300m
Page 143
146. Sustainable Alternatives to Fight Glyphosate
Weed Resistance
• Bayer Investor Presentation • Meet Management • June 2014
Weed resistance to glyphosate increasingly impacting crop production;
almost 50% of U.S. growers are affected
Our LibertyLink is currently the only non-selective herbicide solution to
glyphosate resistant weeds
Significant expansion of production capacity for Liberty planned
We are committed to develop new and more sustainable weed
management solutions
Highly effective pre-emergent and selective herbicide portfolio launched
100
200
300
400
2010 2011 2012 2013
Liberty/Basta Sales in €m
Page 144
147. Future Market Potential of Biologicals
Expected to Increase Significantly
Biologicals are products derived from naturally-occurring living organisms or
materials from plants or microorganisms
Increasing demand from consumers for safe and sustainably produced food,
especially in fruits & vegetables area
Global retailers have more stringent residue reduction targets
Currently lower regulatory hurdles and faster registration process for
biologicals compared to chemicals
Grower benefits from short pre-harvest and re-entry intervals and thus high
flexibility on application timing
When used in combination or rotation with chemicals, biologicals provide new
tools in resistance management
• Bayer Investor Presentation • Meet Management • June 2014
Market potential expected to triple from $1.2bn in 2010 to $4bn in 2020
Page 145
148. Further Growth Opportunities in Biologicals
with Bolt-On Acquisitions
Successful market entry with nematode seed treatment Poncho/Votivo in 2011
(Sales 2013: €150m)
AgraQuest acquired in Q3 2012 for €375m including milestone payments.
Global provider of innovative biological pest management solutions based
on natural microorganisms
Prophyta acquired in Q1 2013, a provider of well-established products,
e.g. nematicide BioAct
Biagro acquisition* adds nitrogen inoculants and plant health promoters
We aim to become the world leader in integrated crop solutions
• Bayer Investor Presentation • Meet Management • June 2014
* Clearance by Antitrust Authority in Argentina outstanding
Page 146
149. Acquisition of Biagro to Strengthen our
Soybean Business in Latin America
Argentinean company Biagro acquired in Q1 2014*
Biagro portfolio includes seed-applied biofertility
inoculants and plant growth-promoting microorganisms
Acquisition is a further milestone to become a leader in
biological seed treatments
Provides soybean growers in Latin America with
innovative offerings to substantially improve productivity
Nitrogen essential for plant growth and soybean seed
production
Biagro inoculants are a very effective and cost-efficient
method of supplying nitrogen to soybeans and other
legume crops
• Bayer Investor Presentation • Meet Management • June 2014
* Clearance by Antitrust Authority in Argentina outstanding
Inoculants containing
high-quality Rhizobium
bacteria strains enable
plant roots to fix nitrogen
from the atmosphere,
resulting in enhanced
plant growth, more
vigorous root structure
and greener plant foliage
Page 147
150. Customer Centricity Along the Entire
Value Chain
• Bayer Investor Presentation • Meet Management • June 2014
Bayer CropScience
Our offers Growers
Distributors/
seedcompanies
Retailers
Advisors
Providing Seed-to-Shelf Solutions
Traders
Foodprocessors
Foodretailers
Consumers
Around 240 food chain partnerships covering most of the
main fruit & vegetable crops and rice
Premium seeds and effective crop protection products to maximize yield
Consistent and high harvest quality for efficient food processing
Meeting highest food safety standards
Better product quality for the consumer
Page 148
151. Serving Grower Needs Beyond
Crop Protection and Seeds
• Bayer Investor Presentation • Meet Management • June 2014
Services Examples
Providing agronomic support
Crop advice
Expert trainings
On-farm trials
Field days
Optimizing yield and quality by
offering diagnostic and prediction
tools
Weather forecast
Pest prediction
Disease diagnosis
Resistance risk
calculator
Assessment of quality
indicators
Helping to optimize application
process and seeding
Application
collaborating with
machinery providers
Seed treatment
equipment checks
Creating transparency by offering
tracking / documentation support
Field documentation
RoI calculation
Certification support
Improving farm management by
financing and insurances
Ag input financing
Barter business
Crop price insurance
Page 149
152. • Bayer Investor Presentation • Meet Management • June 2014
Translating R&D Effectively
into Sales
From to
€
Page 150
153. Pipeline Peak Sales Potential €4bn
from Products Launched 2011 - 2016*
• Bayer Investor Presentation • Meet Management • June 2014
Crop Protection
Life Cycle Management
Seeds
Cotton
Canola
Wheat
Soybean
Rice
2013
~110 launches in vegetables &
broad acre crops
Roundup Ready
Hybrid
Canola
Fungicide
Serenade Optimum
Bayer Oilseed
Mustard
Hybrids
Seed Varieties
2014
Canola Yield
Increase
Numerous launches in
vegetables & broad acre crops
Verango / Velum
Insecticide
Insect Resistant
Hybrid Rice
TwinLink +
GlyTol Cotton
Seed Varieties
20162015
*estimated and subject to regulatory approval
2 joint project with MS Technologies
Constant Life Cycle Management through new formulations and mixtures that also includes Biologicals
Disease Resistant
+ Salinity Tolerant
Hybrid Rice
Insect + Disease
Resistant
Hybrid Rice
Improved Canola
Oil Profile
Dual Herbicide Tol.
+ Novel Insect
Resistant Cotton
Insecticide
Biologicals
Seed Varieties
Numerous launches in
vegetables & broad acre crops
GlyTol + HPPD
Tolerant
Soybeans2
Biologicals
Fungicide
Bayer
Wheat Seed
LibertyLink +
Roudup Ready
Hybrid Canola
Council
Herbicide
Disease Resistant +
Submergence Tol.
Hybrid Rice
Seed Varieties
Numerous launches in
vegetables & broad acre crops
Sivanto
Insecticide
Page 151
154. Sivanto – Innovative and User-friendly
Insecticide Against Sucking Pests
Active ingredient: flupyradifurone (novel insecticide class butenolides)
Control of sucking pests such as aphids, hoppers and whiteflies
Intended for use in fruits, vegetables, and broad acre crops
Favorable safety profile
Launch planned 2015*
• Bayer Investor Presentation • Meet Management • June 2014
* first registrations for foliar application; SeedGrowth use
planned to follow subsequentlyPage 152
155. Biological Crop Protection for Mite Control
Mites can significantly reduce
yields and quality
Leading to rejection of produce
along the value chain and
lower sales
Microbial acaricide with new
mode of action
Season-long effectiveness:
curative, eradicant, protective
Registration expected in the U.S.
in 2016*
• Bayer Investor Presentation • Meet Management • June 2014
* subject to regulatory approval
Two-spotted spider mite under scanning electron microscope (SEM)
Page 153
156. Build up a Global Wheat Seed Business
Largest broad-acre crop worldwide
Market value still small, but major potential seen with productivity improvement
Hybrids provide opportunity for both yield increase and improved yield stability
• Bayer Investor Presentation • Meet Management • June 2014
The Market* Our Efforts Our Goals
• 7 breeding centers
• Numerous collaborations
• Significant R&D investments
The Market
• 226m ha of wheat acres,
majority is farm-saved seed
• Current market of €0.2bn
(royalties only)
• Slow productivity increase
• Yield increase
• Nitrogen use efficiency
• Water use efficiency
• Heat tolerance
Market Entry
• Launch of first variety
planned in 2015
• Suitable for western and
central regions of the Ukraine
• Open pollinated variety
* Source: FAO, Context Networks 2012 (seed co level)
Corn: 60.7 EUR/ha Wheat: 0.9 EUR/ha
The Market
Page 154
157. Acquisitions in Latin America Broaden
our Portfolio in Soybean Seed
Building up proprietary seed
business with high quality germ-
plasm pool
Establishing best-in-class
breeding platform
Leveraging the potential of our trait
platform through out-licensing
Launch of Bayer soybean brand
Credenz planned late 2014
Integrated business model
combining seeds & crop protection
• Bayer Investor Presentation • Meet Management • June 2014
* subject to clearance by Antitrust Authority in Argentina
2013 FN Semillas*
soybean seed
company
Buenos Aires, Argentina
2011 Soytech
soybean seed
company
Goiânia, Goiás
2013 Wehrtec
soybean seed
company
Cristalina, Goiás
2013 Agropastoril
soybean germplasm
bank
Cascaval, Paraná
2010 CVR
plant breeding
Rio Verde, Goiás
Page 155
158. Strategic Progress Achieved
Enhance
Crop Protection
& Env. Science
Strengthen
Customer
Centricity
Lead the Way
in Innovation
Expand Seeds
Business
● €1.5bn sales in 2013 with products launched since 2006
● Biologicals strengthened further with Prophyta and Biagro*
● Expansion of supply capacities for key active ingredients
● Support to increase productivity of small-scale farmers
● Improved channel management practices
● Broadened food chain partnership business model
● Pipeline Peak Sales Potential** €4bn
● Increased investment in Seeds R&D
● Innovating at the interface between chemistry and biology
● Strengthened presence in Latin American soybean market
● Further investments done in wheat and vegetables
● Development of innovative traits
• Bayer Investor Presentation • Meet Management • June 2014
* Clearance by Antitrust Authority in Argentina outstanding
** from products launched between 2011-2016Page 156
159. • Bayer Investor Presentation • Meet Management • June 2014
2013 Sales CAGR 2016e
Further Growth at Benchmark
Profitability
Page 157
160. Global Trends in Agriculture
• Bayer Investor Presentation • Meet Management • June 2014
GLOBAL FOOD
PRODUCTION
CLIMATE CHANGE
-322 kg rice per hectare
Yields under pressure
+1°C
FARMLAND PER CAPITA (ha)
1950 : 0.52
2010 : 0.20
2050 : 0.15
INSUFFICIENT STORAGE
Up to 40% of fruit
and vegetables
lost in India
Equivalent to the annual
consumption in UK
CHANGING CONSUMPTION
PATTERNS
Increasing demand for protein
Need for a sustainable
productivity increase
By 2050
+70%
HUNGER
1 in 8 goes hungry today
POPULATION GROWTH
7 billion people
on the planet today
9.6 billion people in 2050
Page 158
162. Seed and Crop Protection Market Expected
to Grow 5% in 2014
• Bayer Investor Presentation • Meet Management • June 2014
In many growing regions farmer income level is healthy after 3 good years
Commodity prices still above critical threshold for farmers, triggering
investment in high-value seeds and crop protection
Steady expansion of soybean farming in Latin America
Expansion of agricultural production in Asia/Pacific continues
DESPITE
Prices for agricultural commodities expected to be below 2013 levels
Global stocks-to-use ratios for key crop commodities on upward trend
Page 160
163. Promising 2014 Outlook
We expect to grow faster than the market
We plan to raise sales by a mid- to high-single-digit percentage on a
currency- and portfolio-adjusted basis
We anticipate negative currency effects of about 3%
We plan to increase EBITDA before special items by a low single-digit
percentage, allowing for negative currency effects of approx. €150m
• Bayer Investor Presentation • Meet Management • June 2014
Outlook depends on specific planning assumptions as detailed in the Annual Report
Assuming average FX rates of Q4‘13 (USD 1.36)Page 161
164. CropScience – Above Market Growth at
Benchmark Profitability
2013
Guidance
2014
Aspiration
2016
Sales Increase €8.8bn Mid- to high-single-digit %
(neg. FX effect approx. -3%)
6% CAGR
Adj. EBITDA Increase €2.2bn Low-single-digit %
(neg. FX effect approx. -€150m)
Adj. EBITDA Margin 25.5% - 24-25%
Assuming average FX rates of Q4‘13 (USD 1.36)
Sales ∆ % Fx & portf. adjusted, margin = EBITDA before special items to sales
• Bayer Investor Presentation • Meet Management • June 2014Page 162
165. Increasing demand for innovative and
sustainable agricultural solutions
Expansion of production capacity of
for herbicide glufosinate-ammonium
Broadening seeds infrastructure for
soybean and wheat
Expanding and modernizing R&D
facilities
CAPEX expansion to
€2.4bn for 2013 - 2016
Stepping Up Investment Plans to Fuel
Future Growth
• Bayer Investor Presentation • Meet Management • June 2014
Capital Expenditures (PPE only, in €m)
303
453
620
2012 2013 2014e
Page 163
166. Investor Handout – Meet Management
Bayer MaterialScience
June 2014 – New York
167. MaterialScience –
Leading Positions in All Segments
• Bayer Investor Presentation • Meet Management • June 2014
* Aliphatic isocyanates
MaterialScience €11,238m
Polyurethanes
€6,054m
#1-2; approx. 19-24% market share
54% 6%
23%
17%
Sales in € million
Polycarbonates
€2,640m
#1; approx. 27% market share
Coatings, Adhesives, Specialties
€1,863m
#1; >40% market share*
Industrial Operations
€681m
Sales Split by Segment 2013
Page 165
168. MaterialScience –
Global Production Network
• Bayer Investor Presentation • Meet Management • June 2014Page 166
*Market share based on estimated sales following self-assessment
# Europe, Middle East & Africa
Headquarters
Major Production Sites
Downstream Businesses
Position*
Americas
# 1 # 2 # 1
PUR PCS CAS
Position*
EMEA#
# 1 # 1 # 1
PUR PCS CAS
Position*
Asia/Pacific
# 2-3 # 1-2 # 1
PUR PCS CAS
169. • Bayer Investor Presentation • Meet Management • June 2014Page 167
Automotive
Other industries*
Construction Furniture / Wood Electro / Electronics
19% 18% 15%21%
MaterialScience –
Sales By Key Customer Industries
Bayer MaterialScience sales by industry in 2013
= 73% +
Chemicals
*Sports/leisure, cosmetics, health
10% 17%
170. MaterialScience as an Integrated Solution
Provider
• Bayer Investor Presentation • Meet Management • June 2014Page 168
Megatrends offer business opportunities worldwide, with the emerging
economies at the forefront
Ongoing
urbanization
New and
improved
transportation
systems
Need for
better
energy
efficiency
Higher
living
standards
Proportion of city
dwellers expected to
increase from 50%
in 2010 to 70% in
2050*
Lightweight cars
New energy vehicle
development
High-speed rail trans-
portation networks
EcoConstruction with
high thermal insulation
standards
Cold-chain efficiency
Over 40m people
enter the middle class
every year
Improved housing
standards
Source: Steria, The Future Report 2012